Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma

  • Authors:
    • Eun‑Young Lee
    • Ji‑Yeon Kang
    • Kyoung-Won Kim
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Chungbuk 361‑711, Republic of Korea, Department of Oral and Maxillofacial Surgery, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong, Gyeonggi 445‑170, Republic of Korea
  • Pages: 3129-3136
    |
    Published online on: September 16, 2015
       https://doi.org/10.3892/ol.2015.3705
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumor development and progression are multistep processes that involve local tumor growth and invasion, followed by metastasis. The aggressiveness of the tumor is the major determinant of the mortality of oral cancer patients. The present study investigates whether the expression levels of cyclooxygenase‑2 (COX‑2), nuclear factor‑κB (NF‑κB), peroxiredoxin 1 (PRDX1) and PRDX6 are associated with the development, proliferation, differentiation and recurrence of oral squamous cell carcinoma (OSCC). The mRNA expression levels of COX‑2, NF‑κB, PRDX1 and PRDX6 were examined in 50 OSCC specimens and 19 normal oral mucosae by quantitative polymerase chain reaction (qPCR). qPCR analysis showed that the mRNA levels of COX‑2 in OSCC were significantly higher than those in the normal oral mucosae (P=0.021). The expression levels of PRDX1 in high‑stage tumors (T3 and T4) were significantly elevated compared with those in low‑stage tumors (T1) (P=0.047). Additionally, the expression levels of NF‑κB in the high‑grade tumor were significantly elevated compared with those in the low‑grade tumors (P=0.030). Overall, it was indicated that the expression of COX‑2 is strongly associated with the development of OSCC. Moreover, the enhanced expression of PRDX1 and NF‑κB may function in the progression of OSCC, which serves as a useful marker for prognosis in patients with oral cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bianchi B, Ferri A, Ferrari S, et al: Reconstruction of lateral through and through oro-mandibular defects following oncological resections. Microsurgery. 30:517–525. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Thankappan K, Kuriakose MA, Chatni SS, Sharan R, Trivedi NP, Vijayaraghavan S, Sharma M and Iyer S: Lateral arm free flap for oral tongue reconstruction: An analysis of surgical details, morbidity, and functional and aesthetic outcome. Ann Plast Surg. 66:261–266. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Zeno HA, Sternberger SS, Tuminelli FJ, Billotte M and Kurtz KS: Combination lower lip prosthesis retained by an intraoral component. J Prosthodont. 22:397–401. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Kawase-Koga Y, Mori Y, Saijo H, Hoshi K and Takato T: Reconstruction of a complex midface defect from excision of a squamous cell carcinoma, according to regional aesthetic units. Oral Surg Oral Med Oral Pathol Oral Radiol. 117:e97–e101. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Chiesa F, Mauri S, Tradati N, Calabrese L, Giugliano G, Ansarin M, Andrle J, Zurrida S, Orecchia R and Scully C: Surfing prognostic factors in head and neck cancer at the millennium. Oral Oncol. 35:590–596. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Brinkman BM and Wong DT: Disease mechanism and biomarkers of oral squamous cell carcinoma. Curr Opin Oncol. 18:228–233. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Babu GS, Supriya AN, Kumar Raj NG and Swetha P: Tumor markers: An overview. J Orofac Sci. 3:87–95. 2012.

8 

Sudbø J and Reith A: The evolution of predictive oncology and molecular-based therapy for oral cancer prevention. Int J Cancer. 115:339–345. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Kujubu DA, Reddy ST, Fletcher BS and Herschman HR: Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells. J Biol Chem. 268:5425–5430. 1993.PubMed/NCBI

10 

Vane J: Towards a better aspirin. Nature. 367:215–216. 1994. View Article : Google Scholar : PubMed/NCBI

