Open Access

Expression of cluster of differentiation 74 in gallbladder carcinoma and the correlation with epithelial growth factor receptor levels

  • Authors:
    • Peng Wang
    • Qiao Shi
    • Teng Zuo
    • Xiaobo He
    • Jia Yu
    • Weixing Wang
  • View Affiliations

  • Published online on: February 8, 2016     https://doi.org/10.3892/ol.2016.4191
  • Pages: 2061-2066
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cluster of differentiation 74 (CD74), a transmembrane glycoprotein, has been previously reported to be important in the pathogenesis of several cancers, including hematological malignancies and solid tumors. The present study analyzed the significance of CD74 in gallbladder carcinomas (GBCs) and indicated the correlation of CD74 expression with epithelial growth factor receptor levels. Immunohistochemistry (IHC) was used to examine the expression of CD74 in GBC and normal gallbladder tissues, and western blotting was used to investigate whether CD74 expression varied in well‑, moderately‑ and poorly‑differentiated tumors. The correlation between the expression of CD74 and epithelial growth factor receptor levels was studied using the Spearman's rank correlation coefficient. The results of the IHC analysis revealed that CD74 was not expressed in the normal gallbladder tissues, and the mean integrated optical density value of CD74 in the poorly‑differentiated tissues was increased compared with that in the well‑ and moderately‑differentiated tissues. The results of the western blotting were consistent with the results of the IHC. The expression of CD74 was positively correlated with epithelial growth factor receptor levels (r=0.607; P<0.05). These results indicate that CD74 may be important in the progression of GBC.
View Figures
View References

Related Articles

Journal Cover

March-2016
Volume 11 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang P, Shi Q, Zuo T, He X, Yu J and Wang W: Expression of cluster of differentiation 74 in gallbladder carcinoma and the correlation with epithelial growth factor receptor levels. Oncol Lett 11: 2061-2066, 2016
APA
Wang, P., Shi, Q., Zuo, T., He, X., Yu, J., & Wang, W. (2016). Expression of cluster of differentiation 74 in gallbladder carcinoma and the correlation with epithelial growth factor receptor levels. Oncology Letters, 11, 2061-2066. https://doi.org/10.3892/ol.2016.4191
MLA
Wang, P., Shi, Q., Zuo, T., He, X., Yu, J., Wang, W."Expression of cluster of differentiation 74 in gallbladder carcinoma and the correlation with epithelial growth factor receptor levels". Oncology Letters 11.3 (2016): 2061-2066.
Chicago
Wang, P., Shi, Q., Zuo, T., He, X., Yu, J., Wang, W."Expression of cluster of differentiation 74 in gallbladder carcinoma and the correlation with epithelial growth factor receptor levels". Oncology Letters 11, no. 3 (2016): 2061-2066. https://doi.org/10.3892/ol.2016.4191