Cutaneous and systemic plasmacytosis on the face: Effective treatment of a case using thalidomide

Fang,Sheng; Shan,Kui; Chen,Ai‑Jun

doi:10.3892/ol.2016.4140

Cutaneous and systemic plasmacytosis on the face: Effective treatment of a case using thalidomide

Authors:
- Sheng Fang
- Kui Shan
- Ai‑Jun Chen
View Affiliations

Affiliations: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
Published online on: January 25, 2016 https://doi.org/10.3892/ol.2016.4140
Pages: 1923-1925

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Cutaneous and systemic plasmacytosis is an exceedingly rare condition that is identified in Japanese individuals in particular. The present study describes the case of a patient of mainland Chinese origin who manifested with red-brown macules, papules and plaques limited to the face. Identifying a therapy for cutaneous and systemic plasmacytosis is quite difficult, however, the present patient showed a good response to low‑dose thalidomide. The exact mechanism of action is not yet clear, however, we hypothesize that thalidomide may function through decreasing the secretion of interleukin‑6 and affecting the growth of plasma cells.

View Figures

View References

1	Tada Y, Komine M, Suzuki S, Kikuchi K, Sasaki M, Kaneko N and Tamaki K: Plasmacytosis: Systemic or cutaneous, are they distinct? Acta Derm Venereol. 80:233–235. 2000. View Article : Google Scholar : PubMed/NCBI
2	Carey WP, Rico MJ, Nierodzik M and Sidhu G: Systemic plasmacytosis with cutaneous manifestations in a white man: Successful therapy with cyclophosphamide/prednisone. J Am Acad Dermatol. 38:629–631. 1998. View Article : Google Scholar : PubMed/NCBI
3	Honda R, Cerroni L, Tanikawa A, Ebihara T, Amagai M and Ishiko A: Cutaneous plasmacytosis: Report of 6 cases with or without systemic involvement. J Am Acad Dermatol. 68:978–985. 2013. View Article : Google Scholar : PubMed/NCBI
4	Leonard AL, Meehan SA, Ramsey D, Brown L and Sen F: Cutaneous and systemic plasmacytosis. J Am Acad Dermatol. 56(Suppl): S38–S40. 2007. View Article : Google Scholar : PubMed/NCBI
5	Jayaraman AG, Cesca C and Kohler S: Cutaneous plasmacytosis: A report of five cases with immunohistochemical evaluation for HHV-8 expression. Am J Dermatopathol. 28:93–98. 2006. View Article : Google Scholar : PubMed/NCBI
6	Yashiro A: A kind of plasmacytosis: Primary cutaneous plasmacytoma? Jpn J Dermatol. 86:9101976.
7	Kitamura K, Tamura N, Hatano H, Toyama K, Mikata A and Watanabe S: A case of plasmacytosis with multiple peculiar eruptions. J Dermatol. 7:341–349. 1980. View Article : Google Scholar : PubMed/NCBI
8	Uhara H, Saida T, Ikegawa S, Yamazaki Y, Mikoshiba H, Nijoh S, Kitano K and Koh CS: Primary cutaneous plasmacytosis: Report of three cases and review of the literature. Dermatology. 189:251–2551994. View Article : Google Scholar
9	Wagner G, Rose C, Klapper W and Sachse MM: Cutaneous and systemic plasmocytosis. J Dtsch Dermatol Ges. 11:1161–1167. 2013. View Article : Google Scholar : PubMed/NCBI
10	Ma HJ, Liu W, Li Y, Zhao G, Meng RS and Li DG: Cutaneous and systemic plasmacytosis: A Chinese case. J Dermatol. 35:536–540. 2008. View Article : Google Scholar : PubMed/NCBI
11	González-López MA, González-Vela MC, Blanco R, Fernández-Llaca H and Val-Bernal JF: Cutaneous plasmacytosis limited to the extremities in a white patient: An unusual clinical picture. Cutis. 86:143–147. 2010.PubMed/NCBI
12	Ahn JJ, Yang YS, Shin MK, Lee SW and Kim NI: Case of isolated benign primary cutaneous plasmacytosis in a child. J Dermatol. 38:364–367. 2011. View Article : Google Scholar : PubMed/NCBI
13	Yamamoto T, Katayama I and Nishioka K: Increased plasma interleukin-6 in cutaneous plasmacytoma: The effect of intralesional steroid therapy. Br J Dermatol. 137:631–636. 1997. View Article : Google Scholar : PubMed/NCBI
14	Miura H, Itami S and Yoshikawa K: Treatment of facial lesion of cutaneous plasmacytosis with tacrolimus ointment. J Am Acad Dermatol. 49:1195–1196. 2003. View Article : Google Scholar : PubMed/NCBI
15	Hafner C, Hohenleutner U, Babilas P, Landthaler M and Vogt T: Targeting T cells to hit B cells: Successful treatment of cutaneous plasmacytosis with topical pimecrolimus. Dermatology. 213:163–165. 2006. View Article : Google Scholar : PubMed/NCBI
16	Tzung TY, Wu KH, Wu JC and Tseng HH: Primary cutaneous plasmacytosis successfully treated with topical photodynamic therapy. Acta Derm Venereol. 85:542–543. 2005.PubMed/NCBI
17	Amin HM, McLaughlin P, Rutherford CJ, Abruzzo LV and Jones D: Cutaneous and systemic plasmacytosis in a patient of Asian descent living in the United States. Am J Dermatopathol. 24:241–245. 2002. View Article : Google Scholar : PubMed/NCBI
18	Lee DW, Choi SW, Park JW and Cho BK: Systemic plasmacytosis: A case which improved with melphalan. J Dermatol. 22:205–209. 1995. View Article : Google Scholar : PubMed/NCBI
19	Berrebi A, Feldberg E, Spivak I and Shvidel L: Mini-dose of thalidomide for treatment of primary myelofibrosis. Report of a case with complete reversal of bone marrow fibrosis and splenomegaly. Haematologica:. 92:e15–e16. 2007. View Article : Google Scholar : PubMed/NCBI
20	Haque M, Hou JS, Hisamichi K, Tamada K, Cusack CA, Abdelmalek M, Brown RE and Vonderheid EC: Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease: Review and speculations about pathogenesis. Clin Lymphoma Myeloma Leuk. 11:453–4561. 2011. View Article : Google Scholar : PubMed/NCBI
21	Semeraro M, Vacchelli E, Eggermont A, Galon J, Zitvogel L, Kroemer G and Galluzzi L: Trial Watch: Lenalidomide-based immunochemotherapy. Oncoimmunology. 2:e264942013. View Article : Google Scholar : PubMed/NCBI