Luteinizing hormone inhibits cisplatin‑induced apoptosis in human epithelial ovarian cancer cells

  • Authors:
    • Lingfang Xia
    • Hao Wen
    • Xiaotian Han
    • Jia Tang
    • Yan Huang
  • View Affiliations

  • Published online on: January 18, 2016     https://doi.org/10.3892/ol.2016.4122
  • Pages: 1943-1947
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Abstract

The elevation of Luteinizing hormone (LH) is commonly observed in epithelial ovarian cancer. This correlation suggests a causal relationship between LH and ovarian cancer. LH has been reported to inhibit apoptosis in ovarian cancer cells. Programmed cell death gene 6 (PDCD6), also known as apoptosis‑linked gene‑2, is an apoptotic mediator that is required for apoptosis to numerous death stimuli. Therefore, the aim of the present study was to determine whether PDCD6 may be induced by LH in ovarian cancer, and whether LH may affect the apoptosis through PDCD6. Flow cytometry was used to detect the effects of cisplatin on the induction of apoptosis by LH. PDCD6 expression was monitored by quantitative polymerase chain reaction and western blotting. The signaling transduction pathways were also investigated by western blotting. The present study demonstrated that LH reduced cisplatin‑induced apoptosis in ovarian OVCAR‑3 and SKOV‑3 cancer cells. The results indicated that PDCD6 expression was inhibited by LH. In addition, the inhibition of PDCD6, induced by LH, was mediated through the activation of the phosphatidylinositol 3‑kinase/protein kinase B and p44/42 mitogen‑activated protein kinase transduction signaling pathways. The present results suggest that LH affects the sensitivity of ovarian cancer cells to chemotherapy, primarily by signaling to inhibit apoptosis and to additionally suppress PDCD6.
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March-2016
Volume 11 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xia L, Wen H, Han X, Tang J and Huang Y: Luteinizing hormone inhibits cisplatin‑induced apoptosis in human epithelial ovarian cancer cells. Oncol Lett 11: 1943-1947, 2016
APA
Xia, L., Wen, H., Han, X., Tang, J., & Huang, Y. (2016). Luteinizing hormone inhibits cisplatin‑induced apoptosis in human epithelial ovarian cancer cells. Oncology Letters, 11, 1943-1947. https://doi.org/10.3892/ol.2016.4122
MLA
Xia, L., Wen, H., Han, X., Tang, J., Huang, Y."Luteinizing hormone inhibits cisplatin‑induced apoptosis in human epithelial ovarian cancer cells". Oncology Letters 11.3 (2016): 1943-1947.
Chicago
Xia, L., Wen, H., Han, X., Tang, J., Huang, Y."Luteinizing hormone inhibits cisplatin‑induced apoptosis in human epithelial ovarian cancer cells". Oncology Letters 11, no. 3 (2016): 1943-1947. https://doi.org/10.3892/ol.2016.4122