Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report

Kurisu,Yoshitaka; Tsuji,Motomu; Yasuda,Emi; Fujiwara,Michiko; Moriwaki,Shinichi

doi:10.3892/ol.2015.3825

Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report

Authors:
- Yoshitaka Kurisu
- Motomu Tsuji
- Emi Yasuda
- Michiko Fujiwara
- Shinichi Moriwaki
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Affiliations: Department of Pathology, Osaka Medical College Hospital, Takatsuki, Osaka, Japan, Department of Dermatology, Osaka Medical College Hospital, Takatsuki, Osaka, Japan
Published online on: October 22, 2015 https://doi.org/10.3892/ol.2015.3825
Pages: 3823-3825

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Abstract

Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma, with the majority of cases occurring in the oral cavity and genital area. The present study describes a rare case of cutaneous VC of the neck manifesting as a semi‑pedunculated multinodular protrusion. Histological analysis revealed thickening of the epidermis and papillary growth. Although cellular atypia was generally mild, a large number of mitoses were observed, of which a small number were abnormal. Additionally, bulbous subepidermal invasion was observed. The lesion was differentiated from papillary squamous cell carcinoma, another rare subtype of squamous cell carcinoma, based on the presence of epidermal verrucous growth and the lack of remarkable nuclear atypia. Benign disorders, including seborrheic keratosis, fibroepithelial polyp, verruca vulgaris and pseudocarcinomatous hyperplasia, were also differentiated from the lesion. Immunohistochemical analysis of cytokeratin (CK)10 expression revealed attenuated staining of the lesion, therefore, anti-CK10 immunohistochemistry may be valuable in the diagnosis of VC.

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1	Rinker MH, Fenske NA, Scalf LA and Glass LF: Histologic variants of squamous cell carcinoma of the skin. Cancer Control. 8:355–363. 2001.
2	Schwartz RA: Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol. 32:1–21. 1995. View Article : Google Scholar : PubMed/NCBI
3	Assaf C, Steinhoff M, Petrov I, et al: Verrucous carcinoma of the axilla: Case report and review. J Cutan Pathol. 31:199–204. 2004. View Article : Google Scholar : PubMed/NCBI
4	Miller ME, Martin N, Julliard GF, Bhuta S and Ishiyama A: Temporal bone verrucous carcinoma: Outcomes and treatment controversy. Eur Arch Otorhinolaryngol. 267:1927–1931. 2010. View Article : Google Scholar : PubMed/NCBI
5	Indinnimeo M, Impagnatiello A, D'Ettorre G, et al: Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: Report of three cases. World J Surg Oncol. 11:2312013. View Article : Google Scholar : PubMed/NCBI
6	Cassarino DS, Derienzo DP and Barr RJ: Cutaneous squamous cell carcinoma: A comprehensive clinicopathologic classification. Part one. J Cutan Pathol. 33:191–206. 2006. View Article : Google Scholar : PubMed/NCBI
7	Shimizu A, Tamura A, Tanaka S, et al: Pedunculated verrucous carcinoma of the thigh. Eur J Dermatol. 15:393–395. 2005.PubMed/NCBI
8	Landman G, Taylor RM and Friedman KJ: Cutaneous papillary squamous cell carcinoma. A report of two cases. J Cutan Pathol. 17:105–110. 1990. View Article : Google Scholar : PubMed/NCBI
9	Azorín D, Rodríguez-Peralto JL, García-García E and Salamanca J: Cutaneous papillary squamous cell carcinoma. Report of three new cases and review of the literature. Virchows Arch. 442:298–301. 2003.PubMed/NCBI
10	Asato Y, Taira K, Yamamoto Y and Uezato H: Detection of human papillomavirus type 11 in a case of Buschke-Löwenstein tumor. Eur J Dermatol. 18:329–331. 2008.PubMed/NCBI
11	Hicheri J, Jaber K, Dhaoui MR, et al: Giant condyloma (Buschke-Löwenstein tumor). A case report. Acta Dermatovenerol Alp Pannonica Adriat. 15:181–183. 2006.PubMed/NCBI
12	El-Khoury J, Kibbi AG and Abbas O: Mucocutaneous pseudoepitheliomatous hyperplasia: A review. Am J Dermatopathol. 34:165–175. 2012. View Article : Google Scholar : PubMed/NCBI
13	Fillies T, Jogschies M, Kleinheinz J, et al: Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma. Oncol Rep. 18:639–643. 2007.PubMed/NCBI
14	Böer-Auer A, Jones M and Lyasnichaya OV: Cytokeratin 10-negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease. J Cutan Pathol. 39:225–233. 2012. View Article : Google Scholar : PubMed/NCBI
15	Okada Y and Moride M: Immunohistochemical study of differential expressions of cytokeratin-13, −14, −17 and p53 in epithelial dysplasia and carcinoma of the tongue. J Hard Tissue Biol. 19:123–130. 2010. View Article : Google Scholar
16	Yamashiro Y, Takei K, Umikawa M, et al: Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma. Biochem Biophys Res Commun. 399:365–372. 2010. View Article : Google Scholar : PubMed/NCBI
17	Dubina M and Goldenberg G: Viral-associated nonmelanoma skin cancers: A review. Am J Dermatopathol. 31:561–573. 2009. View Article : Google Scholar : PubMed/NCBI
18	Petter G and Haustein UF: Histologic subtyping and malignancy assessment of cutaneous squamous cell carcinoma. Dermatol Surg. 26:521–530. 2000. View Article : Google Scholar : PubMed/NCBI
19	Murao K, Kubo Y, Fukumoto D, et al: Verrucous carcinoma of the scalp associated with human papillomavirus type 33. Dermatol Surg. 31:1363–1365. 2005. View Article : Google Scholar : PubMed/NCBI