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Article

Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study

  • Authors:
    • Frédéric Selle
    • George Emile
    • Patricia Pautier
    • Irène Asmane
    • Daniele G. Soares
    • Ahmed Khalil
    • Jerome Alexandre
    • Catherine Lhommé
    • Isabelle Ray‑Coquard
    • Jean‑Pierre Lotz
    • François Goldwasser
    • Youssef Tazi
    • Pierre Heudel
    • Eric Pujade‑Lauraine
    • Sébastien Gouy
    • Olivier Tredan
    • Marie O. Barbaza
    • Nora Ady‑Vago
    • Coraline Dubot
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Alliance For Cancer Research (APREC), Tenon Hospital, Public Assistance Hospitals of Paris (AP‑HP), Paris 75020, France, Department of Medical Oncology, Cochin Hospital/Hotel Dieu, AP‑HP, Paris Descartes University (University of Paris V), Paris 75014, France, Department of Medical Oncology, Gustave Roussy, Villejuif 94805, France, Oncology Department, Centre Léon Bérard, Lyon 69008, France, Department of Statistics, Auxesia, Decines‑Charpieu 69150, France, Roche S.A.S., Boulogne‑Billancourt 92650, France
  • Pages: 1859-1865
    |
    Published online on: January 26, 2016
       https://doi.org/10.3892/ol.2016.4146
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Abstract

The poor outcome of patients with recurrent ovarian cancer constitutes a continuous challenge for decision‑making in clinical practice. In this setting, molecular targets have recently been identified, and novel compounds are now available. Bevacizumab has been introduced for the treatment of patients with ovarian cancer and is, to date, the most extensively investigated targeted therapy in this setting. However, potential toxicities are associated with the use of this monoclonal antibody. These toxicities have been reported in clinical trials, and can also be observed outside of trials. As limited data is currently available regarding the safety of bevacizumab treatment in daily clinical practice, the current retrospective study was designed to evaluate this. Data from 156 patients with recurrent ovarian cancer who had received bevacizumab treatment between January 2006 and June 2009 were retrospectively identified from the institutional records of five French centers. In contrast to clinical trials, the patients in the present study were not selected and had a heterogeneous profile according to their prior medical history, lines of treatment prior to bevacizumab introduction and number of relapses. The results first confirm the effect of heavy pretreatment on the occurrence of serious and fatal adverse events in clinical practice, as previously reported for clinical trials and for other retrospective cohort studies. Importantly, the data also demonstrates, for the first time, that medical history of hypertension is an independent predictive risk factor for the development of high‑grade hypertension during bevacizumab treatment. These results thus suggest that treating physicians must consider all risk factors for managing bevacizumab toxicity prior to its introduction. Such risk factors include the time of bevacizumab introduction, a patient's history of hypertension and a low incidence of pre-existing obstructive disease.
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Copy and paste a formatted citation
Spandidos Publications style
Selle F, Emile G, Pautier P, Asmane I, Soares DG, Khalil A, Alexandre J, Lhommé C, Ray‑Coquard I, Lotz JP, Lotz JP, et al: Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study. Oncol Lett 11: 1859-1865, 2016.
APA
Selle, F., Emile, G., Pautier, P., Asmane, I., Soares, D.G., Khalil, A. ... Dubot, C. (2016). Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study. Oncology Letters, 11, 1859-1865. https://doi.org/10.3892/ol.2016.4146
MLA
Selle, F., Emile, G., Pautier, P., Asmane, I., Soares, D. G., Khalil, A., Alexandre, J., Lhommé, C., Ray‑Coquard, I., Lotz, J., Goldwasser, F., Tazi, Y., Heudel, P., Pujade‑Lauraine, E., Gouy, S., Tredan, O., Barbaza, M. O., Ady‑Vago, N., Dubot, C."Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study". Oncology Letters 11.3 (2016): 1859-1865.
Chicago
Selle, F., Emile, G., Pautier, P., Asmane, I., Soares, D. G., Khalil, A., Alexandre, J., Lhommé, C., Ray‑Coquard, I., Lotz, J., Goldwasser, F., Tazi, Y., Heudel, P., Pujade‑Lauraine, E., Gouy, S., Tredan, O., Barbaza, M. O., Ady‑Vago, N., Dubot, C."Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study". Oncology Letters 11, no. 3 (2016): 1859-1865. https://doi.org/10.3892/ol.2016.4146
Copy and paste a formatted citation
x
Spandidos Publications style
Selle F, Emile G, Pautier P, Asmane I, Soares DG, Khalil A, Alexandre J, Lhommé C, Ray‑Coquard I, Lotz JP, Lotz JP, et al: Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study. Oncol Lett 11: 1859-1865, 2016.
APA
Selle, F., Emile, G., Pautier, P., Asmane, I., Soares, D.G., Khalil, A. ... Dubot, C. (2016). Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study. Oncology Letters, 11, 1859-1865. https://doi.org/10.3892/ol.2016.4146
MLA
Selle, F., Emile, G., Pautier, P., Asmane, I., Soares, D. G., Khalil, A., Alexandre, J., Lhommé, C., Ray‑Coquard, I., Lotz, J., Goldwasser, F., Tazi, Y., Heudel, P., Pujade‑Lauraine, E., Gouy, S., Tredan, O., Barbaza, M. O., Ady‑Vago, N., Dubot, C."Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study". Oncology Letters 11.3 (2016): 1859-1865.
Chicago
Selle, F., Emile, G., Pautier, P., Asmane, I., Soares, D. G., Khalil, A., Alexandre, J., Lhommé, C., Ray‑Coquard, I., Lotz, J., Goldwasser, F., Tazi, Y., Heudel, P., Pujade‑Lauraine, E., Gouy, S., Tredan, O., Barbaza, M. O., Ady‑Vago, N., Dubot, C."Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study". Oncology Letters 11, no. 3 (2016): 1859-1865. https://doi.org/10.3892/ol.2016.4146
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