Cerebellar liponeurocytoma: A case report and review of the literature

Wang,Ke; Ni,Ming; Wang,Liang; Jia,Guijun; Wu,Zhen; Zhang,Liwei; Zhang,Junting

doi:10.3892/ol.2015.3986

February-2016 Volume 11 Issue 2

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February-2016 Volume 11 Issue 2

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Case Report

Cerebellar liponeurocytoma: A case report and review of the literature

Authors:
- Ke Wang
- Ming Ni
- Liang Wang
- Guijun Jia
- Zhen Wu
- Liwei Zhang
- Junting Zhang
View Affiliations / Copyright

Affiliations: Skull Base and Brainstem Tumor Division, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China
Pages: 1061-1064
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Published online on: December 2, 2015

https://doi.org/10.3892/ol.2015.3986
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Abstract

Cerebellar liponeurocytoma is rare, and the clinical characteristics and treatment strategy remain unclear. In the present study, a case of cerebellar liponeurocytoma was retrospectively reported and a literature review was performed. A 45-year-old female presented due to occipital headaches, exhibiting a hoarse voice and a broad‑based gait. Pre-operative magnetic resonance images revealed a lesion occupying the right hemisphere of the cerebellum and the inferior vermis, compressing the medulla oblongata from the right side, and extending through the foramen magnum to the C2 level. A total resection was performed, and pathological analysis of the lesion showed positivity for synaptophysin, S‑100 and neuronal nuclear antigen, partial positivity for Olig‑2, and negativity for glial fibrillary acidic protein and epithelial membrane antigen. In addition, the Ki‑67 index was low (<5%). Thus, a diagnosis of cerebellar liponeurocytoma was determined. Total resection was successful and the patient was followed up closely. A review of the literature showed that cerebellar liponeurocytoma is mainly located in the cerebellum, with rare extra‑cerebellar cases. Certain studies have suggested that the tumor may be located supratentorially and subtentorially, and should be renamed as solely liponeurocytoma. Total resection of the tumor contributes to an improved prognosis, while a subtotal resection and high Ki-67 index lead to recurrence. The tumor is similar to a tumor of low malignancy, with long-term recurrence. Radiation is recommended when there is residual tumor, recurrence or when the Ki-67 is high.

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1	Bechtel JT, Patton JM and Takei Y: Mixed mesenchymal and neuroectodermal tumor of the cerebellum. Acta Neuropathol. 41:261–263. 1978. View Article : Google Scholar : PubMed/NCBI
2	Limaiem F, Bellil S, Chelly I, Bellil K, Mekni A, Jemel H, Haouet S, Zitouna M and Kchir N: Recurrent cerebellar liponeurocytoma with supratentorial extension. Can J Neurol Sci. 36:662–665. 2009. View Article : Google Scholar : PubMed/NCBI
3	Aker FV, Ozkara S, Eren P, Peker O, Armağan S and Hakan T: Cerebellar liponeurocytoma/lipodized medulloblastoma. J Neurooncol. 71:53–59. 2005. View Article : Google Scholar : PubMed/NCBI
4	Patel N, Fallah A, Provias J and Jha NK: Cerebellar liponeurocytoma. Can J Surg. 52:E117–E119. 2009.PubMed/NCBI
5	Pankaj R, Jindal A and Banerjee AK: Liponeurocytoma of lateral ventricle. Neurol India. 58:805–806. 2010. View Article : Google Scholar : PubMed/NCBI
6	Karabagli P, Sav A and Pamir N: Does ‘cerebellar liponeurocytoma’ always reflect an expected site? An unusual case with a review of the literature. Folia Neuropathol. 52:101–105. 2014. View Article : Google Scholar : PubMed/NCBI
7	Kuchelmeister K, Nestler U, Siekmann R and Schachenmayr W: Liponeurocytoma of the left lateral ventricle - case report and review of the literature. Clin Neuropathol. 25:86–94. 2006.PubMed/NCBI
8	Anghileri E, Eoli M, Paterra R, Ferroli P, Pollo B, Cuccarini V, Maderna E, Tringali G, Saini M, Salsano E and Finocchiaro G: FABP4 is a candidate marker of cerebellar liponeurocytomas. J Neurooncol. 108:513–519. 2012. View Article : Google Scholar : PubMed/NCBI
9	Châtillon CE, Guiot MC, Roberge D and Leblanc R: Cerebellar liponeurocytoma with high proliferation index, Treatment options. Can J Neurol Sci. 36:658–661. 2009. View Article : Google Scholar : PubMed/NCBI
10	Jackson TR, Regine WF, Wilson D and Davis DG: Cerebellar liponeurocytoma. Histopathology. J Neurosurg. 95:700–703. 2001. View Article : Google Scholar : PubMed/NCBI
11	Genc A, Bozkurt SU, Karabagli P, Seker A, Bayri Y, Konya D and Kilic T: Gamma knife radiosurgery for cranial neurocytomas. J Neurooncol. 105:647–657. 2011. View Article : Google Scholar : PubMed/NCBI
12	Chung SB, Suh YL and Lee JI: Cerebellar liponeurocytoma with an unusually aggressive histopathology, Case report and review of the literature. J Korean Neurosurg Soc. 52:250–253. 2012. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cerebellar liponeurocytoma: A case report and review of the literature

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