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Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis

  • Authors:
    • Ming Zhao
    • Ke‑Jing Wang
    • Zhuo Tan
    • Chuan‑Ming Zheng
    • Zhong Liang
    • Jian‑Qiang Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 51-58
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    Published online on: October 26, 2015
       https://doi.org/10.3892/ol.2015.3829
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Abstract

The aim of the present study was to identify potential therapeutic targets for papillary thyroid carcinoma (PTC) and to investigate the possible mechanism underlying this disease. The gene expression profile, GSE53157, was downloaded from the Gene Expression Omnibus database. Only 10 chips, including 3 specimens of normal thyroid tissues and 7 specimens of well‑differentiated thyroid carcinomas, were analyzed in the present study. Differentially‑expressed genes (DEGs) between PTC patients and normal individuals were identified. Next, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of DEGs were performed. Modules in the protein‑protein interaction (PPI) network were identified. Significant target genes were selected from the microRNA (miRNA) regulatory network. Furthermore, the integrated network was constructed with the miRNA regulatory and PPI network modules, and key target genes were screened. A total of 668 DEGs were identified. Modules M1, M2 and M3 were identified from the PPI network. From the modules, DEGs of cyclin‑dependent kinase inhibitor 1A, S100 calcium binding protein A6 (S100A6), dual specificity phosphatase 5, keratin 19, met proto‑oncogene (MET) and lectin galactoside‑binding soluble 3 were included in the Malacards database. In the miRNA regulatory and integrated networks, genes of cyclin-dependent kinase inhibitor 1C (CDKN1C), peroxisome proliferator-activated receptor γ, aryl hydrocarbon receptor, basic helix-loop-helix family, member e40 and reticulon 1 were the key target genes. S100A6, MET and CDKN1C may exhibit key roles in the progression and development of PTC, and may be used as specific therapeutic targets in the treatment of PTC. However, further experiments are required to confirm these results.
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View References

1 

Zhang J, Yang Y, Liu Y, Fan Y, Liu Z, Wang X, Yuan Q, Yin Y, Yu J, Zhu M, et al: MicroRNA-21 regulates biological behaviors in papillary thyroid carcinoma by targeting programmed cell death 4. J Surg Res. 189:68–74. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Grant CS: Recurrence of papillary thyroid cancer after optimized surgery. Gland Surg. 4:52–62. 2015.PubMed/NCBI

4 

Srivastava A, Goldberger H, Dimtchev A, Ramalinga M, Chijioke J, Marian C, Oermann EK, Uhm S, Kim JS, Chen LN, et al: MicroRNA profiling in prostate cancer-the diagnostic potential of urinary miR-205 and miR-214. PloS One. 8:e769942013. View Article : Google Scholar : PubMed/NCBI

5 

Hodge LS, Elsawa SF, Grote DM, Price-Troska TL, Asmann YW, Fonseca R, Gertz MA, Witzig TE, Novak AJ and Ansell SM: MicroRNA expression in tumor cells from Waldenstrom's macroglobulinemia reflects both their normal and malignant cell counterparts. Blood Cancer J. 1:e242011. View Article : Google Scholar : PubMed/NCBI

6 

Adeniran AJ, Zhu Z, Gandhi M, Steward DL, Fidler JP, Giordano TJ, Biddinger PW and Nikiforov YE: Correlation between genetic alterations and microscopic features, clinical manifestations and prognostic characteristics of thyroid papillary carcinomas. Am J Surg Pathol. 30:216–222. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Espinosa AV, Porchia L and Ringel MD: Targeting BRAF in thyroid cancer. Br J Cancer. 96:16–20. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Pelizzo MR, Boschin IM, Barollo S, Pennelli G, Toniato A, Zambonin L, Vianello F, Piotto A, Ide EC, Pagetta C, et al: BRAF analysis by fine needle aspiration biopsy of thyroid nodules improves preoperative identification of papillary thyroid carcinoma and represents a prognostic factor. A mono-institutional experience. Clin Chem Lab Med. 49:325–329. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ye WC, Gao L, Huang J, Fang XM and Xie G: Suppressed Kruppellike factor 17 expression induces tumor proliferation, metastasis and a poor prognosis in papillary thyroid carcinoma. Mol Med Rep. 2014. View Article : Google Scholar

