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Article

Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis

  • Authors:
    • Luigi Zugaro
    • Mario Di Staso
    • Giovanni Luca Gravina
    • Pierluigi Bonfili
    • Lorenzo Gregori
    • Pietro Franzese
    • Francesco Marampon
    • Vincenzo Tombolini
    • Ernesto Di Cesare
    • Carlo Masciocchi
  • View Affiliations / Copyright

    Affiliations: Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, San Salvatore Hospital, University of L'Aquila Medical School, L'Aquila 67100, Italy, Department of Biotechnological and Applied Clinical Sciences, Division of Radiation Oncology and Radiobiology, San Salvatore Hospital, University of L'Aquila Medical School, L'Aquila 67100, Italy, Department of Radiological, Oncological and Anatomopathological Sciences, 'Sapienza' University, Rome 00185, Italy
  • Pages: 1948-1954
    |
    Published online on: January 14, 2016
       https://doi.org/10.3892/ol.2016.4108
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Abstract

The present study aimed to measure the improvement in pain relief and quality of life in patients with osteolytic solitary painful bone metastasis treated by cryoablation (CA) or radiofrequency ablation (RFA). Fifty patients with solitary osteolytic painful bone metastases were retrospectively studied and selected by propensity analysis. Twenty‑five patients underwent CA and the remaining twenty‑five underwent RFA. Pain relief, in terms of complete response (CR), the number of patients requiring analgesia and the changes in self‑rated quality of life (QoL) were measured following the two treatments. Thirty‑two percent of patients treated by CA experienced a CR at 12 weeks versus 20% of patients treated by RFA. The rate of CR increased significantly with respect to baseline only in the group treated by CA. In both groups there was a significant change in the partial response with respect to baseline (36% in the CA group vs. 44% in the RFA group). The recurrence rate in the CA and RFA groups was 12% and 8%, respectively. The reduction in narcotic medication requirements with respect to baseline was only significant in the group treated by CA. A significant improvement in self‑rated QoL was observed in both groups. The present study seems to suggest that CA only significantly improves the rate of CR and decreases the requirement of narcotic medications. Both CA and RFA led to an improvement in the self‑rated QoL of patients after the treatments. However, the results of the present study should be considered as preliminary and to serve as a framework around which future trials may be designed.
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1 

Suva LJ, Washam C, Nicholas RW and Griffin RJ: Bone metastasis: Mechanisms and therapeutic opportunities. Nat Rev Endocrinol. 7:208–218. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Roodman GD: Mechanisms of bone metastasis. N Engl J Med. 350:1655–1664. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Suva LJ, Griffin RJ and Makhoul I: Mechanisms of bone metastases of breast cancer. Endocr Relat Cancer. 16:703–713. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Coleman RE: Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 12:6243s–6249s. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Coleman RE: Metastatic bone disease: Clinical features, pathophysiology and treatment strategies. Cancer Treat Rev. 27:165–176. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Harvey HA and Cream LV: Biology of bone metastases: Causes and consequences. Clin Breast Cancer. 7(Suppl 1): S7–S13. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Smith HS: Painful osseous metastases. Pain Physician. 14:E373–E403. 2011.PubMed/NCBI

8 

Tharmalingam S, Chow E, Harris K, Hird A and Sinclair E: Quality of life measurement in bone metastases: A literature review. J Pain Res. 1:49–58. 2008.PubMed/NCBI

9 

Yu HH, Tsai YY and Hoffe SE: Overview of diagnosis and management of metastatic disease to bone. Cancer Control. 19:84–91. 2012.PubMed/NCBI

