High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia

  • Authors:
    • Rabab M. Aly
    • Mona M. Taalab
    • Eman M. Abdsalam
    • Omar H. Elyamany
    • Omar E. Hasan
  • View Affiliations

  • Published online on: January 19, 2016     https://doi.org/10.3892/ol.2016.4127
  • Pages: 1917-1922
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Abstract

The LIM domain only protein 2 (LMO2) is a key regulator of hematopoietic stem cell development. Expression of LMO2 has been evaluated in B-cell lymphoma, T-cell acute lymphoblastic leukemia and acute myeloid leukemia; however, information concerning its role in breakpoint cluster region/Abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) negative B-cell acute lymphoblastic leukemia (B‑ALL) remains limited. The present study investigated LMO2 expression using quantitative polymerase chain reaction in 85 adult patients with BCR/ABL negative B‑ALL, and associated the expression of LMO2 with established prognostic factors. LMO2 expression levels in patients with BCR/ABL negative B‑ALL was not significantly different compared with control individuals (P=0.25). However, LMO2 expression levels were associated with the immunophenotypical features of the patients; a high LMO2 expression was associated with a higher incidence of complete remission (P=0.03) and lower rate of relapse (P=0.01), and patients with a high LMO2 expression had a significantly improved overall survival rate (P=0.01) and disease‑free survival (P=0.01). The present results suggest that LMO2 expression is a favorable prognostic marker in adult patients with BCR/ABL negative B‑ALL and may be used as a diagnostic marker and therapeutic target. However, additional studies regarding its prognostic role in patients with BCR/ABL negative B-ALL are required.
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March-2016
Volume 11 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Aly RM, Taalab MM, Abdsalam EM, Elyamany OH and Hasan OE: High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia. Oncol Lett 11: 1917-1922, 2016
APA
Aly, R.M., Taalab, M.M., Abdsalam, E.M., Elyamany, O.H., & Hasan, O.E. (2016). High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia. Oncology Letters, 11, 1917-1922. https://doi.org/10.3892/ol.2016.4127
MLA
Aly, R. M., Taalab, M. M., Abdsalam, E. M., Elyamany, O. H., Hasan, O. E."High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia". Oncology Letters 11.3 (2016): 1917-1922.
Chicago
Aly, R. M., Taalab, M. M., Abdsalam, E. M., Elyamany, O. H., Hasan, O. E."High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia". Oncology Letters 11, no. 3 (2016): 1917-1922. https://doi.org/10.3892/ol.2016.4127