Diverse microRNAs with convergent functions regulate tumorigenesis (Review)

  • Authors:
    • Min‑Yan Zhu
    • Wei Zhang
    • Tao Yang
  • View Affiliations

  • Published online on: December 9, 2015     https://doi.org/10.3892/ol.2015.4020
  • Pages: 915-920
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Abstract

MicroRNAs (miRNAs) regulate several biological processes, including tumorigenesis. In order to comprehend the roles of miRNAs in cancer, various screens were performed to investigate the changes in the expression levels of miRNAs that occur in different types of cancer. The present review focuses on the results of five recent screens, whereby a number of overlapping miRNAs were identified to be downregulated or differentially regulated, whereas no miRNAs were observed to be frequently upregulated. Furthermore, the majority of the miRNAs that were common to >1 screen were involved in signaling networks, including wingless‑related integration site, receptor tyrosine kinase and transforming growth factor‑β, or in cell cycle checkpoint control. The present review will discuss the aforementioned miRNAs implicated in cell cycle checkpoint control and signaling networks.
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February-2016
Volume 11 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhu MY, Zhang W and Yang T: Diverse microRNAs with convergent functions regulate tumorigenesis (Review). Oncol Lett 11: 915-920, 2016
APA
Zhu, M., Zhang, W., & Yang, T. (2016). Diverse microRNAs with convergent functions regulate tumorigenesis (Review). Oncology Letters, 11, 915-920. https://doi.org/10.3892/ol.2015.4020
MLA
Zhu, M., Zhang, W., Yang, T."Diverse microRNAs with convergent functions regulate tumorigenesis (Review)". Oncology Letters 11.2 (2016): 915-920.
Chicago
Zhu, M., Zhang, W., Yang, T."Diverse microRNAs with convergent functions regulate tumorigenesis (Review)". Oncology Letters 11, no. 2 (2016): 915-920. https://doi.org/10.3892/ol.2015.4020