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Article

Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature

  • Authors:
    • Joanna Streb
    • Miroslawa Püsküllüoğlu
    • Izabela Glanowska
    • Sebastian Ochenduszko
    • Kamil Konopka
    • Radoslaw Łupkowski
    • Anna Michalowska‑Kaczmarczyk
    • Justyna Bochenek‑Cibor
    • Marcin Majka
    • Krzysztof Krzemieniecki
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, University Hospital, Jagiellonian University Medical College, Kraków 31‑008, Poland, Department of Radiation Therapy, St. Luke's Hospital, Tarnów 33‑100, Poland, Department of Transplantation, Polish‑American Institute of Pediatrics, Jagiellonian University Medical College, Kraków 31‑008, Poland
  • Pages: 3749-3755
    |
    Published online on: October 12, 2015
       https://doi.org/10.3892/ol.2015.3800
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Abstract

Currently, there are a few systemic treatment options for patients with metastatic colorectal cancer (mCRC). Targeted therapy used in this setting includes the use of monoclonal antibodies, such as cetuximab or panitumumab, directed against epidermal growth factor receptor. The aim of the present study was to estimate the frequency and severity of hypomagnesemia among patients with mCRC treated with cetuximab. The data from the Department of Clinical Oncology, University Hospital of Krakow (Krakow, Poland), concerning 52 patients treated between 2009 and 2013 were collected. Of these, 27 patients fulfilled the inclusion criteria to enter this retrospective study. The National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 were used to grade the level of hypomagnesemia. In total, 29.6% of all patients experienced hypomagnesemia during treatment, and the majority of cases were grade 1 (22.2%). There was no statistically significant correlation between magnesium (Mg) level and patient age, duration of treatment, localization of primary tumor or metastases, and the number of metastases. However, there was an upward trend in a logistic regression model showing that the risk of developing hypomagnesemia increases with age. Hypomagnesemia is a frequent problem among mCRC patients receiving cetuximab. It is essential to introduce guidelines regarding the monitoring of the Mg level and its supplementation in this group of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Streb J, Püsküllüoğlu M, Glanowska I, Ochenduszko S, Konopka K, Łupkowski R, Michalowska‑Kaczmarczyk A, Bochenek‑Cibor J, Majka M, Krzemieniecki K, Krzemieniecki K, et al: Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature. Oncol Lett 10: 3749-3755, 2015.
APA
Streb, J., Püsküllüoğlu, M., Glanowska, I., Ochenduszko, S., Konopka, K., Łupkowski, R. ... Krzemieniecki, K. (2015). Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature. Oncology Letters, 10, 3749-3755. https://doi.org/10.3892/ol.2015.3800
MLA
Streb, J., Püsküllüoğlu, M., Glanowska, I., Ochenduszko, S., Konopka, K., Łupkowski, R., Michalowska‑Kaczmarczyk, A., Bochenek‑Cibor, J., Majka, M., Krzemieniecki, K."Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature". Oncology Letters 10.6 (2015): 3749-3755.
Chicago
Streb, J., Püsküllüoğlu, M., Glanowska, I., Ochenduszko, S., Konopka, K., Łupkowski, R., Michalowska‑Kaczmarczyk, A., Bochenek‑Cibor, J., Majka, M., Krzemieniecki, K."Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature". Oncology Letters 10, no. 6 (2015): 3749-3755. https://doi.org/10.3892/ol.2015.3800
Copy and paste a formatted citation
x
Spandidos Publications style
Streb J, Püsküllüoğlu M, Glanowska I, Ochenduszko S, Konopka K, Łupkowski R, Michalowska‑Kaczmarczyk A, Bochenek‑Cibor J, Majka M, Krzemieniecki K, Krzemieniecki K, et al: Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature. Oncol Lett 10: 3749-3755, 2015.
APA
Streb, J., Püsküllüoğlu, M., Glanowska, I., Ochenduszko, S., Konopka, K., Łupkowski, R. ... Krzemieniecki, K. (2015). Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature. Oncology Letters, 10, 3749-3755. https://doi.org/10.3892/ol.2015.3800
MLA
Streb, J., Püsküllüoğlu, M., Glanowska, I., Ochenduszko, S., Konopka, K., Łupkowski, R., Michalowska‑Kaczmarczyk, A., Bochenek‑Cibor, J., Majka, M., Krzemieniecki, K."Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature". Oncology Letters 10.6 (2015): 3749-3755.
Chicago
Streb, J., Püsküllüoğlu, M., Glanowska, I., Ochenduszko, S., Konopka, K., Łupkowski, R., Michalowska‑Kaczmarczyk, A., Bochenek‑Cibor, J., Majka, M., Krzemieniecki, K."Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature". Oncology Letters 10, no. 6 (2015): 3749-3755. https://doi.org/10.3892/ol.2015.3800
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