10 

Lutz S, Berk L, Chang E, Chow E, Hahn C, Hoskin P, Howell D, Konski A, Kachnic L, Lo S, et al: American Society for Radiation Oncology (ASTRO). Palliative radiotherapy for bone metastases: An ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys. 79:965–76. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Andrade RS, Proctor JW, Slack R, Marlowe U, Ashby KR and Schenken LL: A simple and effective daily pain management method for patients receiving radiation therapy for painful bone metastases. Int J Radiat Oncol Biol Phys. 78:855–859. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Widmann G, Bodner G and Bale R: Tumour ablation: Technical aspects. Cancer Imaging. 9:63–67. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Goetz MP, Callstrom MR, Charboneau JW, Farrell MA, Maus TP, Welch TJ, Wong GY, Sloan JA, Novotny PJ, Petersen IA, et al: Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: A multicenter study. J Clin Oncol. 22:300–306. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Silverman SG, Tuncali K, Adams DF, vanSonnenberg E, Zou KH, Kacher DF, Morrison PR and Jolesz FA: MR imaging-guided percutaneous cryotherapy of liver tumors: Initial experience. Radiology. 217:657–664. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Callstrom MR, Charboneau JW, Goetz MP, Rubin J, Wong GY, Sloan JA, Novotny PJ, Lewis BD, Welch TJ, Farrell MA, et al: Painful metastases involving bone: Feasibility of percutaneous CT- and US-guided radio-frequency ablation. Radiology. 224:87–97. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Dupuy DE, Liu D, Hartfeil D, Hanna L, Blume JD, Ahrar K, Lopez R, Safran H and DiPetrillo T: Percutaneous radiofrequency ablation of painful osseous metastases: A multicenter American College of Radiology Imaging Network trial. Cancer. 116:989–997. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Rosenthal D and Callstrom MR: Critical review and state of the art in interventional oncology: Benign and metastatic disease involving bone. Radiology. 262:765–80. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Grieco CA, Simon CJ, Mayo-Smith WW, Dipetrillo TA, Ready NE and Dupuy DE: Image-guided percutaneous thermal ablation for the palliative treatment of chest wall masses. Am J Clin Oncol. 30:361–367. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Di Staso M, Zugaro L, Gravina GL, Bonfili P, Marampon F, Di Nicola L, Conchiglia A, Ventura L, Franzese P, Gallucci M, et al: A feasibility study of percutaneous Radiofrequency Ablation followed by Radiotherapy in the management of painful osteolytic bone metastases. Eur Radiol. 21:2004–2010. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Di Staso M, Zugaro L, Gravina GL, Bonfili P, Marampon F, Di Nicola L, Conchiglia A, Franzese P, Gallucci M, Masciocchi C, et al: Can radiotherapy be combined with radiofrequency ablation in the management of symptomatic osteolytic skeletal metastasis? Clin Oncol (R Coll Radiol). 23:65–66. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Cohen SR, Mount BM, Strobel MG and Bui F: The McGill Quality of Life Questionnaire: A measure of quality of life appropriate for people with advanced disease. A preliminary study of validity and acceptability. Palliat Med. 9:207–219. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Sacks D, McClenny TE, Cardella JF and Lewis CA: Society of Interventional Radiology clinical practice guidelines. J Vasc Interv Radiol. 14:S199–S202. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Chow E, Wu JS, Hoskin P, Coia LR, Bentzen SM and Blitzer PH: International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol. 64:275–280. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Callstrom MR, Dupuy DE, Solomon SB, Beres RA, Littrup PJ, Davis KW, Paz-Fumagalli R, Hoffman C, Atwell TD, Charboneau JW, et al: Percutaneous image-guided cryoablation of painful metastases involving bone: Multicenter trial. Cancer. 119:1033–1041. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Callstrom MR, Atwell TD, Charboneau JW, Farrell MA, Goetz MP, Rubin J, Sloan JA, Novotny PJ, Welch TJ, Maus TP, et al: Painful metastases involving bone: Percutaneous image-guided cryoablation-prospective trial interim analysis. Radiology. 241:572–580. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zugaro L, Di Staso M, Gravina GL, Bonfili P, Gregori L, Franzese P, Marampon F, Tombolini V, Di Cesare E, Masciocchi C, Masciocchi C, et al: Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis. Oncol Lett 11: 1948-1954, 2016.
APA
Zugaro, L., Di Staso, M., Gravina, G.L., Bonfili, P., Gregori, L., Franzese, P. ... Masciocchi, C. (2016). Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis. Oncology Letters, 11, 1948-1954. https://doi.org/10.3892/ol.2016.4108
MLA
Zugaro, L., Di Staso, M., Gravina, G. L., Bonfili, P., Gregori, L., Franzese, P., Marampon, F., Tombolini, V., Di Cesare, E., Masciocchi, C."Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis". Oncology Letters 11.3 (2016): 1948-1954.
Chicago
Zugaro, L., Di Staso, M., Gravina, G. L., Bonfili, P., Gregori, L., Franzese, P., Marampon, F., Tombolini, V., Di Cesare, E., Masciocchi, C."Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis". Oncology Letters 11, no. 3 (2016): 1948-1954. https://doi.org/10.3892/ol.2016.4108
Copy and paste a formatted citation
x
Spandidos Publications style
Zugaro L, Di Staso M, Gravina GL, Bonfili P, Gregori L, Franzese P, Marampon F, Tombolini V, Di Cesare E, Masciocchi C, Masciocchi C, et al: Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis. Oncol Lett 11: 1948-1954, 2016.
APA
Zugaro, L., Di Staso, M., Gravina, G.L., Bonfili, P., Gregori, L., Franzese, P. ... Masciocchi, C. (2016). Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis. Oncology Letters, 11, 1948-1954. https://doi.org/10.3892/ol.2016.4108
MLA
Zugaro, L., Di Staso, M., Gravina, G. L., Bonfili, P., Gregori, L., Franzese, P., Marampon, F., Tombolini, V., Di Cesare, E., Masciocchi, C."Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis". Oncology Letters 11.3 (2016): 1948-1954.
Chicago
Zugaro, L., Di Staso, M., Gravina, G. L., Bonfili, P., Gregori, L., Franzese, P., Marampon, F., Tombolini, V., Di Cesare, E., Masciocchi, C."Treatment of osteolytic solitary painful osseous metastases with radiofrequency ablation or cryoablation: A retrospective study by propensity analysis". Oncology Letters 11, no. 3 (2016): 1948-1954. https://doi.org/10.3892/ol.2016.4108
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