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Article

A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia

  • Authors:
    • Moneeb A.K. Othman
    • Beata Grygalewicz
    • Barbara Pienkowska‑Grela
    • Jolanta Rygier
    • Anna Ejduk
    • Martina Rincic
    • Joana B. Melo
    • Isabel M. Carreira
    • Britta Meyer
    • Thomas Liehr
  • View Affiliations / Copyright

    Affiliations: Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena D‑07740, Germany, Cytogenetic Laboratory, Maria Sklodowska‑Curie Memorial Cancer Centre and Institute, Warsaw 02‑781, Poland, Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw 02‑776, Poland, Laboratory of Cytogenetics and Genomics, Faculty of Medicine, University of Coimbra, Coimbra 3001‑401, Portugal, ZytoVision GmbH, Bremerhaven D‑27572, Germany
  • Pages: 2117-2122
    |
    Published online on: January 29, 2016
       https://doi.org/10.3892/ol.2016.4169
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Abstract

Acquired copy number changes are common in acute leukemia. They are reported as recurrent amplifications or deletions (del), and may be indicative of involvement of oncogenes or tumor suppressor genes in acquired disease, as well as serving as potential biomarkers for prognosis or as targets for molecular therapy. The present study reported a gain of copy number of 14q13 to 14q32, leading to immunoglobulin heavy chain locus splitting in a young adult female. To the best of our knowledge, this rearrangement has not been previously reported in B‑cell acute lymphoblastic leukemia (ALL). Low resolution banding cytogenetics performed at the time of diagnosis revealed a normal karyotype. However, retrospective application of fluorescence in situ hybridization (FISH) banding and locus‑specific FISH probes, as well as multiplex ligation‑dependent probe amplification and high resolution array‑comparative genomic hybridization, revealed previously hidden aberrations. Overall, a karyotype of 46,​XX,​del(9)​(p21.3​p21.3),derivative(14)​(pter‑>​q32.33::​q32.33‑>​q13​::q32.33‑>​qter) was determined. The patient was treated according to the Polish Adult Leukemia Group protocol and achieved complete remission. The results of the present study indicate that a favorable prognosis is associated with these aberrations when the aforementioned treatment is administered.
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Copy and paste a formatted citation
Spandidos Publications style
Othman MA, Grygalewicz B, Pienkowska‑Grela B, Rygier J, Ejduk A, Rincic M, Melo JB, Carreira IM, Meyer B, Liehr T, Liehr T, et al: A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia. Oncol Lett 11: 2117-2122, 2016.
APA
Othman, M.A., Grygalewicz, B., Pienkowska‑Grela, B., Rygier, J., Ejduk, A., Rincic, M. ... Liehr, T. (2016). A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia. Oncology Letters, 11, 2117-2122. https://doi.org/10.3892/ol.2016.4169
MLA
Othman, M. A., Grygalewicz, B., Pienkowska‑Grela, B., Rygier, J., Ejduk, A., Rincic, M., Melo, J. B., Carreira, I. M., Meyer, B., Liehr, T."A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia". Oncology Letters 11.3 (2016): 2117-2122.
Chicago
Othman, M. A., Grygalewicz, B., Pienkowska‑Grela, B., Rygier, J., Ejduk, A., Rincic, M., Melo, J. B., Carreira, I. M., Meyer, B., Liehr, T."A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia". Oncology Letters 11, no. 3 (2016): 2117-2122. https://doi.org/10.3892/ol.2016.4169
Copy and paste a formatted citation
x
Spandidos Publications style
Othman MA, Grygalewicz B, Pienkowska‑Grela B, Rygier J, Ejduk A, Rincic M, Melo JB, Carreira IM, Meyer B, Liehr T, Liehr T, et al: A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia. Oncol Lett 11: 2117-2122, 2016.
APA
Othman, M.A., Grygalewicz, B., Pienkowska‑Grela, B., Rygier, J., Ejduk, A., Rincic, M. ... Liehr, T. (2016). A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia. Oncology Letters, 11, 2117-2122. https://doi.org/10.3892/ol.2016.4169
MLA
Othman, M. A., Grygalewicz, B., Pienkowska‑Grela, B., Rygier, J., Ejduk, A., Rincic, M., Melo, J. B., Carreira, I. M., Meyer, B., Liehr, T."A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia". Oncology Letters 11.3 (2016): 2117-2122.
Chicago
Othman, M. A., Grygalewicz, B., Pienkowska‑Grela, B., Rygier, J., Ejduk, A., Rincic, M., Melo, J. B., Carreira, I. M., Meyer, B., Liehr, T."A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B‑cell acute lymphoblastic leukemia". Oncology Letters 11, no. 3 (2016): 2117-2122. https://doi.org/10.3892/ol.2016.4169
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