Open Access

20(S)‑Protopanaxadiol saponins inhibit SKOV3 cell migration

  • Authors:
    • Bin Li
    • Daomei Chen
    • Wanyi Li
    • Dan Xiao
  • View Affiliations

  • Published online on: January 27, 2016     https://doi.org/10.3892/ol.2016.4155
  • Pages: 1693-1698
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

While the anti‑tumor actions of ginsenosides from Panax notoginseng are well‑studied, the anti‑proliferative activity of 20(S)‑protopanaxadiol saponins (PDS) in Sanchi ginseng on human ovarian cancer has not been reported, nor has its effect on migration of SKOV3 cells been investigated. In the present study, a wound‑healing assay indicated that PDS inhibited the migration of SKOV3 cells, and a Matrigel™ tube formation assay demonstrated the presence of inhibitory tube‑structures following treatment with PDS. To date, there are no previous reports on the regulation of osteopontin (OPN), a glycophosphoprotein cytokine frequently expressed in ovarian carcinoma effusions by PDS. A reduction in the expression of OPN following PDS‑treatment was observed using immunohistochemical and western blot experiments. These results suggest that PDS may be useful in the search for a potential ovarian cancer treatment.
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March-2016
Volume 11 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li B, Chen D, Li W and Xiao D: 20(S)‑Protopanaxadiol saponins inhibit SKOV3 cell migration. Oncol Lett 11: 1693-1698, 2016
APA
Li, B., Chen, D., Li, W., & Xiao, D. (2016). 20(S)‑Protopanaxadiol saponins inhibit SKOV3 cell migration. Oncology Letters, 11, 1693-1698. https://doi.org/10.3892/ol.2016.4155
MLA
Li, B., Chen, D., Li, W., Xiao, D."20(S)‑Protopanaxadiol saponins inhibit SKOV3 cell migration". Oncology Letters 11.3 (2016): 1693-1698.
Chicago
Li, B., Chen, D., Li, W., Xiao, D."20(S)‑Protopanaxadiol saponins inhibit SKOV3 cell migration". Oncology Letters 11, no. 3 (2016): 1693-1698. https://doi.org/10.3892/ol.2016.4155