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Article

Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma

  • Authors:
    • Zengjin Liu
    • Huamin Han
    • Xin He
    • Shouwei Li
    • Chenxing Wu
    • Chunjiang Yu
    • Shengdian Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P.R. China, Key Laboratory of Infection and Immunity, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, P.R. China
  • Pages: 1829-1834
    |
    Published online on: January 26, 2016
       https://doi.org/10.3892/ol.2016.4142
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Abstract

Glioma is known to induce local and systemic immunosuppression, which inhibits antitumor T cell responses. The galectin‑9‑Tim‑3‑pathway negatively regulates T cell pathways in the tumor immunosuppressive environment. The present study assessed the expression of Tim‑3 and galectin‑9 in glioma patients, and evaluated the association between the expression of Tim‑3 and galectin‑9 with clinical characteristics. The present study identified that Tim‑3 expression was significantly increased in peripheral blood T cells of glioma patients compared with those of healthy controls, and was additionally increased on tumor‑infiltrating T cells. The expression of Tim‑3 on tumor‑infiltrating T cells was associated with the World Health Organization (WHO) grade of glioma, but negatively correlated with the Karnofsky Performance Status score of the glioma patients. Immunohistochemical analysis revealed that the expression of galectin‑9 in tumor tissues was associated with Tim‑3 expression on tumor‑infiltrating T cells and the WHO grade of glioma. These findings suggest that the galectin‑9‑Tim‑3 pathway may be critical in the immunoevasion of glioma and may be a potent target for immunotherapy in glioma patients.
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1 

Liu Y, Shete S, Hosking F, Robertson L, Houlston R and Bondy M: Genetic advances in glioma: Susceptibility genes and networks. Curr Opin Genet Dev. 20:239–244. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Okada H, Kohanbash G, Zhu X, Kastenhuber ER, Hoji A, Ueda R and Fujita M: Immunotherapeutic approaches for glioma. Crit Rev Immunol. 29:1–42. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Flies DB, Sandler BJ, Sznol M and Chen L: Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy. Yale J Biol Med. 84:409–421. 2011.PubMed/NCBI

5 

Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 366:2443–2454. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK and Hafler DA: Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 203:1413–1418. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB and Kuchroo VK: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol. 6:1245–1252. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Ju Y, Hou N, Meng J, Wang X, Zhang X, Zhao D, Liu Y, Zhu F, Zhang L, Sun W, et al: T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J Hepatol. 52:322–329. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Lemke D, Pfenning PN, Sahm F, Klein AC, Kempf T, Warnken U, Schnölzer M, Tudoran R, Weller M, Platten M and Wick W: Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness. Clin Cancer Res. 18:105–117. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Wainwright DA, Chang AL, Dey M, Balyasnikova IV, Kim CK, Tobias A, Cheng Y, Kim JW, Qiao J, Zhang L, et al: Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors. Clin Cancer Res. 20:5290–5301. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

12 

De Groot CJ, Montagne L, Janssen I, Ravid R, Van Der Valk P and Veerhuis R: Isolation and characterization of adult microglial cells and oligodendrocytes derived from postmortem human brain tissue. Brain Res Brain Res Protoc. 5:85–94. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Olah M, Raj D, Brouwer N, De Haas AH, Eggen BJ, Den Dunnen WF, Biber KP and Boddeke HW: An optimized protocol for the acute isolation of human microglia from autopsy brain samples. Glia. 60:96–111. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, et al: A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. 12:395–402. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Mack PC, Redman MW, Chansky K, Williamson SK, Farneth NC, Lara PN Jr, Franklin WA, Le QT, Crowley JJ and Gandara DR: SWOG: Lower osteopontin plasma levels are associated with superior outcomes in advanced non-small-cell lung cancer patients receiving platinum-based chemotherapy: SWOG Study S0003. J Clin Oncol. 26:4771–4776. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Wang L, He S, Tu Y, Ji P, Zong J, Zhang J, Feng F, Zhao J, Gao G and Zhang Y: Downregulation of chromatin remodeling factor CHD5 is associated with a poor prognosis in human glioma. J Clin Neurosci. 20:958–963. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Ji Y, Wei Y, Wang J, Ao Q, Gong K and Zuo H: Decreased expression of microRNA-107 predicts poorer prognosis in glioma. Tumour Biol. 36:4461–4466. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, et al: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 415:536–541. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Asakura H, Kashio Y, Nakamura K, Seki M, Dai S, Shirato Y, Abedin MJ, Yoshida N, Nishi N, Imaizumi T, et al: Selective eosinophil adhesion to fibroblast via IFN-gamma-induced galectin-9. J Immunol. 169:5912–5918. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Park WS, Jung WK, Park SK, Heo KW, Kang MS, Choi YH, Kim GY, Park SG, Seo SK, Yea SS, et al: Expression of galectin-9 by IFN-γ stimulated human nasal polyp fibroblasts through MAPK, PI3K, and JAK/STAT signaling pathways. Biochem Biophys Res Commun. 411:259–264. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Ungerer C, Quade-Lyssy P, Radeke HH, Henschler R, Königs C, Köhl U, Seifried E and Schüttrumpf J: Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations. Stem Cells Dev. 23:755–766. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, et al: Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science. 318:1141–1143. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Rolle CE, Sengupta S and Lesniak MS: Mechanisms of immune evasion by gliomas. Adv Exp Med Biol. 746:53–76. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Anderson AC: Tim-3, a negative regulator of anti-tumor immunity. Curr Opin Immunol. 24:213–216. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Kuchroo V and Zarour HM: Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med. 207:2175–2186. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK and Anderson AC: Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med. 207:2187–2194. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Baitsch L, Baumgaertner P, Devêvre E, Raghav SK, Legat A, Barba L, Wieckowski S, Bouzourene H, Deplancke B, Romero P, et al: Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients. J Clin Invest. 121:2350–2360. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Calinescu AA, Kamran N, Baker G, Mineharu Y, Lowenstein PR and Castro MG: Overview of current immunotherapeutic strategies for glioma. Immunotherapy. 7:1073–1104. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Han H, He X, Li S, Wu C, Yu C and Wang S: Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma. Oncol Lett 11: 1829-1834, 2016.
APA
Liu, Z., Han, H., He, X., Li, S., Wu, C., Yu, C., & Wang, S. (2016). Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma. Oncology Letters, 11, 1829-1834. https://doi.org/10.3892/ol.2016.4142
MLA
Liu, Z., Han, H., He, X., Li, S., Wu, C., Yu, C., Wang, S."Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma". Oncology Letters 11.3 (2016): 1829-1834.
Chicago
Liu, Z., Han, H., He, X., Li, S., Wu, C., Yu, C., Wang, S."Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma". Oncology Letters 11, no. 3 (2016): 1829-1834. https://doi.org/10.3892/ol.2016.4142
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Han H, He X, Li S, Wu C, Yu C and Wang S: Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma. Oncol Lett 11: 1829-1834, 2016.
APA
Liu, Z., Han, H., He, X., Li, S., Wu, C., Yu, C., & Wang, S. (2016). Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma. Oncology Letters, 11, 1829-1834. https://doi.org/10.3892/ol.2016.4142
MLA
Liu, Z., Han, H., He, X., Li, S., Wu, C., Yu, C., Wang, S."Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma". Oncology Letters 11.3 (2016): 1829-1834.
Chicago
Liu, Z., Han, H., He, X., Li, S., Wu, C., Yu, C., Wang, S."Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma". Oncology Letters 11, no. 3 (2016): 1829-1834. https://doi.org/10.3892/ol.2016.4142
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