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Article

Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps

  • Authors:
    • Andrea Ciavattini
    • Jacopo Di Giuseppe
    • Nicolò Clemente
    • Lorenzo Moriconi
    • Giovanni Delli Carpini
    • Nina Montik
    • Laura Mazzanti
  • View Affiliations / Copyright

    Affiliations: Gynecological Section, Women's Health Sciences Department, Polytechnic University of Marche, Ancona I‑60123, Italy, Biochemistry Section, Department of Clinical Sciences, Polytechnic University of Marche, Ancona I‑60123, Italy
  • Pages: 2278-2282
    |
    Published online on: February 4, 2016
       https://doi.org/10.3892/ol.2016.4186
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Abstract

The aim of the present study was to determine the association between the thickness of preperitoneal fat (PFT), utilized as an indicator of visceral fat deposition, and the risk of premalignant and malignant changes of endometrial polyps (EPs) in overweight and obese women. Overweight and obese women who had undergone diagnostic outpatient hysteroscopy and subsequent endometrial polypectomy between January 2010 and May 2013 were analyzed. Each patient underwent a transabdominal ultrasound for the purpose of measuring the thickness of preperitoneal fat. A total of 146 overweight or obese women were analyzed. The overall incidence of malignant or premalignant lesions was 8.2%. Notably, 5 patients (3.4%) received a histopathological diagnosis of complex hyperplasia with atypia, while polyps harboring carcinoma were diagnosed in 7 cases (4.8%). A significantly increased PFT was observed in women exhibiting preneoplastic and neoplastic lesions, compared with women with benign EPs (mean ± SD, 23.2±3.7 vs. 15.9±8.3; P<0.01). Patient age of >60 years was significantly associated with malignant progression of EPs, while body mass index, menopausal status, arterial hypertension, diabetes, abnormal uterine bleeding, hormone replacement therapy and tamoxifen treatment demonstrated no significant association with the development of preneoplastic and neoplastic lesions of the endometrium. In a multivariate analysis, only PFT maintained a significant correlation with the diagnosis of preneoplastic and neoplastic lesions on EPs (odds ratio, 1.14; 95% confidence interval, 1.04‑1.26). Ultrasound evaluation of PFT in overweight and obese women may be useful for the identification of a particularly high‑risk subgroup of women. Therefore, regardless of symptoms or additional clinical variables, these particularly high‑risk women require appropriate counseling and prompt surgical removal of EPs.
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Copy and paste a formatted citation
Spandidos Publications style
Ciavattini A, Di Giuseppe J, Clemente N, Moriconi L, Delli Carpini G, Montik N and Mazzanti L: Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps. Oncol Lett 11: 2278-2282, 2016.
APA
Ciavattini, A., Di Giuseppe, J., Clemente, N., Moriconi, L., Delli Carpini, G., Montik, N., & Mazzanti, L. (2016). Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps. Oncology Letters, 11, 2278-2282. https://doi.org/10.3892/ol.2016.4186
MLA
Ciavattini, A., Di Giuseppe, J., Clemente, N., Moriconi, L., Delli Carpini, G., Montik, N., Mazzanti, L."Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps". Oncology Letters 11.3 (2016): 2278-2282.
Chicago
Ciavattini, A., Di Giuseppe, J., Clemente, N., Moriconi, L., Delli Carpini, G., Montik, N., Mazzanti, L."Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps". Oncology Letters 11, no. 3 (2016): 2278-2282. https://doi.org/10.3892/ol.2016.4186
Copy and paste a formatted citation
x
Spandidos Publications style
Ciavattini A, Di Giuseppe J, Clemente N, Moriconi L, Delli Carpini G, Montik N and Mazzanti L: Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps. Oncol Lett 11: 2278-2282, 2016.
APA
Ciavattini, A., Di Giuseppe, J., Clemente, N., Moriconi, L., Delli Carpini, G., Montik, N., & Mazzanti, L. (2016). Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps. Oncology Letters, 11, 2278-2282. https://doi.org/10.3892/ol.2016.4186
MLA
Ciavattini, A., Di Giuseppe, J., Clemente, N., Moriconi, L., Delli Carpini, G., Montik, N., Mazzanti, L."Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps". Oncology Letters 11.3 (2016): 2278-2282.
Chicago
Ciavattini, A., Di Giuseppe, J., Clemente, N., Moriconi, L., Delli Carpini, G., Montik, N., Mazzanti, L."Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps". Oncology Letters 11, no. 3 (2016): 2278-2282. https://doi.org/10.3892/ol.2016.4186
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