Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report

Kurisu,Yoshitaka; Tsuji,Motomu; Yasuda,Emi; Fujiwara,Michiko; Moriwaki,Shinichi

doi:10.3892/ol.2015.3825

December-2015 Volume 10 Issue 6

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December-2015 Volume 10 Issue 6

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Case Report

Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report

Authors:
- Yoshitaka Kurisu
- Motomu Tsuji
- Emi Yasuda
- Michiko Fujiwara
- Shinichi Moriwaki
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Affiliations: Department of Pathology, Osaka Medical College Hospital, Takatsuki, Osaka, Japan, Department of Dermatology, Osaka Medical College Hospital, Takatsuki, Osaka, Japan
Pages: 3823-3825
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Published online on: October 22, 2015

https://doi.org/10.3892/ol.2015.3825
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Abstract

Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma, with the majority of cases occurring in the oral cavity and genital area. The present study describes a rare case of cutaneous VC of the neck manifesting as a semi‑pedunculated multinodular protrusion. Histological analysis revealed thickening of the epidermis and papillary growth. Although cellular atypia was generally mild, a large number of mitoses were observed, of which a small number were abnormal. Additionally, bulbous subepidermal invasion was observed. The lesion was differentiated from papillary squamous cell carcinoma, another rare subtype of squamous cell carcinoma, based on the presence of epidermal verrucous growth and the lack of remarkable nuclear atypia. Benign disorders, including seborrheic keratosis, fibroepithelial polyp, verruca vulgaris and pseudocarcinomatous hyperplasia, were also differentiated from the lesion. Immunohistochemical analysis of cytokeratin (CK)10 expression revealed attenuated staining of the lesion, therefore, anti-CK10 immunohistochemistry may be valuable in the diagnosis of VC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report

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