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Review Open Access

p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review)

  • Authors:
    • Miguel Reis De Almeida
    • Mario Pérez‑Sayáns
    • José Manuel Suárez‑Peñaranda
    • José Manuel Somoza-Martín
    • Abel García‑García
  • View Affiliations / Copyright

    Affiliations: Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Health Research Institute of Santiago (IDIS), Santiago de Compostela, A Coruña, Spain, Department of Pathology and Forensic Sciences, University Hospital and School of Medicine of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
    Copyright: © Reis De Almeida et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2675-2682
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    Published online on: September 18, 2015
       https://doi.org/10.3892/ol.2015.3726
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Abstract

Regulation of the cell cycle is essential for carcinogenesis. The cell cycle is controlled by cyclin-dependent kinases (CDKs), which are upregulated by cyclins and downregulated by CDK inhibitors (CDKIs). Decreased p27Kip1 expression has been associated with survival rate, tumor size, histological differentiation and the presence of lymph node metastasis in patients with various types of cancer. The aim of the current study is to provide a literature review on the association between p27Kip1 expression and the clinical and pathological aspects of head and neck squamous cell carcinoma (HNSCC), and the expression of other CDKIs of the Cip/Kip family and cyclins. Throughout the literature, different methodologies were used to determine the immunohistochemical expression of p27Kip1; thus, results concerning p27Kip1 expression in HNSCC vary widely. However, it has now been confirmed that p27Kip1 is underexpressed in SCC cells. p27 may be a promising marker for determining the prognosis of HNSCC, despite the marked variability of the results obtained. An association between p27 expression and survival rate, time to recurrence and tumor stage has been observed. Based on the information currently available, it is premature to recommend the analysis of p27Kip1 expression in guiding HNSCC treatment planning. However, although relatively unstudied, the correlation between p27Kip1 expression and other tumor suppressor genes may turn out to be important in determining the prognosis of HNSCC. Further prospective studies utilizing standardized laboratory methodologies and statistics that facilitate meta-analyses are required to confirm this proposal.
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Copy and paste a formatted citation
Spandidos Publications style
Reis De Almeida M, Pérez‑Sayáns M, Suárez‑Peñaranda JM, Somoza-Martín JM and García‑García A: p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review). Oncol Lett 10: 2675-2682, 2015.
APA
Reis De Almeida, M., Pérez‑Sayáns, M., Suárez‑Peñaranda, J.M., Somoza-Martín, J.M., & García‑García, A. (2015). p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review). Oncology Letters, 10, 2675-2682. https://doi.org/10.3892/ol.2015.3726
MLA
Reis De Almeida, M., Pérez‑Sayáns, M., Suárez‑Peñaranda, J. M., Somoza-Martín, J. M., García‑García, A."p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review)". Oncology Letters 10.5 (2015): 2675-2682.
Chicago
Reis De Almeida, M., Pérez‑Sayáns, M., Suárez‑Peñaranda, J. M., Somoza-Martín, J. M., García‑García, A."p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review)". Oncology Letters 10, no. 5 (2015): 2675-2682. https://doi.org/10.3892/ol.2015.3726
Copy and paste a formatted citation
x
Spandidos Publications style
Reis De Almeida M, Pérez‑Sayáns M, Suárez‑Peñaranda JM, Somoza-Martín JM and García‑García A: p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review). Oncol Lett 10: 2675-2682, 2015.
APA
Reis De Almeida, M., Pérez‑Sayáns, M., Suárez‑Peñaranda, J.M., Somoza-Martín, J.M., & García‑García, A. (2015). p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review). Oncology Letters, 10, 2675-2682. https://doi.org/10.3892/ol.2015.3726
MLA
Reis De Almeida, M., Pérez‑Sayáns, M., Suárez‑Peñaranda, J. M., Somoza-Martín, J. M., García‑García, A."p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review)". Oncology Letters 10.5 (2015): 2675-2682.
Chicago
Reis De Almeida, M., Pérez‑Sayáns, M., Suárez‑Peñaranda, J. M., Somoza-Martín, J. M., García‑García, A."p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck (Review)". Oncology Letters 10, no. 5 (2015): 2675-2682. https://doi.org/10.3892/ol.2015.3726
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