Open Access

Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report

  • Authors:
    • Kenta Kawasaki
    • Yasuo Hamamoto
    • Masayuki Adachi
    • Takanori Kanai
    • Hiromasa Takaishi
  • View Affiliations

  • Published online on: November 10, 2015     https://doi.org/10.3892/ol.2015.3905
  • Pages: 231-233
  • Copyright: © Kawasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tumoral cavity formation is a characteristic phenomenon reported in anti-angiogenic therapy in lung lesions. A 57-year-old male with multiple pulmonary metastases from colorectal cancer treated with an oral tyrosine kinase inhibitor, regorafenib, exhibited a characteristic cavity formation after the first two cycles. The decrease in the size of tumors was calculated as 38%, and there were associated decreases in the serum concentrations of the tumor markers carcinoembryonic antigen and CA19‑9. After eight cycles of treatment, the cavity gradually disappeared through filling‑in. This unique morphological response is not only reported in lung cancer but also in liver metastasis in colorectal cancer. However, the association between morphological changes including cavity formation and clinical benefit remains controversial. Pulmonary hemorrhage and pneumothorax are well‑known consequences of cavitation, as reported with the other anti‑angiogenic inhibitors. Early tumor cavitation in lung metastasis may demonstrate the predictive potential of regorafenib in colorectal cancer, although it is necessary to be mindful of toxicity.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kawasaki K, Hamamoto Y, Adachi M, Kanai T and Takaishi H: Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report. Oncol Lett 11: 231-233, 2016
APA
Kawasaki, K., Hamamoto, Y., Adachi, M., Kanai, T., & Takaishi, H. (2016). Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report. Oncology Letters, 11, 231-233. https://doi.org/10.3892/ol.2015.3905
MLA
Kawasaki, K., Hamamoto, Y., Adachi, M., Kanai, T., Takaishi, H."Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report". Oncology Letters 11.1 (2016): 231-233.
Chicago
Kawasaki, K., Hamamoto, Y., Adachi, M., Kanai, T., Takaishi, H."Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report". Oncology Letters 11, no. 1 (2016): 231-233. https://doi.org/10.3892/ol.2015.3905