Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report

Kawasaki,Kenta; Hamamoto,Yasuo; Adachi,Masayuki; Kanai,Takanori; Takaishi,Hiromasa

doi:10.3892/ol.2015.3905

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Case Report Open Access

Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report

Authors:
- Kenta Kawasaki
- Yasuo Hamamoto
- Masayuki Adachi
- Takanori Kanai
- Hiromasa Takaishi
View Affiliations / Copyright

Affiliations: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku‑Ku, Tokyo 160‑8587, Japan, Keio Cancer Center, Keio University School of Medicine, Shinjuku‑Ku, Tokyo 160‑8587, Japan

Copyright: © Kawasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 231-233
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Published online on: November 10, 2015

https://doi.org/10.3892/ol.2015.3905
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Abstract

Tumoral cavity formation is a characteristic phenomenon reported in anti-angiogenic therapy in lung lesions. A 57-year-old male with multiple pulmonary metastases from colorectal cancer treated with an oral tyrosine kinase inhibitor, regorafenib, exhibited a characteristic cavity formation after the first two cycles. The decrease in the size of tumors was calculated as 38%, and there were associated decreases in the serum concentrations of the tumor markers carcinoembryonic antigen and CA19‑9. After eight cycles of treatment, the cavity gradually disappeared through filling‑in. This unique morphological response is not only reported in lung cancer but also in liver metastasis in colorectal cancer. However, the association between morphological changes including cavity formation and clinical benefit remains controversial. Pulmonary hemorrhage and pneumothorax are well‑known consequences of cavitation, as reported with the other anti‑angiogenic inhibitors. Early tumor cavitation in lung metastasis may demonstrate the predictive potential of regorafenib in colorectal cancer, although it is necessary to be mindful of toxicity.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report

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