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Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma

  • Authors:
    • Guangliang Qiang
    • Wei Huang
    • Chaoyang Liang
    • Rui Xu
    • Jue Yan
    • Yanyan Xu
    • Ye Wang
    • Jiping Da
    • Bin Shi
    • Yongqing Guo
    • Deruo Liu
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P.R. China, Department of Nuclear Medicine, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, Department of Radiology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, Department of Pathology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China
    Copyright: © Qiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1769-1777
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    Published online on: January 27, 2016
       https://doi.org/10.3892/ol.2016.4154
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Abstract

The aim of the present study was to investigate the association between histopathological subtypes, epidermal growth factor receptor (EGFR) mutations and 18F‑fluorodeoxyglucose (FDG) uptake in patients with lung adenocarcinoma (ADC). The cases of 97 patients with lung ADC who underwent 18F‑FDG positron emission tomography‑computed tomography prior to surgical resection were retrospectively reviewed. The patients were stratified according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification, and graded using a histopathological scoring system. EGFR mutations were identified. Clinicopathological characteristics associated with EGFR mutation status were evaluated using univariate and multivariate analyses. EGFR mutation was identified in 45.4% of the patients and was associated with gender, smoking history, maximum standardized uptake value (SUVmax) and histopathological score. ADC patients with a low SUVmax were more likely to exhibit EGFR mutations compared with patients with a high SUVmax (P=0.018). Patients with a lower histopathological score possessed a significantly lower SUVmax compared with patients with a higher score (P<0.001). Furthermore, the histopathological score and smoking history of the patients were identified to be independent predictors for EGFR mutations, according to multivariate logistic regression analysis. In conclusion, SUVmax and EGFR mutations were associated with lung ADC patients stratified according to the IASLC/ATS/ERS classification. Overall, SUVmax has the potential to be a useful marker in stratifying pre‑operative patients with lung ADC and identifying EGFR mutations.
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View References

1 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Youlden DR, Cramb SM and Baade PD: The International Epidemiology of Lung Cancer: Geographical distribution and secular trends. J Thorac Oncol. 3:819–831. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Kerr KM: Pulmonary adenocarcinomas: Classification and reporting. Histopathology. 54:12–27. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, et al: International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 6:244–285. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Yoshizawa A, Motoi N, Riely GJ, Sima CS, Gerald WL, Kris MG, Park BJ, Rusch VW and Travis WD: Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: Prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol. 24:653–664. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zugazagoitia J, Enguita AB, Nuñez JA, Iglesias L and Ponce S: The new IASLC/ATS/ERS lung adenocarcinoma classification from a clinical perspective: Current concepts and future prospects. J Thorac Dis. 6(Suppl 5): S526–S536. 2014.PubMed/NCBI

7 

Hung JJ, Jeng WJ, Chou TY, Hsu WH, Wu KJ, Huang BS and Wu YC: Prognostic value of the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society lung adenocarcinoma classification on death and recurrence in completely resected stage I lung adenocarcinoma. Ann Surg. 258:1079–1086. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Warth A, Muley T, Meister M, Stenzinger A, Thomas M, Schirmacher P, Schnabel PA, Budczies J, Hoffmann H and Weichert W: The novel histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stage-independent predictor of survival. J Clin Oncol. 30:1438–1446. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Song Z, Zhu H, Guo Z, Wu W, Sun W and Zhang Y: Prognostic value of the IASLC/ATS/ERS classification in stage I lung adenocarcinoma patients - based on a hospital study in China. Eur J Surg Oncol. 39:1262–1268. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Paesmans M, Berghmans T, Dusart M, et al: European Lung Cancer Working Party, and on behalf of the IASLC Lung Cancer Staging Project: Primary tumor standardized uptake value measured on fluorodeoxyglucose positron emission tomography is of prognostic value for survival in non-small cell lung cancer: Update of a systematic review and meta-analysis by the European Lung Cancer Working Party for the International Association for the Study of Lung Cancer Staging Project. J Thorac Oncol. 5:612–619. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Chiu CH, Yeh YC, Lin KH, Wu YC, Lee YC, Chou TY and Tsai CM: Histological subtypes of lung adenocarcinoma have differential 18F-fluorodeoxyglucose uptakes on the positron emission tomography/computed tomography scan. J Thorac Oncol. 6:1697–1703. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Yoshizawa A, Sumiyoshi S, Sonobe M, et al: Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: Analysis of 440 Japanese patients. J Thorac Oncol. 8:52–61. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Yanagawa N, Shiono S, Abiko M, et al: The correlation of the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification with prognosis and EGFR mutation in lung adenocarcinoma. Ann Thorac Surg. 98:453–458. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Travis WD, Brambilla E, Müller-Hermelink HK and Harris CC: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (Lyon). IARC Press. 2004.

15 

Sica G, Yoshizawa A, Sima CS, Azzoli CG, Downey RJ, Rusch VW, Travis WD and Moreira AL: A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors. Am J Surg Pathol. 34:1155–1162. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual (7th). New York, NY: Springer-Verlag. 253–270. 2010.

