search button

Association between serum tumor markers and metabolic tumor volume or total lesion glycolysis in patients with recurrent small cell lung cancer

  • Authors:
    • Pengyue Shi
    • Xue Meng
    • Mengmeng Ni
    • Xindong Sun
    • Ligang Xing
    • Jinming Yu

  • View Affiliations

  • Published online on: September 3, 2015     https://doi.org/10.3892/ol.2015.3673
  • Pages: 3123-3128
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to investigate the association between serum tumor markers and the metabolic tumor volume (MTV) or total lesion glycolysis (TLG), as determined by fluorine‑18 fluorodeoxyglucose (18F‑FDG) positron emission tomography‑computed tomography (PET/CT) in patients with recurrent small cell lung cancer (SCLC). Data from 21 patients with recurrent SCLC were collected. The levels of neuron‑specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19 fragment 21‑1 were measured at the time of the 18F‑FDG PET/CT examination. The MTV and TLG of all lesions were calculated. Pearson correlation analyses were used to estimate the correlations between NSE level and PET findings. Pearson correlation analyses showed that NSE was the only tumor marker to have a strong correlation with MTV or TLG (r=0.787, P<0.001; r=0.866, P<0.001, respectively). In patients with a normal NSE level, no correlation was found between NSE and MTV or TLG (r=0.018, P=0.958; r=‑0.003, P=0.92, respectively), but a significant correlation was found in patients with an abnormal NSE level (r=0.789, P<0.01; r=0.872, P=0.01, respectively). Therefore, TLG and MTV may serve as sensitive markers of tumor burden in patients with recurrent SCLC, with TLG showing greater sensitivity. In patients with an abnormal NSE level, a higher NSE level indicates greater MTV and TLG.
View Figures
View References

Related Articles

Journal Cover

November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.9
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Shi P, Meng X, Ni M, Sun X, Xing L and Yu J: Association between serum tumor markers and metabolic tumor volume or total lesion glycolysis in patients with recurrent small cell lung cancer. Oncol Lett 10: 3123-3128, 2015
APA
Shi, P., Meng, X., Ni, M., Sun, X., Xing, L., & Yu, J. (2015). Association between serum tumor markers and metabolic tumor volume or total lesion glycolysis in patients with recurrent small cell lung cancer. Oncology Letters, 10, 3123-3128. https://doi.org/10.3892/ol.2015.3673
MLA
Shi, P., Meng, X., Ni, M., Sun, X., Xing, L., Yu, J."Association between serum tumor markers and metabolic tumor volume or total lesion glycolysis in patients with recurrent small cell lung cancer". Oncology Letters 10.5 (2015): 3123-3128.
Chicago
Shi, P., Meng, X., Ni, M., Sun, X., Xing, L., Yu, J."Association between serum tumor markers and metabolic tumor volume or total lesion glycolysis in patients with recurrent small cell lung cancer". Oncology Letters 10, no. 5 (2015): 3123-3128. https://doi.org/10.3892/ol.2015.3673