Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2015 Volume 10 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2015 Volume 10 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis

  • Authors:
    • Yuqing Sheng
    • Mingchang Zou
    • Yan Wang
    • Qiheng Li
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The First People's Hospital of Zhenjiang, Zhenjiang, Jiangsu 212002, P.R. China
  • Pages: 3737-3741
    |
    Published online on: October 12, 2015
       https://doi.org/10.3892/ol.2015.3795
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Natural products are a promising source for the development of novel cancer therapies, due to their potential effectiveness and low toxicity profiles. As a main component of Herba oxytropis, 2',4'‑dihydroxychalcone (TFC) is known to demonstrate anti‑tumor activity in vitro. In the present study, TFC was found to potently inhibit proliferation and induce apoptosis in PC‑3 human prostate cancer cells in a dose‑dependent manner. The results demonstrated that the induction of apoptosis is associated with cell cycle arrest at the G0/G1 phase and activation of caspase‑3/‑7. Additional mechanistic studies of two biomarkers, phosphatase and tensin homolog (PTEN) and cyclin‑dependent kinase inhibitor 1B (p27Kip1), in prostate cancer revealed that TFC treatment significantly upregulated the expression of PTEN and p27Kip1. The findings of the present study indicate that TFC‑induced apoptosis in PC‑3 cells via upregulation of PTEN and p27Kip1, which results in cell cycle arrest in G0/G1 phase, activation of caspase‑3/‑7 and induction of apoptosis. Therefore, TFC may be a potential compound for human prostate cancer therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Brawley OW, Barnes S and Parnes H: The future of prostate cancer prevention. Ann Ny Acad Sci. 952:145–152. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Crowell JA: The chemopreventive agent development research program in the Division of Cancer Prevention of the US National Cancer Institute: An overview. Eur J Cancer. 41:1889–1910. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Yue R, Li B, Shen Y, Zeng H, Li B, Yuan H, He Y, Shan L and Zhang W: 6-C-methyl flavonoids isolated from Pinus densata inhibit the proliferation and promote the apoptosis of the HL-60 human promyelocytic leukaemia cell line. Planta Med. 79:1024–1030. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Costa SS, Couceiro JN, Silva IC, Ddo Malvar C, Coutinho MA, Camargo LM, Muzitano MF and Vanderlinde FA: Flavonoids in the therapy and prophylaxis of flu: A patent review. Expert Opin Ther Pat. 22:1111–1121. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Wang Y, Chen Y, Wang J, Chen J, Aggarwal BB, Pang X and Liu M: Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor. Curr Mol Med. 12:153–162. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Priyadarsini Vidya R, Murugan Senthil R, Maitreyi S, Ramalingam K, Karunagaran D and Nagini S: The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol. 649:84–91. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Lou CH, Yang GM, Cai H, Zou M, Xu Z, Li Y, Zhao F, Li W, Tong L, Wang M and Cai B: 2′,4′-Dihydroxychalcone-induced apoptosis of human gastric cancer MGC-803 cells via down-regulation of survivin mRNA. Toxicol In Vitro. 24:1333–1337. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Chen JJ, Lee HH, Duh CY and Chen IS: Cytotoxic chalcones of flavonoids from the leaves of Muntingia calabura. Planta Med. 71:970–973. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Pouget C, Lauthier F, Simon A, Fagnere C, Basly JP, Delage C and Chulia AJ: Flavonoids: Structural requirements for antiproliferative activity on breast cancer cells. Bioorg Med Chem Lett. 11:3095–3097. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Lou C, Wang M, Yang G, Cai H, Li Y, Zhao F, Yang H, Tong L and Cai B: Preliminary studies on anti-tumor activity of 2′,4′-dihydroxychalcone isolated from Herba oxytropis in human gastric cancer MGC-803 cells. Toxicol In Vitro. 23:906–910. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Lu F and Xu XJ: Studies on flavonoids of Oxytropis falcata. Zhongguo Zhong Yao Zazhi. 32:318–320. 2007.(In Chinese).