17 

Shaozhang Z, Ming Z, Haiyan P, Aiping Z, Qitao Y and Xiangqun S: Comparison of ARMS and direct sequencing for detection of EGFR mutation and prediction of EGFR-TKI efficacy between surgery and biopsy tumor tissues in NSCLC patients. Med Oncol. 31:9262014. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C, Majem M, Lopez-Vivanco G, Isla D, Provencio M, et al: Spanish Lung Cancer Group: Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 361:958–967. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, et al: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 97:339–346. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Toyooka S, Matsuo K, Shigematsu H, Kosaka T, Tokumo M, Yatabe Y, Ichihara S, Inukai M, Suehisa H, Soh J, et al: The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Clin Cancer Res. 13:5763–5768. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Hsiao SH, Lin SE, Chou YT, Wang JL, Chung CL, Yu MC, Fang CL, Lee HL, Chiang LL, Liu HE and Wu CW: Histological subtype and smoking status, but not gender, are associated with epidermal growth factor receptor mutations in non-small-cell lung cancer. Mol Clin Oncol. 2:252–258. 2014.PubMed/NCBI

23 

Shim HS, Lee H, Park EJ and Kim SH: Histopathologic characteristics of lung adenocarcinomas with epidermal growth factor receptor mutations in the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society lung adenocarcinoma classification. Arch Pathol Lab Med. 135:1329–1334. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Sun PL, Seol H, Lee HJ, Yoo SB, Kim H, Xu X, Jheon S, Lee CT, Lee JS and Chung JH: High incidence of EGFR mutations in Korean men smokers with no intratumoral heterogeneity of lung adenocarcinomas: Correlation with histologic subtypes, EGFR/TTF-1 expressions, and clinical features. J Thorac Oncol. 7:323–330. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Y, Sun Y, Pan Y, et al: Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis. Clin Cancer Res. 18:1947–1953. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Russell PA, Barnett SA, Walkiewicz M, Wainer Z, Conron M, Wright GM, Gooi J, Knight S, Wynne R, Liew D and John T: Correlation of mutation status and survival with predominant histologic subtype according to the new IASLC/ATS/ERS lung adenocarcinoma classification in stage III (N2) patients. J Thorac Oncol. 8:461–468. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Song Z, Zhu H, Guo Z, Wu W, Sun W and Zhang Y: Correlation of EGFR mutation and predominant histologic subtype according to the new lung adenocarcinoma classification in Chinese patients. Med Oncol. 30:6452013. View Article : Google Scholar : PubMed/NCBI

28 

Tsuta K, Kawago M, Inoue E, et al: The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. Lung Cancer. 81:371–376. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Villa C, Cagle PT, Johnson M, et al: Correlation of EGFR mutation status with predominant histologic subtype of adenocarcinoma according to the new lung adenocarcinoma classification of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society. Arch Pathol Lab Med. 138:1353–1357. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Sun Y, Yu X, Shi X, Hong W, Zhao J and Shi L: Correlation of survival and EGFR mutation with predominant histologic subtype according to the new lung adenocarcinoma classification in stage IB patients. World J Surg Oncol. 12:1482014. View Article : Google Scholar : PubMed/NCBI

31 

Kim HJ, Choi EY, Jin HJ and Shin KC: Relationship between EGFR mutations and clinicopathological features of lung adenocarcinomas diagnosed via small biopsies. Anticancer Res. 34:3189–3195. 2014.PubMed/NCBI

32 

Tokumo M, Toyooka S, Kiura K, et al: The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers. Clin Cancer Res. 11:1167–1173. 2005.PubMed/NCBI

33 

Pham D, Kris MG, Riely GJ, et al: Use of cigarette-smoking history to estimate the likelihood of mutations in epidermal growth factor receptor gene exons 19 and 21 in lung adenocarcinomas. J Clin Oncol. 24:1700–1704. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Otto WR: Lung epithelial stem cells. J Pathol. 197:527–535. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Okudela K, Suzuki M, Kageyama S, et al: PIK3CA mutation and amplification in human lung cancer. Pathol Int. 57:664–671. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Rekhtman N, Ang DC, Riely GJ, Ladanyi M and Moreira AL: KRAS mutations are associated with solid growth pattern and tumor-infiltrating leukocytes in lung adenocarcinoma. Mod Pathol. 26:1307–1319. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Suzuki M, Shigematsu H, Iizasa T, et al: Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer. Cancer. 106:2200–2207. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Vesselle H, Salskov A, Turcotte E, Wiens L, Schmidt R, Jordan CD, Vallières E and Wood DE: Relationship between non-small cell lung cancer FDG uptake at PET, tumor histology, and Ki-67 proliferation index. J Thorac Oncol. 3:971–978. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Kadota K, Colovos C, Suzuki K, Rizk NP, Dunphy MP, Zabor EC, Sima CS, Yoshizawa A, Travis WD, Rusch VW and Adusumilli PS: FDG-PET SUVmax combined with IASLC/ATS/ERS histologic classification improves the prognostic stratification of patients with stage I lung adenocarcinoma. Ann Surg Oncol. 19:3598–3605. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Higashi K, Ueda Y, Yagishita M, Arisaka Y, Sakurai A, Oguchi M, Seki H, Nambu Y, Tonami H and Yamamoto I: FDG PET measurement of the proliferative potential of non-small cell lung cancer. J Nucl Med. 41:85–92. 2000.PubMed/NCBI

