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Article

Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors

  • Authors:
    • Carsten Nieder
    • Kirsten Marienhagen
    • Roy M. Kristensen
    • Torbjørn Sørbye
    • Lars Hoem
  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø 8092, Norway, Department of Oncology, University Hospital of North Norway, Tromsø 9038, Norway, Department of Urology, Nordland Hospital, Bodø 8092, Norway
  • Pages: 1138-1142
    |
    Published online on: December 4, 2015
       https://doi.org/10.3892/ol.2015.4005
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Abstract

Salvage radiotherapy for post-prostatectomy biochemical recurrence does not always control the disease. It would be useful to identify patients who would not benefit from radiotherapy to the prostate bed prior to making treatment recommendations. One such group of patients is those who experience continuously rising prostate‑specific antigen (PSA) despite radiotherapy. The purpose of this study was to identify risk factors for continuous PSA increase and the pattern of radiological relapse during follow‑up. We performed a retrospective comparison of two patient groups with PSA decline or continuous increase following salvage radiotherapy to the prostate bed. All patients received 3‑D conformal radiotherapy (35 fractions of 2 Gy). Patients with continuous PSA increase were more likely to have had complete surgical resection (negative margins) and a shorter interval to radiotherapy (<24 months). However, the only statistically significant risk factor was Gleason score. Sixty‑four percent of patients with a Gleason score of 9 developed continuously increasing PSA, indicating that residual subclinical cancer was not located in the prostate bed. The median time to radiological recurrence was 43 months. Isolated pelvic nodal recurrence was uncommon. Almost all patients with radiological recurrence had high‑risk disease, in particular stage pT3. In conclusion, the majority of patients with biologically aggressive tumors with Gleason score 9 were not adequately treated with prostate bed radiotherapy alone. The predominant pattern of radiological recurrence was outside of the pelvis. Therefore, the problem of distant micrometastases has to be addressed.
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1 

De Meerleer G, Fonteyne V, Meersschout S, et al: Salvage intensity-modulated radiotherapy for rising PSA after radical prostatectomy. Radiother Oncol. 89:205–213. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Bernard JR Jr, Buskirk SJ, Heckman MG, et al: Salvage radiotherapy for rising prostate-specific antigen levels after radical prostatectomy for prostate cancer: dose-response analysis. Int J Radiat Oncol Biol Phys. 76:735–740. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Trock BJ, Han M, Freedland SJ, et al: Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. JAMA. 299:2760–2769. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Jereczek-Fossa BA, Zerini D, Vavassori A, et al: Sooner or later? Outcome analysis of 431 prostate cancer patients treated with postoperative or salvage radiotherapy. Int J Radiat Oncol Biol Phys. 74:115–125. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Valicenti RK, Thompson I Jr, Albertsen P, et al: Adjuvant and salvage radiation therapy after prostatectomy: American Society for Radiation Oncology/American Urological Association guidelines. Int J Radiat Oncol Biol Phys. 86:822–888. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Shelan M, Abo-Madyan Y, Welzel G, et al: Dose-escalated salvage radiotherapy after radical prostatectomy in high risk prostate cancer patients without hormone therapy: outcome, prognostic factors and late toxicity. Radiat Oncol. 8:2762013. View Article : Google Scholar : PubMed/NCBI

7 

Stephenson AJ, Scardino PT, Kattan MW, et al: Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy. J Clin Oncol. 25:2035–2041. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Macdonald OK, D'Amico AV, Sadetsky N, Shrieve DC and Carroll PR: Predicting PSA failure following salvage radiotherapy for a rising PSA post-prostatectomy: from the CaPSURE database. Urol Oncol. 26:271–275. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Moreira DM, Jayachandran J, Presti JC Jr, et al: Validation of a nomogram to predict disease progression following salvage radiotherapy after radical prostatectomy: results from the SEARCH database. BJU Int. 104:1452–1456. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Lohm G, Lütcke J, Jamil B, et al: Salvage radiotherapy in patients with prostate cancer and biochemical relapse after radical prostatectomy: long-term follow-up of a single-center survey. Strahlenther Onkol. 190:727–731. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Geinitz H, Riegel MG, Thamm R, et al: Outcome after conformal salvage radiotherapy in patients with rising prostate-specific antigen levels after radical prostatectomy. Int J Radiat Oncol Biol Phys. 82:1930–1937. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Wiegel T, Lohm G, Bottke D, et al: Achieving an undetectable PSA after radiotherapy for biochemical progression after radical prostatectomy is an independent predictor of biochemical outcome-results of a retrospective study. Int J Radiat Oncol Biol Phys. 73:1009–1016. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Miyake M, Tanaka N, Asakawa I, et al: Proposed salvage treatment strategy for biochemical failure after radical prostatectomy in patients with prostate cancer: a retrospective study. Radiat Oncol. 9:2082014. View Article : Google Scholar : PubMed/NCBI

