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Article

High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia

  • Authors:
    • Rabab M. Aly
    • Mona M. Taalab
    • Eman M. Abdsalam
    • Omar H. Elyamany
    • Omar E. Hasan
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura 31115, Egypt, Clinical Hematology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura 31115, Egypt, General Medicine Department, Faculty of Medicine For Girls, Alazhar University, Cairo 31991, Egypt, Department of General Medicine, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
  • Pages: 1917-1922
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    Published online on: January 19, 2016
       https://doi.org/10.3892/ol.2016.4127
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Abstract

The LIM domain only protein 2 (LMO2) is a key regulator of hematopoietic stem cell development. Expression of LMO2 has been evaluated in B-cell lymphoma, T-cell acute lymphoblastic leukemia and acute myeloid leukemia; however, information concerning its role in breakpoint cluster region/Abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) negative B-cell acute lymphoblastic leukemia (B‑ALL) remains limited. The present study investigated LMO2 expression using quantitative polymerase chain reaction in 85 adult patients with BCR/ABL negative B‑ALL, and associated the expression of LMO2 with established prognostic factors. LMO2 expression levels in patients with BCR/ABL negative B‑ALL was not significantly different compared with control individuals (P=0.25). However, LMO2 expression levels were associated with the immunophenotypical features of the patients; a high LMO2 expression was associated with a higher incidence of complete remission (P=0.03) and lower rate of relapse (P=0.01), and patients with a high LMO2 expression had a significantly improved overall survival rate (P=0.01) and disease‑free survival (P=0.01). The present results suggest that LMO2 expression is a favorable prognostic marker in adult patients with BCR/ABL negative B‑ALL and may be used as a diagnostic marker and therapeutic target. However, additional studies regarding its prognostic role in patients with BCR/ABL negative B-ALL are required.
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Copy and paste a formatted citation
Spandidos Publications style
Aly RM, Taalab MM, Abdsalam EM, Elyamany OH and Hasan OE: High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia. Oncol Lett 11: 1917-1922, 2016.
APA
Aly, R.M., Taalab, M.M., Abdsalam, E.M., Elyamany, O.H., & Hasan, O.E. (2016). High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia. Oncology Letters, 11, 1917-1922. https://doi.org/10.3892/ol.2016.4127
MLA
Aly, R. M., Taalab, M. M., Abdsalam, E. M., Elyamany, O. H., Hasan, O. E."High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia". Oncology Letters 11.3 (2016): 1917-1922.
Chicago
Aly, R. M., Taalab, M. M., Abdsalam, E. M., Elyamany, O. H., Hasan, O. E."High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia". Oncology Letters 11, no. 3 (2016): 1917-1922. https://doi.org/10.3892/ol.2016.4127
Copy and paste a formatted citation
x
Spandidos Publications style
Aly RM, Taalab MM, Abdsalam EM, Elyamany OH and Hasan OE: High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia. Oncol Lett 11: 1917-1922, 2016.
APA
Aly, R.M., Taalab, M.M., Abdsalam, E.M., Elyamany, O.H., & Hasan, O.E. (2016). High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia. Oncology Letters, 11, 1917-1922. https://doi.org/10.3892/ol.2016.4127
MLA
Aly, R. M., Taalab, M. M., Abdsalam, E. M., Elyamany, O. H., Hasan, O. E."High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia". Oncology Letters 11.3 (2016): 1917-1922.
Chicago
Aly, R. M., Taalab, M. M., Abdsalam, E. M., Elyamany, O. H., Hasan, O. E."High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia". Oncology Letters 11, no. 3 (2016): 1917-1922. https://doi.org/10.3892/ol.2016.4127
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