11 

Shibata M, Kodani I, Osaki M, Araki K, Adachi H, Ryoke K and Ito H: Cyclo-oxygenase-1 and-2 expression in human oral mucosa, dysplasias and squamous cell carcinomas and their pathological significance. Oral Oncol. 41:304–312. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Wood ZA, Schröder E, Robin Harris J and Poole LB: Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci. 28:32–40. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Yanagawa T, Ishikawa T, Ishii T, Tabuchi K, Iwasa S, Bannai S, Omura K, Suzuki H and Yoshida H: Peroxiredoxin I expression in human thyroid tumors. Cancer Lett. 145:127–132. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Kinnula VL, Lehtonen S, Sormunen R, Kaarteenahob WR, Kang SW, Rhee SG and Soini Y: Overexpression of peroxiredoxins III, IIIV and VI in malignant mesothelioma. J Pathol. 196:316–323. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Chang JW, Jeon HB, Lee JH, Yoo JS, Chun JS, Kim JH and Yoo YJ: Augmented expression of peroxiredoxin I in lung cancer. Biochem Biophys Res Commun. 289:507–512. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Noh DY, Ahn SJ, Lee RA, Kim SW, Park IA and Chae HZ: Overexpression of peroxiredoxin in human breast cancer. Anticancer Res. 21:2085–2090. 2001.PubMed/NCBI

17 

Prosperi MT, Ferbus D, Karczinski I and Goubin G: A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. J Biol Chem. 268:11050–11056. 1993.PubMed/NCBI

18 

Kang SW, Chae HZ, Seo MS, Kim K, Baines IC and Rhee SG: Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem. 273:6297–6302. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE and Walborg EF Jr: The role of oxidative stress in chemical carcinogenesis. Environ Health Perspect. 106:289–295. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Fujii J and Ikeda Y: Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Rep. 7:123–130. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Ishii T, Yamada M, Sato H, Matsue M, Taketani S, Nakayama K, Sugita Y and Bannai S: Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein. J Biol Chem. 268:18633–18636. 1993.PubMed/NCBI

22 

Liu M, Lawson G, Delos M, Jamart J, Ide C, Coche E, Weynand B, Desuter G, Hamoir M, Remacle M and Marbaix E: Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations. Head Neck. 25:280–288. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Matsumoto A, Okado A, Fujii T, Fujii J, Egashira M, Niikawa N and Taniguchi N: Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member. FEBS Lett. 443:246–250. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH and Van Etten RA: Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 424:561–565. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Greene FL, Page D, Morrow M, et al: Lip and oral cavity. AJCC Cancer Staging Manual (6th). (New York). Springer. 23–32. 2002.

26 

Wolff H, Saukkonen K, Anttila S, Karjalainen A, Vainio H and Ristimäki A: Expression of cyclooxygenase-2 in human lung carcinoma. Cancer Res. 58:4997–5001. 1998.PubMed/NCBI

27 

Shamma A, Yamamoto H, Doki Y, Okami J, Kondo M, Fujiwara Y, Yano M, Inoue M, Matsuura N, Shiozaki H and Monden M: Up-regulation of cyclooxygenase-2 in squamous carcinogenesis of the esophagus. Clin Cancer Res. 6:1229–1238. 2000.PubMed/NCBI

28 

Peng JP, Su CY, Chang HC, Chai CY and Hung WC: Overexpression of cyclo-oxygenase 2 in squamous cell carcinoma of the hypopharynx. Hum Pathol. 33:100–104. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Banerjee AG, Gopalakrishnan VK, Bhattacharya I and Vishwanatha JK: Deregulated cyclooxygenase-2 expression in oral premalignant tissues. Mol Cancer Ther. 1:1265–1271. 2002.PubMed/NCBI

30 

Yu HP, Xu SQ, Liu L, Shi LY, Cai XK, Lu WH, Lu B, Su YH and Li YY: Cyclo-oxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. Cancer lett. 198:193–201. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Tsujii M and DuBois RN: Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 83:493–501. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Zhi H, Wang L, Zhang J, Zhou C, Ding F, Luo A, Wu M, Zhan Q and Liu Z: Significance of COX-2 expression in human esophageal squamous cell carcinoma. Carcinogenesis. 27:1214–1221. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Kase S, Osaki M, Honjo S, Adachi H, Tsujitani S, Kaibara N and Ito H: Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in human esophageal squamous cell carcinomas. Virchows Arch. 442:129–135. 2003.PubMed/NCBI