41 

Hasegawa M, Sone S, Takashima S, Li F, Yang ZG, Maruyama Y and Watanabe T: Growth rate of small lung cancers detected on mass CT screening. Br J Radiol. 73:1252–1259. 2000. View Article : Google Scholar : PubMed/NCBI

42 

de Geus-Oei LF, van Krieken JH, Aliredjo RP, Krabbe PF, Frielink C, Verhagen AF, Boerman OC and Oyen WJ: Biological correlates of FDG uptake in non-small cell lung cancer. Lung Cancer. 55:79–87. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Li M, Sun Y, Liu Y, Han A, Zhao S, Ma L, Zheng J and Yu J: Relationship between primary lesion FDG uptake and clinical stage at PET-CT for non-small cell lung cancer patients: An observation. Lung Cancer. 68:394–397. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Usuda K, Sagawa M, Motono N, Ueno M, Tanaka M, Machida Y, Matoba M, Taniguchi M, Tonami H, Ueda Y and Sakuma T: Relationships between EGFR mutation status of lung cancer and preoperative factors - are they predictive? Asian Pac J Cancer Prev. 15:657–662. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Na II, Byun BH, Kim KM, Cheon GJ, Choe H, Koh JS, Lee DY, Ryoo BY, Baek H, Lim SM, et al: 18F-FDG uptake and EGFR mutations in patients with non-small cell lung cancer: A single-institution retrospective analysis. Lung Cancer. 67:76–80. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Mak RH, Digumarthy SR, Muzikansky A, Engelman JA, Shepard JA, Choi NC and Sequist LV: Role of 18F-fluorodeoxyglucose positron emission tomography in predicting epidermal growth factor receptor mutations in non-small cell lung cancer. Oncologist. 16:319–326. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Usuda K, Sagawa M, Aikawa H, Ueno M, Tanaka M, Machida Y, Zhao XT, Ueda Y, Higashi K and Sakuma T: Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission tomography in lung cancer. Gen Thorac Cardiovasc Surg. 58:405–410. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Mamede M, Higashi T, Kitaichi M, Ishizu K, Ishimori T, Nakamoto Y, Yanagihara K, Li M, Tanaka F, Wada H, et al: [18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung. Neoplasia. 7:369–379. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Nguyen XC, Lee WW, Chung JH, et al: FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: Correlations and prognostic values. Eur J Radiol. 62:214–219. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Yun J, Rago C, Cheong I, et al: Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science. 325:1555–1559. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Sasaki H, Shitara M, Yokota K, Hikosaka Y, Moriyama S, Yano M and Fujii Y: Overexpression of GLUT1 correlates with Kras mutations in lung carcinomas. Mol Med Rep. 5:599–602. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qiang G, Huang W, Liang C, Xu R, Yan J, Xu Y, Wang Y, Da J, Shi B, Guo Y, Guo Y, et al: Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma. Oncol Lett 11: 1769-1777, 2016.
APA
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y. ... Liu, D. (2016). Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma. Oncology Letters, 11, 1769-1777. https://doi.org/10.3892/ol.2016.4154
MLA
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y., Wang, Y., Da, J., Shi, B., Guo, Y., Liu, D."Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma". Oncology Letters 11.3 (2016): 1769-1777.
Chicago
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y., Wang, Y., Da, J., Shi, B., Guo, Y., Liu, D."Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma". Oncology Letters 11, no. 3 (2016): 1769-1777. https://doi.org/10.3892/ol.2016.4154
Copy and paste a formatted citation
x
Spandidos Publications style
Qiang G, Huang W, Liang C, Xu R, Yan J, Xu Y, Wang Y, Da J, Shi B, Guo Y, Guo Y, et al: Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma. Oncol Lett 11: 1769-1777, 2016.
APA
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y. ... Liu, D. (2016). Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma. Oncology Letters, 11, 1769-1777. https://doi.org/10.3892/ol.2016.4154
MLA
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y., Wang, Y., Da, J., Shi, B., Guo, Y., Liu, D."Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma". Oncology Letters 11.3 (2016): 1769-1777.
Chicago
Qiang, G., Huang, W., Liang, C., Xu, R., Yan, J., Xu, Y., Wang, Y., Da, J., Shi, B., Guo, Y., Liu, D."Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma". Oncology Letters 11, no. 3 (2016): 1769-1777. https://doi.org/10.3892/ol.2016.4154
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