Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

Liang,Yun; Ding,Luyin; Li,Xian; Wang,Weiqin; Zhang,Xiaohong

doi:10.3892/ol.2015.3766

December-2015 Volume 10 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

December-2015 Volume 10 Issue 6

Full Size Image

Case Report

Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

Authors:
- Yun Liang
- Luyin Ding
- Xian Li
- Weiqin Wang
- Xiaohong Zhang
View Affiliations / Copyright

Affiliations: Department of Hematology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
Pages: 3789-3792
|
Published online on: September 29, 2015

https://doi.org/10.3892/ol.2015.3766
Expand metrics +

Abstract

A preleukaemic phase, typified by transient pancytopenia, is a rare occurrence that usually affects children and adolescents. The present study reports the case of a 50-year-old woman with transient pancytopenia, which manifested as a fever, cough and severe anemia. Three weeks following treatment of pancytopenia with antibiotics, red blood cell and platelet transfusion, granulocyte colony‑stimulating factor and human γ globulin, the condition of the patient was improved. However, 3 weeks following discharge from hospital, the patient was diagnosed with acute lymphoblastic leukemia (ALL) with complex chromosomal abnormalities, including Philadelphia chromosome and P190 breakpoint cluster region‑ABL. Complete remission was achieved following one course of combination chemotherapy. In conclusion, adult ALL with pancytopenia as a preceding symptom is rare, difficult to diagnose early and easily misdiagnosed. In addition, the pathogenesis of ALL and the precipitating factors underlying this disease require further investigation.

View Figures

View References

1	Wegelius R: Bone marrow dysfunctions preceding acute leukemia in children: A clinical study. Leuk Res. 16:71–76. 1992. View Article : Google Scholar : PubMed/NCBI
2	Shi J, Shao ZH, Liu H, Bai J, Cao YR, He GS, Tu MF, Wang L, Hao YS, Yang TY and Yang CL: Transformation of myelodysplastic syndromes into acute myeloid leukemias. Chin Med J (Engl). 117:963–967. 2004.PubMed/NCBI
3	Hasle H, Heim S, Schroeder H, Schmiegelow K, Ostergaard E and Kerndrup G: Transient pancytopenia preceding acute lymphoblastic leukemia (pre-ALL). Leukemia. 9:605–608. 1995.PubMed/NCBI
4	Villarreal-Martínez L, Jaime-Pérez JC, Rodríguez-Martínez M, González-Llano O and Gómez-Almaguer D: Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: Report of two cases. Rev Bras Hematol Hemoter. 34:165–167. 2012. View Article : Google Scholar : PubMed/NCBI
5	Armata J, Grześkowiak-Melanowska J, Balwierz W, Najbar-Pabian A and Pawlik-Niesytto E: Prognosis in acute lymphoblastic leukemia (ALL) in children preceded by an aplastic phase. Leuk Lymphoma. 13:517–518. 1994. View Article : Google Scholar : PubMed/NCBI
6	Zhao H, Zhang L, Zhu X, Chen Y, Zou Y, Zhang L, Yang R and Han ZC: Transient pancytopenia preceding T lineage acute lymphoblastic leukemia. Acta Haematol. 112:167–169. 2004. View Article : Google Scholar : PubMed/NCBI
7	Li Q, Chen Z, You Y and Zou P: Transient pancytopenia preceding acute lymphoblastic leukemia with positive Philadelphia chromosome. Leuk Res. 32:1317–1320. 2008. View Article : Google Scholar : PubMed/NCBI
8	Kelly K and Murphy P: Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q. Leuk Res. 32:1936–1938. 2008. View Article : Google Scholar : PubMed/NCBI
9	Sohn SK, Suh JS, Lee J and Lee KB: Pancytopenic prodrome (pre-ALL) of acute lymphoblastic leukemia in adults: possible pathogenesis. Korean J Intern Med. 13:64–67. 1998. View Article : Google Scholar : PubMed/NCBI
10	Lee JH, Lee JH, Shin YR, Lee JS, Kim WK, Chi HS, Park CJ and Lee KH: Spontaneous remission of aplastic anemia: A retrospective analysis. Haematologica. 86:928–933. 2001.PubMed/NCBI
11	Bozkaya H, Yurdaydin C, Törüner M, Arat M, Bozdayi AM, Erekul S, Cinar K, Koç H and Uzunalimoğlu O: Remission of severe aplastic anemia associated with hepatitis B virus infection after viral clearance: Potential role of lamivudine. Dig Dis Sci. 47:1782–1785. 2002. View Article : Google Scholar : PubMed/NCBI
12	Majlis A, Smith TL, Talpaz M, O'Brien S, Rios MB and Kantarjian HM: Significance of cytogenetic clonal evolution in chronic myelogenous leukemia. J Clin Oncol. 14:196–203. 1996.PubMed/NCBI
13	Adele K: Current treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Haematologica. 95:8–12. 2010. View Article : Google Scholar : PubMed/NCBI
14	Matloub YH, Brunning RD, Arthur DC and Ramsay NK: Severe aplastic anemia preceding acute lymphoblastic leukemia. Cancer. 71:264–268. 1993. View Article : Google Scholar : PubMed/NCBI
15	Horsley SW, Colman S, McKinley M, Bateman CM, Jenney M, Chaplin T, Young BD, Greaves M and Kearney L: Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia. Genes Chromosomes Cancer. 47:333–40. 2008. View Article : Google Scholar : PubMed/NCBI
16	Heegaard ED, Madsen HO and Schmiegelow K: Transient pancytopenia preceding acute lymphoblastic leukaemia (pre-ALL) precipitated by parvovirus B19. Br J Haematol. 114:810–813. 2001. View Article : Google Scholar : PubMed/NCBI
17	Kishore J, Sen M and Kumar A and Kumar A: A pilot study on parvovirus B19 infection in paediatric haematological malignancies. Indian J Med Res. 133:407–413. 2011.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

This article is mentioned in:

Abstract

Figure 1

Related Articles