10 

Pennelli G, Fassan M, Mian C, Pizzi M, Balistreri M, Barollo S, Galuppini F, Guzzardo V, Pelizzo M and Rugge M: PDCD4 expression in thyroid neoplasia. Virchows Arch. 462:95–100. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Peng Y, Li C, Luo DC, Ding JW, Zhang W and Pan G: Expression profile and clinical significance of microRNAs in papillary thyroid carcinoma. Molecules. 19:11586–11599. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Pita JM, Banito A, Cavaco BM and Leite V: Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas. Br J Cancer. 101:1782–1791. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Gautier L, Cope L, Bolstad BM and Irizarry RA: affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Smyth GK: Limma: Linear models for microarray data. Bioinformatics and Computational Biology Solutions Using {R} and Bioconductor. Gentleman R, Carey VJ, Huber W, Irizarry RA and Dudoit S: (New York). Springer. 397–420. 2005. View Article : Google Scholar

15 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Statist Soc B. 57:289–300. 1995.

16 

Hulsegge I, Kommadath A and Smits MA: Globaltest and GOEAST: Two different approaches for gene ontology analysis. BMC Proc. 3(Suppl 4): S102009. View Article : Google Scholar : PubMed/NCBI

17 

Ogata H, Goto S, Sato K, Fujibuchi W, Bono H and Kanehisa M: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 27:29–34. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

19 

Rappaport N, Nativ N, Stelzer G, Twik M, Guan-Golan Y, Stein TI, Bahir I, Belinky F, Morrey CP, Safran M and Lancet D: Mala Cards: An integrated compendium for diseases and their annotation. Database (Oxford). 2013:bat0182013. View Article : Google Scholar : PubMed/NCBI

20 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, et al: The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39:D561–D568. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Morris JH, Apeltsin L, Newman AM, Baumbach J, Wittkop T, Su G, Bader GD and Ferrin TE: ClusterMaker: A multi-algorithm clustering plugin for Cytoscape. BMC Bioinformatics. 12:4362011. View Article : Google Scholar : PubMed/NCBI

24 

Enright AJ, Van Dongen S and Ouzounis CA: An efficient algorithm for large-scale detection of protein families. Nucleic Acids Res. 30:1575–1584. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Maere S, Heymans K and Kuiper M: BiNGO: A Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics. 21:3448–3449. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Wang J, Duncan D, Shi Z and Zhang B: WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): Update 2013. Nucleic Acids Res. 41:W77–W83. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Chen AY, Jemal A and Ward EM: Increasing incidence of differentiated thyroid cancer in the United States, 1988–2005. Cancer. 115:3801–3807. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Wang C and Crapo LM: The epidemiology of thyroid disease and implications for screening. Endocrinol Metab Clin North Am. 26:189–218. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Breen EC and Tang K: Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology and cytoskeletal organization in vitro. J Cell Biochem. 88:848–854. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Tsoporis JN, Izhar S and Parker TG: Expression of S100A6 in cardiac myocytes limits apoptosis induced by tumor necrosis factor-alpha. J Biol Chem. 283:30174–30183. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Cross SS, Hamdy FC, Deloulme JC and Rehman I: Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers. Histopathology. 46:256–269. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Ito Y, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, Matsuzuka F, Kakudo K, Kuma K and Miyauchi A: Expression of S100A2 and S100A6 in thyroid carcinomas. Histopathology. 46:569–575. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Li Z, Tang M, Ling B, Liu S, Zheng Y, Nie C, Yuan Z, Zhou L, Guo G, Tong A and Wei Y: Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma. J Mol Med (Berl). 92:291–303. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Komatsu K, Kobune-Fujiwara Y, Andoh A, Ishiguro S, Hunai H, Suzuki N, Kameyama M, Murata K, Miyoshi J, Akedo H, et al: Increased expression of S100A6 at the invading fronts of the primary lesion and liver metastasis in patients witholorectal adenocarcinoma. Br J Cancer. 83:7692000. View Article : Google Scholar : PubMed/NCBI

35 

Ito Y, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, Matsuzuka F, Kakudo K, Kuma K and Miyauchi A: Expression of S100A2 and S100A6 in thyroid carcinomas. Histopathology. 46:569–575. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Sofiadis A, Dinets A, Orre LM, Branca RM, Juhlin CC, Foukakis T, Wallin G, Höög A, Hulchiy M, Zedenius J, et al: Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+-binding protein S100A6 in papillary thyroid carcinoma. Thyroid. 20:1067–1076. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Pita JM, Figueiredo IF, Moura MM, Leite V and Cavaco BM: Cell cycle deregulation and TP53 and RAS mutations are major events in poorly differentiated and undifferentiated thyroid carcinomas. J Clin Endocrinol Metab. 99:E497–E507. 2014.PubMed/NCBI

38 

Quiros RM, Ding HG, Gattuso P, Prinz RA and Xu X: Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations. Cancer. 103:2261–2268. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK and Comoglio PM: Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene. 6:501–504. 1991.PubMed/NCBI

40 

Schmidt L, Junker K, Weirich G, Glenn G, Choyke P, Lubensky I, Zhuang Z, Jeffers M, Van de Woude G, Neumann H, et al: Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene. Cancer Rre. 58:1719–1722. 1998.