14 

Porter AG and Jänicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6:99–104. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Macri E and Loda M: Role of p27 in prostate carcinogenesis. Cancer Metastasis Rev. 17:337–344. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Pourmand G, Ziaee AA, Abedi AR, Mehrsai A, Alavi HA, Ahmadi A and Saadati HR: Role of PTEN gene in progression of prostate cancer. Urol J. 4:95–100. 2007.PubMed/NCBI

17 

Liu Y, Hegde P, Zhang F, Hampton G and Jia S: Prostate cancer - a biomarker perspective. Front Endocrinol (Lausanne). 3:722012.PubMed/NCBI

18 

Wong RS: Apoptosis in cancer: From pathogenesis to treatment. J Exp Clin Canc Res. 30:872011. View Article : Google Scholar

19 

Saddoughi SA, Song P and Ogretmen B: Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem. 49:413–440. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Guo YP, Sklar GN, Borkowski A and Kyprianou N: Loss of the cyclin-dependent kinase inhibitor p27(Kip1) protein in human prostate cancer correlates with tumor grade. Clin Cancer Res. 3:2269–2274. 1997.PubMed/NCBI

21 

Yang RM, Naitoh J, Murphy M, Wang HJ, Phillipson J, de Kernion JB, Loda M and Reiter RE: Low p27 expression predicts poor disease-free survival in patients with prostate cancer. J Urol. 159:941–945. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Tsihlias J, Kapusta LR, DeBoer G, Morava-Protzner I, Zbieranowski I, Bhattacharya N, Catzavelos GC, Klotz LH and Slingerland JM: Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. Cancer Res. 58:542–548. 1998.PubMed/NCBI

23 

Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Millard SS, Gaudin PB, Fazzari M, Zhang ZF, Massague J and Scher HI: Distinct altered patterns of p27Kip1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. J Natl Cancer Inst. 90:1284–1291. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Kato JY, Matsuoka M, Polyak K, Massague J and Sherr CJ: Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Cell. 79:487–496. 1994. View Article : Google Scholar : PubMed/NCBI

25 

Le XF, Claret FX, Lammayot A, Tian L, Deshpande D, LaPushin R, Tari AM and Bast RC Jr: The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. J Biol Chem. 278:23441–23450. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Chu EC and Tarnawski AS: PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit. 10:RA235–RA241. 2004.PubMed/NCBI

27 

Furnari FB, Huang HJ and Cavenee WK: The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res. 58:5002–5008. 1998.PubMed/NCBI

28 

Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J and Dedhar S: Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA. 97:3207–3212. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Backman SA, Ghazarian D, So K, Sanchez O, Wagner KU, Hennighausen L, Suzuki A, Tsao MS, Chapman WB, Stambolic V and Mak TW: Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc Natl Acad Sci USA. 101:1725–1730. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Xie F, Su M, Qiu W, Zhang M, Guo Z, Su B, Liu J, Li X and Zhou L: Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN. Int J Mol Sci. 14:21215–21226. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Mamillapalli R, Gavrilova N, Mihaylova VT, Tsvetkov LM, Wu H, Zhang H and Sun H: PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(Kip1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol. 11:263–267. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sheng Y, Zou M, Wang Y and Li Q: 2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis. Oncol Lett 10: 3737-3741, 2015.
APA
Sheng, Y., Zou, M., Wang, Y., & Li, Q. (2015). 2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis. Oncology Letters, 10, 3737-3741. https://doi.org/10.3892/ol.2015.3795
MLA
Sheng, Y., Zou, M., Wang, Y., Li, Q."2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis". Oncology Letters 10.6 (2015): 3737-3741.
Chicago
Sheng, Y., Zou, M., Wang, Y., Li, Q."2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis". Oncology Letters 10, no. 6 (2015): 3737-3741. https://doi.org/10.3892/ol.2015.3795
Copy and paste a formatted citation
x
Spandidos Publications style
Sheng Y, Zou M, Wang Y and Li Q: 2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis. Oncol Lett 10: 3737-3741, 2015.
APA
Sheng, Y., Zou, M., Wang, Y., & Li, Q. (2015). 2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis. Oncology Letters, 10, 3737-3741. https://doi.org/10.3892/ol.2015.3795
MLA
Sheng, Y., Zou, M., Wang, Y., Li, Q."2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis". Oncology Letters 10.6 (2015): 3737-3741.
Chicago
Sheng, Y., Zou, M., Wang, Y., Li, Q."2',4'‑dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC‑3 human prostate cancer cell growth by induction of apoptosis". Oncology Letters 10, no. 6 (2015): 3737-3741. https://doi.org/10.3892/ol.2015.3795
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team