Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor: A case report

Inadomi,Kyoko; Kumagai,Hozumi; Takayoshi,Kotoe; Ariyama,Hiroshi; Kusaba,Hitoshi; Nishie,Akihiro; Yamamoto,Hidetaka; Takase,Ken; Tanaka,Mamoru; Sagara,Kosuke; Okumura,Yuta; Nio,Kenta; Nakano,Michitaka; Arita,Shuji; Oda,Yoshinao; Akashi,Koichi; Baba,Eishi

doi:10.3892/ol.2015.3708

November-2015 Volume 10 Issue 5

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November-2015 Volume 10 Issue 5

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Case Report

Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor: A case report

Authors:
- Kyoko Inadomi
- Hozumi Kumagai
- Kotoe Takayoshi
- Hiroshi Ariyama
- Hitoshi Kusaba
- Akihiro Nishie
- Hidetaka Yamamoto
- Ken Takase
- Mamoru Tanaka
- Kosuke Sagara
- Yuta Okumura
- Kenta Nio
- Michitaka Nakano
- Shuji Arita
- Yoshinao Oda
- Koichi Akashi
- Eishi Baba
View Affiliations / Copyright

Affiliations: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812‑8582, Japan, Department of Clinical Radiology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Department of Hematology, National Hospital Organization Kyushu Medical Center, Fukuoka 810‑0065, Japan, Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan
Pages: 2981-2985
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Published online on: September 16, 2015

https://doi.org/10.3892/ol.2015.3708
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Abstract

A 64-year-old male presented with increased abdominal fullness and fever. Radiological examination revealed moderate ascites, a tumor with a diameter of 12.5 cm in the mesenteric region, as well as multiple tumors in the thoracic and abdominal para‑aortic regions and in the left supraclavicular regions. Pathohistological findings of the biopsy specimen revealed atypical spindle cells accompanied by infiltration of lymphocytes. The plasmacytes were positive for CD68, murine double minute 2 and S‑100, while they were negative for α‑smooth muscle actin, cyclin‑dependent kinase 4 and anaplastic lymphoma kinase. Clinically, the patient presented systemic symptoms and laboratory results indicated an elevation in the inflammatory response, while the CT and MRI findings were consistent with an inflammatory myofibroblastic tumor (IMT). Based on the clinical and histological findings, the patient was diagnosed with IMT. In total, 4 cycles of combination chemotherapy with doxorubicin and ifosfamide were administered. Tumor size reduction by 50% was achieved subsequent to the 4th chemotherapy cycle. In conclusion, successful control of this rare metastatic IMT was achieved by systemic chemotherapy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor: A case report

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Abstract

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