18F‑fluoroethyl‑L‑tyrosine positron emission tomography for the differential diagnosis of tumefactive multiple sclerosis versus glioma: A case report

Kebir,Sied; Gaertner,Florian C.; Mueller,Marcus; Nelles,Michael; Simon,Matthias; Schäfer,Niklas; Stuplich,Moritz; Schaub,Christina; Niessen,Michael; Mack,Frederic; Bundschuh,Ralph; Greschus,Susanne; Essler,Markus; Glas,Martin; Herrlinger,Ulrich

doi:10.3892/ol.2016.4189

March-2016 Volume 11 Issue 3

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March-2016 Volume 11 Issue 3

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Case Report

18F‑fluoroethyl‑L‑tyrosine positron emission tomography for the differential diagnosis of tumefactive multiple sclerosis versus glioma: A case report

Authors:
- Sied Kebir
- Florian C. Gaertner
- Marcus Mueller
- Michael Nelles
- Matthias Simon
- Niklas Schäfer
- Moritz Stuplich
- Christina Schaub
- Michael Niessen
- Frederic Mack
- Ralph Bundschuh
- Susanne Greschus
- Markus Essler
- Martin Glas
- Ulrich Herrlinger
View Affiliations / Copyright

Affiliations: Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn 53127, Germany, Department of Nuclear Medicine, University of Bonn Medical Center, Bonn 53127, Germany, Department of Radiology, University of Bonn Medical Center, Bonn 53127, Germany, Department of Neurosurgery, University of Bonn Medical Center, Bonn 53127, Germany, Stem Cell Pathologies Group, Institute of Reconstructive Neurobiology, University of Bonn Medical Center, Bonn 53127, Germany
Pages: 2195-2198
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Published online on: February 4, 2016

https://doi.org/10.3892/ol.2016.4189
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Abstract

Large demyelinating inflammatory central nervous system (CNS) lesions may present with contrast enhancement on magnetic resonance imaging and may mimic CNS tumors such as glioma. In ambiguous cases, new diagnostic tools that may be helpful for distinguishing between demyelinating inflammatory and neoplastic CNS lesions are required. The current study presents the case of a patient with a large contrast‑enhanced frontal brain lesion, who was initially diagnosed with tumefactive multiple sclerosis. Following the progression of the brain lesion, an 18F‑fluoroethyl‑L‑tyrosine positron emission tomography (18F‑FET PET) was performed, revealing markedly elevated static 18F‑FET uptake parameters along with time activity‑curves consistent with glioma. Subsequently, a biopsy was undertaken, which confirmed the presence of anaplastic oligoastrocytoma. This case illustrates that 18F‑FET PET may provide useful diagnostic information in cases where distinction between neoplastic and demyelinating inflammatory CNS lesions is challenging. However, further systematic and prospective analyses are warranted to explore the value of this method in this setting.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

18F‑fluoroethyl‑L‑tyrosine positron emission tomography for the differential diagnosis of tumefactive multiple sclerosis versus glioma: A case report

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Abstract

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