Open Access

Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma

  • Authors:
    • Guangliang Qiang
    • Wei Huang
    • Chaoyang Liang
    • Rui Xu
    • Jue Yan
    • Yanyan Xu
    • Ye Wang
    • Jiping Da
    • Bin Shi
    • Yongqing Guo
    • Deruo Liu
  • View Affiliations

  • Published online on: January 27, 2016     https://doi.org/10.3892/ol.2016.4154
  • Pages: 1769-1777
  • Copyright: © Qiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the association between histopathological subtypes, epidermal growth factor receptor (EGFR) mutations and 18F‑fluorodeoxyglucose (FDG) uptake in patients with lung adenocarcinoma (ADC). The cases of 97 patients with lung ADC who underwent 18F‑FDG positron emission tomography‑computed tomography prior to surgical resection were retrospectively reviewed. The patients were stratified according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification, and graded using a histopathological scoring system. EGFR mutations were identified. Clinicopathological characteristics associated with EGFR mutation status were evaluated using univariate and multivariate analyses. EGFR mutation was identified in 45.4% of the patients and was associated with gender, smoking history, maximum standardized uptake value (SUVmax) and histopathological score. ADC patients with a low SUVmax were more likely to exhibit EGFR mutations compared with patients with a high SUVmax (P=0.018). Patients with a lower histopathological score possessed a significantly lower SUVmax compared with patients with a higher score (P<0.001). Furthermore, the histopathological score and smoking history of the patients were identified to be independent predictors for EGFR mutations, according to multivariate logistic regression analysis. In conclusion, SUVmax and EGFR mutations were associated with lung ADC patients stratified according to the IASLC/ATS/ERS classification. Overall, SUVmax has the potential to be a useful marker in stratifying pre‑operative patients with lung ADC and identifying EGFR mutations.
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March-2016
Volume 11 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qiang G, Huang W, Liang C, Xu R, Yan J, Xu Y, Wang Y, Da J, Shi B, Guo Y, Guo Y, et al: Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma. Oncol Lett 11: 1769-1777, 2016.
APA
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y. ... Liu, D. (2016). Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma. Oncology Letters, 11, 1769-1777. https://doi.org/10.3892/ol.2016.4154
MLA
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y., Wang, Y., Da, J., Shi, B., Guo, Y., Liu, D."Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma". Oncology Letters 11.3 (2016): 1769-1777.
Chicago
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y., Wang, Y., Da, J., Shi, B., Guo, Y., Liu, D."Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma". Oncology Letters 11, no. 3 (2016): 1769-1777. https://doi.org/10.3892/ol.2016.4154