34 

Quan C, Cha EJ, Lee HL, Han KH, Lee KM and Kim WJ: Enhanced expression of peroxiredoxin I and 6 correlates with development, recurrence and progression of human bladder cancer. J Urol. 175:1512–1516. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Lehtonen ST, Svensk AM, Soini Y, Pääkkö P, Hirvikoski P, Kang SW, Säily M and Kinnula VL: Peroxiredoxins, a novel protein family in lung cancer. Int J Cancer. 111:514–521. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Yanagawa T, Iwasa S, Ishii T, Tabuchi K, Yusa H, Onizawa K, Omura K, Harada H, Suzuki H and Yoshida H: Peroxiredoxin I expression in oral cancer: A potential new tumor marker. Cancer Lett. 156:27–35. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Wen ST and Van Etten RA: The pag gene product, a stress-induced protein with antioxidant properties, is an abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Genes Dev. 11:2456–2467. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Prospéri MT, Ferbus D, Rouillard D and Goubin G: The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress. FEBS Lett. 423:39–44. 1998. View Article : Google Scholar : PubMed/NCBI

39 

Yanagawa T, Omura K, Harada H, Ishii T, Uwayama J, Nakaso K, Iwasa S, Koyama Y, Onizawa K, Yusa H and Yoshida H: Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence. Int J Oral Maxillofac Surg. 34:915–920. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Richmond A: NF-kappa B chemokine gene transcription and tumour growth. Nat Rev Immunol. 2:664–674. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Loercher A, Lee TL, Ricker JL, Howard A, Geoghegen J, Chen Z, Sunwoo JB, Sitcheran R, Chuang EY, Mitchell JB, et al: Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res. 64:6511–6523. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Takada Y, Singh S and Aggarwal BB: Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 279:15096–15104. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Wolf JS, Chen Z, Dong G, Sunwoo JB, Bancroft CC, Capo DE, Yeh NT, Mukaida N and Van Waes C: IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival and proliferation in head and neck squamous cell carcinomas. Clin Cancer Res. 7:1812–1820. 2001.PubMed/NCBI

44 

Bancroft CC, Chen Z, Yeh J, Sunwoo JB, Yeh NT, Jackson S, Jackson C and Van Waes C: Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines. Int J Cancer. 99:538–548. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Nakayama H, Ikebe T, Beppu M and Shirasuna K: High expression levels of nuclear factor kappaB IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity. Cancer. 92:3037–3044. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lee EY , Kang JY and Kim K: Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma. Oncol Lett 10: 3129-3136, 2015.
APA
Lee, E. ., Kang, J., & Kim, K. (2015). Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma. Oncology Letters, 10, 3129-3136. https://doi.org/10.3892/ol.2015.3705
MLA
Lee, E. ., Kang, J., Kim, K."Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma". Oncology Letters 10.5 (2015): 3129-3136.
Chicago
Lee, E. ., Kang, J., Kim, K."Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma". Oncology Letters 10, no. 5 (2015): 3129-3136. https://doi.org/10.3892/ol.2015.3705
Copy and paste a formatted citation
x
Spandidos Publications style
Lee EY , Kang JY and Kim K: Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma. Oncol Lett 10: 3129-3136, 2015.
APA
Lee, E. ., Kang, J., & Kim, K. (2015). Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma. Oncology Letters, 10, 3129-3136. https://doi.org/10.3892/ol.2015.3705
MLA
Lee, E. ., Kang, J., Kim, K."Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma". Oncology Letters 10.5 (2015): 3129-3136.
Chicago
Lee, E. ., Kang, J., Kim, K."Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma". Oncology Letters 10, no. 5 (2015): 3129-3136. https://doi.org/10.3892/ol.2015.3705
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team