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Article Open Access

Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis

  • Authors:
    • Xue Sun
    • Ru Li
    • Botao Zhang
    • Yuejie Yang
    • Zhifei Cui
  • View Affiliations / Copyright

    Affiliations: Department of Medical Ultrasonics, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China, Department of Medical Ultrasonics, The Third Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China, Department of Medical Ultrasonics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2096-2100
    |
    Published online on: February 2, 2016
       https://doi.org/10.3892/ol.2016.4180
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Abstract

Liver cancer is a malignancy of the digestive system and has a high morbidity and mortality rate. Local intervention has become a viable option in identifying liver treatment. The aim of the present study was to analyze the clinical effects of treating liver cancer in middle and advanced stages using ultrasound‑guided percutaneous ethanol injection (PEI) in tumors combined with radiofrequency ablation (RFA). A total of 100 patients with stage III-IV liver cancers were selected to participate in the study. Patients were divided into groups. In group A, treatment was initiated with PEI and after 1‑2 weeks RFA was applied while in group B treatment was initiated with RFA and after 1‑2 weeks PEI was applied. Patients in group C received PEI and RFA simultaneously. The clinical effects in the 3 groups were compared after 6‑month follow ups. The volume of tumor ablation necrosis in group A was significantly greater than that in the groups B and C, while the size was significantly smaller compared to groups B and C after ablation. For group A, the complete ablation rate was significantly higher than that in groups B and C, and the differences were statistically significant (P<0.05). Liver damage indices, including raising levels of glutamic‑pyruvic transaminase and total bilirubin, were significantly decreased in group A (P<0.05). The survival rate in group A was also significantly higher than in groups B and C (P<0.05). In conclusion, for patients with liver cancer in middle and advanced stages, the treatment method using PEI followed by RFA was more beneficial in terms of improving the tumor ablation rate, alleviating liver damages and increasing survival rates.
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Copy and paste a formatted citation
Spandidos Publications style
Sun X, Li R, Zhang B, Yang Y and Cui Z: Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis. Oncol Lett 11: 2096-2100, 2016.
APA
Sun, X., Li, R., Zhang, B., Yang, Y., & Cui, Z. (2016). Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis. Oncology Letters, 11, 2096-2100. https://doi.org/10.3892/ol.2016.4180
MLA
Sun, X., Li, R., Zhang, B., Yang, Y., Cui, Z."Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis". Oncology Letters 11.3 (2016): 2096-2100.
Chicago
Sun, X., Li, R., Zhang, B., Yang, Y., Cui, Z."Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis". Oncology Letters 11, no. 3 (2016): 2096-2100. https://doi.org/10.3892/ol.2016.4180
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X, Li R, Zhang B, Yang Y and Cui Z: Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis. Oncol Lett 11: 2096-2100, 2016.
APA
Sun, X., Li, R., Zhang, B., Yang, Y., & Cui, Z. (2016). Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis. Oncology Letters, 11, 2096-2100. https://doi.org/10.3892/ol.2016.4180
MLA
Sun, X., Li, R., Zhang, B., Yang, Y., Cui, Z."Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis". Oncology Letters 11.3 (2016): 2096-2100.
Chicago
Sun, X., Li, R., Zhang, B., Yang, Y., Cui, Z."Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis". Oncology Letters 11, no. 3 (2016): 2096-2100. https://doi.org/10.3892/ol.2016.4180
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