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Article

Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway

  • Authors:
    • Tingting Zhao
    • Qianting He
    • Zhonghua Liu
    • Xueqiang Ding
    • Xiaofeng Zhou
    • Anxun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 501180, P.R. China, Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
  • Pages: 340-344
    |
    Published online on: November 10, 2015
       https://doi.org/10.3892/ol.2015.3898
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Abstract

Our previous studies demonstrated that the downregulation of microtubule-associated tumor suppressor 1/angiotensin II type 2 receptor-interacting protein (MTUS1/ATIP) is associated with poor differentiation and prognosis in tongue squamous cell carcinoma (TSCC), and that ATIP1 exerts an antiproliferative effect on TSCC. The aim of the present study was to further investigate the anticancer effect of MTUS1/ATIP3a in TSCC. It was observed that UM1 cells (a TSCC cell line with high migration and invasion ability) exhibited lower expression of ATIP3a compared with UM2 cells (a TSCC cell line with lower migration and invasion ability). Restoration of ATIP3a expression in UM1 cells exerted antiproliferative effects and inhibited migration and invasion, whereas knockdown of ATIP3a promoted proliferation, migration and invasion in UM2 cells. Restoration of ATIP3a expression inhibited the phosphorylation of extracellular signal‑regulated kinase 1/2 (ERK1/2) and the expression of Snai2 and vimentin in UM1 cells, whereas knockdown of ATIP3a promoted the phosphorylation of ERK1/2 and the expression of Snai2 and vimentin in UM2 cells. Therefore, MTUS1/ATIP3a was found to suppress the proliferation, migration and invasion of TSCC cells via the ERK1/2-Snai2 pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao T, He Q, Liu Z, Ding X, Zhou X and Wang A: Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway. Oncol Lett 11: 340-344, 2016.
APA
Zhao, T., He, Q., Liu, Z., Ding, X., Zhou, X., & Wang, A. (2016). Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway. Oncology Letters, 11, 340-344. https://doi.org/10.3892/ol.2015.3898
MLA
Zhao, T., He, Q., Liu, Z., Ding, X., Zhou, X., Wang, A."Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway". Oncology Letters 11.1 (2016): 340-344.
Chicago
Zhao, T., He, Q., Liu, Z., Ding, X., Zhou, X., Wang, A."Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway". Oncology Letters 11, no. 1 (2016): 340-344. https://doi.org/10.3892/ol.2015.3898
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao T, He Q, Liu Z, Ding X, Zhou X and Wang A: Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway. Oncol Lett 11: 340-344, 2016.
APA
Zhao, T., He, Q., Liu, Z., Ding, X., Zhou, X., & Wang, A. (2016). Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway. Oncology Letters, 11, 340-344. https://doi.org/10.3892/ol.2015.3898
MLA
Zhao, T., He, Q., Liu, Z., Ding, X., Zhou, X., Wang, A."Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway". Oncology Letters 11.1 (2016): 340-344.
Chicago
Zhao, T., He, Q., Liu, Z., Ding, X., Zhou, X., Wang, A."Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway". Oncology Letters 11, no. 1 (2016): 340-344. https://doi.org/10.3892/ol.2015.3898
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