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March-2016 Volume 11 Issue 3

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Review

Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review)

  • Authors:
    • Danyang Ren
    • Huiying Li
    • Renqiu Li
    • Jianming Sun
    • Pin Guo
    • Huiyun Han
    • Yuehuang Yang
    • Jun Li
  • View Affiliations / Copyright

    Affiliations: Pharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, Yunnan 650034, P.R. China, Department of Hematology, Children's Hospital of Kunming Medical University, Kunming, Yunnan 650034, P.R. China, Department of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China
  • Pages: 1621-1630
    |
    Published online on: January 22, 2016
       https://doi.org/10.3892/ol.2016.4138
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Abstract

Long non-protein-coding RNAs (lncRNAs) are emerging as important gene expression regulators that are linked to various biological processes at the post‑transcriptional and transcriptional levels. lncRNAs are known to be important in cell proliferation, cell differentiation, apoptosis and metastasis. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT‑1), a novel lncRNA, is highly conserved amongst mammals. In addition, it has been considered to act as an oncogene, depending on the tumor system. An increasing number of studies have indicated that MALAT‑1 may be detected in certain types of human tumors, including lung and bladder cancer and hepatocellular carcinoma. MALAT‑1 silencing may be an effective therapeutic approach against tumors. The present study reviews the current knowledge on the functional role of MALAT-1 in the control of various cancers.
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Copy and paste a formatted citation
Spandidos Publications style
Ren D, Li H, Li R, Sun J, Guo P, Han H, Yang Y and Li J: Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review). Oncol Lett 11: 1621-1630, 2016.
APA
Ren, D., Li, H., Li, R., Sun, J., Guo, P., Han, H. ... Li, J. (2016). Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review). Oncology Letters, 11, 1621-1630. https://doi.org/10.3892/ol.2016.4138
MLA
Ren, D., Li, H., Li, R., Sun, J., Guo, P., Han, H., Yang, Y., Li, J."Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review)". Oncology Letters 11.3 (2016): 1621-1630.
Chicago
Ren, D., Li, H., Li, R., Sun, J., Guo, P., Han, H., Yang, Y., Li, J."Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review)". Oncology Letters 11, no. 3 (2016): 1621-1630. https://doi.org/10.3892/ol.2016.4138
Copy and paste a formatted citation
x
Spandidos Publications style
Ren D, Li H, Li R, Sun J, Guo P, Han H, Yang Y and Li J: Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review). Oncol Lett 11: 1621-1630, 2016.
APA
Ren, D., Li, H., Li, R., Sun, J., Guo, P., Han, H. ... Li, J. (2016). Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review). Oncology Letters, 11, 1621-1630. https://doi.org/10.3892/ol.2016.4138
MLA
Ren, D., Li, H., Li, R., Sun, J., Guo, P., Han, H., Yang, Y., Li, J."Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review)". Oncology Letters 11.3 (2016): 1621-1630.
Chicago
Ren, D., Li, H., Li, R., Sun, J., Guo, P., Han, H., Yang, Y., Li, J."Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications (Review)". Oncology Letters 11, no. 3 (2016): 1621-1630. https://doi.org/10.3892/ol.2016.4138
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