Curative effect of the recent photofrin photodynamic adjuvant treatment on young patients with advanced colorectal cancer

Sun,Bo; Li,Wei; Liu,Ning

doi:10.3892/ol.2016.4179

Curative effect of the recent photofrin photodynamic adjuvant treatment on young patients with advanced colorectal cancer

Authors:
- Bo Sun
- Wei Li
- Ning Liu
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Affiliations: Department of General Surgery, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221002, P.R. China, Department of Emergency Surgery, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221002, P.R. China
Published online on: February 2, 2016 https://doi.org/10.3892/ol.2016.4179
Pages: 2071-2074
Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Advanced colorectal cancer has a high mortality rate and conventional treatments have poor therapeutic effects. The aim of the present study was to analyze the recent curative effect and adverse reaction of photofrin photodynamic adjuvant treatment on young patients with advanced colorectal cancer. A total of 23 patients with advanced colorectal cancer who had accepted semiconductor laser photodynamic adjuvant treatment were selected as the observation group. In addition, 30 patients who had accepted concurrent radiotherapy and chemotherapy during the same period served as the control group. The observation group received photofrin (2 mg/kg) intravenously in 100 ml of 5% glucose, followed by the introduction of the endoscopic optical fiber to deliver laser radiation with an intensity of 630 nm wavelength pulse power. After 2 days, necrotic tissues were removed and irradiation of the original or new tumor lesions was performed and necrotic tissues were removed. The total effective rate and survival time was higher and the length of hospital stay was shorter in the observation group in comparison with the control group. The differences were statistically significant (P<0.05). The number of patients in the control and observation groups with symptoms of hematochezia, change in bowel habit, intestinal stimulation and incomplete intestinal obstruction were reduced. Additionally, the reduced ratio of the observation group was significantly increased in comparison with the control group (P<0.05). The adverse reaction rate of the observation group was lower than that of the control group and this difference was also statistically significant (P<0.05). In conclusion, use of photodynamic treatment for young patients with advanced colorectal cancer can effectively improve the clinical symptoms and reduce complications.

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