41 

Rong S, Donehower LA, Hansen MF, Strong L, Tainsky M, Jeffers M, Resau JH, Hudson E, Tsarfaty I and Van de Woude GF: Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients. Cancer Res. 55:1963–1970. 1995.PubMed/NCBI

42 

Fujita S and Sugano K: Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases. Jpn J Clin Oncol. 27:378–383. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Di Renzo M, Olivero M, Ferro S, Prat M, Bongarzone I, Pilotti S, Belfiore A, Costantino A, Vigneri R, Pierotti MA, et al: Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas. Oncogene. 7:2549–2553. 1992.PubMed/NCBI

44 

Di Renzo MF, Olivero M, Katsaros D, Crepaldi T, Gaglia P, Zola P, Sismondi P and Comoglio PM: Overexpression of the Met/HGF receptor in ovarian cancer. Int J Cancer. 58:658–662. 1994. View Article : Google Scholar : PubMed/NCBI

45 

Soejima H, Nakagawachi T, Zhao W, Higashimoto K, Urano T, Matsukura S, Kitajima Y, Takeuchi M, Nakayama M, Oshimura M, et al: Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer. Oncogene. 23:4380–4388. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Hoffmann MJ, Florl AR, Seifert HH and Schulz WA: Multiple mechanisms downregulate CDKN1C in human bladder cancer. Internat J Cancer. 114:406–413. 2005. View Article : Google Scholar

47 

Larson PS, Schlechter BL, King CL, Yang Q, Glass CN, Mack C, Pistey R, de Las Morenas A and Rosenberg CL: CDKN1C/p57kip2 is a candidate tumor suppressor gene in human breast cancer. BMC Cancer. 8:682008. View Article : Google Scholar : PubMed/NCBI

48 

Algar EM, Muscat A, Dagar V, Rickert C, Chow CW, Biegel JA, Ekert PG, Saffery R, Craig J, Johnstone RW and Ashley DM: Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. PLoS One. 4:e44822009. View Article : Google Scholar : PubMed/NCBI

49 

Tetzlaff MT, Liu A, Xu X, Master SR, Baldwin DA, Tobias JW, Livolsi VA and Baloch ZW: Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues. Endocr Pathol. 18:163–173. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L and Negrini M: MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene. 27:5651–5661. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao M, Wang KJ, Tan Z, Zheng CM, Liang Z and Zhao JQ: Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis. Oncol Lett 11: 51-58, 2016.
APA
Zhao, M., Wang, K., Tan, Z., Zheng, C., Liang, Z., & Zhao, J. (2016). Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis. Oncology Letters, 11, 51-58. https://doi.org/10.3892/ol.2015.3829
MLA
Zhao, M., Wang, K., Tan, Z., Zheng, C., Liang, Z., Zhao, J."Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis". Oncology Letters 11.1 (2016): 51-58.
Chicago
Zhao, M., Wang, K., Tan, Z., Zheng, C., Liang, Z., Zhao, J."Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis". Oncology Letters 11, no. 1 (2016): 51-58. https://doi.org/10.3892/ol.2015.3829
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao M, Wang KJ, Tan Z, Zheng CM, Liang Z and Zhao JQ: Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis. Oncol Lett 11: 51-58, 2016.
APA
Zhao, M., Wang, K., Tan, Z., Zheng, C., Liang, Z., & Zhao, J. (2016). Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis. Oncology Letters, 11, 51-58. https://doi.org/10.3892/ol.2015.3829
MLA
Zhao, M., Wang, K., Tan, Z., Zheng, C., Liang, Z., Zhao, J."Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis". Oncology Letters 11.1 (2016): 51-58.
Chicago
Zhao, M., Wang, K., Tan, Z., Zheng, C., Liang, Z., Zhao, J."Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis". Oncology Letters 11, no. 1 (2016): 51-58. https://doi.org/10.3892/ol.2015.3829
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