Epithelial membrane protein 1 expression in ovarian serous tumors

Demirag,Guzin  Gonullu; Kefeli,Mehmet; Kemal,Yasemin; Yucel,Idris

doi:10.3892/ol.2016.4202

March-2016 Volume 11 Issue 3

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March-2016 Volume 11 Issue 3

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Article

Epithelial membrane protein 1 expression in ovarian serous tumors

Authors:
- Guzin Gonullu Demirag
- Mehmet Kefeli
- Yasemin Kemal
- Idris Yucel
View Affiliations / Copyright

Affiliations: Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayis University, Samsun 53139, Turkey, Department of Pathology, Faculty of Medicine, Ondokuz Mayis University, Samsun 53139, Turkey
Pages: 2140-2144
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Published online on: February 8, 2016

https://doi.org/10.3892/ol.2016.4202
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Abstract

The present study aimed to analyze the clinical significance of epithelial membrane protein 1 (EMP1) expression in ovarian serous tumors. A total of 84 cases of ovarian serous tumor (50 patients with malignant ovarian serous tumors and 34 patients with borderline and benign serous tumors) were retrospectively analyzed. Differences in the expression levels of EMP1 between the malignant and non‑malignant tumor groups were evaluated by immunohistochemical staining. In addition, the association between EMP1 expression and prognostic factors in malignant ovarian serous tumors was investigated. The expression levels of EMP1 were significantly reduced in all the 50 malignant ovarian serous tumors, compared with the 34 non‑malignant ovarian serous tumors (P<0.000). Reduced expression of EMP1 was correlated with high grade (P=0.009) and stage (P<0.000) of malignant tumors. EMP1 expression was not observed to be correlated with any other investigated parameters, including surgery, type of operation and chemotherapy response (P>0.005). These results indicated that EMP1 may have a significant role as a negative regulator in ovarian serous tumors, and reduced EMP1 expression in serous tumors may be associated with increased disease severity.

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