14 

Ceci F, Herrmann K, Castellucci P, et al: Impact of (11) C-choline PET/CT on clinical decision making in recurrent prostate cancer: results from a retrospective two-centre trial. Eur J Nucl Med Mol Imaging. 41:2222–2231. 2014. View Article : Google Scholar : PubMed/NCBI

15 

D'Angelillo RM, Sciuto R, Ramella S, et al: 18F-choline positron emission tomography/computed tomography-driven high-dose salvage radiation therapy in patients with biochemical progression after radical prostatectomy: feasibility study in 60 patients. Int J Radiat Oncol Biol Phys. 90:296–302. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Rischke HC, Schäfer AO, Nestle U, et al: Detection of local recurrent prostate cancer after radical prostatectomy in terms of salvage radiotherapy using dynamic contrast enhanced-MRI without endorectal coil. Radiat Oncol. 7:1852012. View Article : Google Scholar : PubMed/NCBI

17 

Beresford MJ, Gillatt D, Benson RJ and Ajithkumar T: A systematic review of the role of imaging before salvage radiotherapy for post-prostatectomy biochemical recurrence. Clin Oncol (R Coll Radiol). 22:46–55. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Bolla M, van Poppel H, Collette L, et al: Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911). Lancet. 366:572–578. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Thompson IM Jr, Tangen CM, Paradelo J, et al: Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial. JAMA. 296:2329–2335. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Wiegel T, Bottke D, Steiner U, et al: Phase III postoperative adjuvant radiotherapy after radical prostatectomy compared with radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02/AUO AP 09/95. J Clin Oncol. 27:2924–2930. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Choo R, Danjoux C, Gardner S, et al: Efficacy of salvage radiotherapy plus 2-year androgen suppression for postradical prostatectomy patients with PSA relapse. Int J Radiat Oncol Biol Phys. 75:983–989. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Pai HH, Eldridge B, Bishop D, et al: Does neoadjuvant hormone therapy improve outcome in prostate cancer patients receiving radiotherapy after radical prostatectomy? Can J Urol. 16:4541–4552. 2009.PubMed/NCBI

23 

Leung CM, Li SC, Chen TW, et al: Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. Oncol Rep. 31:1067–1078. 2014.PubMed/NCBI

24 

Guttilla A, Bortolus R, Giannarini G, et al: Multimodal treatment for high-risk prostate cancer with high-dose intensity-modulated radiation therapy preceded or not by radical prostatectomy, concurrent intensified-dose docetaxel and long-term androgen deprivation therapy: results of a prospective phase II trial. Radiat Oncol. 9:242014. View Article : Google Scholar : PubMed/NCBI

25 

Grenader T, Plotkin Y, Gips M, Cherny N and Gabizon A: Diethylstilbestrol for the treatment of patients with castration-resistant prostate cancer, Retrospective analysis of a single institution experience. Oncol Rep. 31:428–434. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nieder C, Marienhagen K, Kristensen RM, Sørbye T and Hoem L: Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors. Oncol Lett 11: 1138-1142, 2016.
APA
Nieder, C., Marienhagen, K., Kristensen, R.M., Sørbye, T., & Hoem, L. (2016). Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors. Oncology Letters, 11, 1138-1142. https://doi.org/10.3892/ol.2015.4005
MLA
Nieder, C., Marienhagen, K., Kristensen, R. M., Sørbye, T., Hoem, L."Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors". Oncology Letters 11.2 (2016): 1138-1142.
Chicago
Nieder, C., Marienhagen, K., Kristensen, R. M., Sørbye, T., Hoem, L."Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors". Oncology Letters 11, no. 2 (2016): 1138-1142. https://doi.org/10.3892/ol.2015.4005
Copy and paste a formatted citation
x
Spandidos Publications style
Nieder C, Marienhagen K, Kristensen RM, Sørbye T and Hoem L: Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors. Oncol Lett 11: 1138-1142, 2016.
APA
Nieder, C., Marienhagen, K., Kristensen, R.M., Sørbye, T., & Hoem, L. (2016). Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors. Oncology Letters, 11, 1138-1142. https://doi.org/10.3892/ol.2015.4005
MLA
Nieder, C., Marienhagen, K., Kristensen, R. M., Sørbye, T., Hoem, L."Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors". Oncology Letters 11.2 (2016): 1138-1142.
Chicago
Nieder, C., Marienhagen, K., Kristensen, R. M., Sørbye, T., Hoem, L."Continuous prostate-specific antigen rise despite salvage radiotherapy following radical prostatectomy: Pattern of clinical relapse and predictive factors". Oncology Letters 11, no. 2 (2016): 1138-1142. https://doi.org/10.3892/ol.2015.4005
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