Epithelial membrane protein 1 expression in ovarian serous tumors

  • Authors:
    • Guzin Gonullu Demirag
    • Mehmet Kefeli
    • Yasemin Kemal
    • Idris Yucel
  • View Affiliations

  • Published online on: February 8, 2016     https://doi.org/10.3892/ol.2016.4202
  • Pages: 2140-2144
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Abstract

The present study aimed to analyze the clinical significance of epithelial membrane protein 1 (EMP1) expression in ovarian serous tumors. A total of 84 cases of ovarian serous tumor (50 patients with malignant ovarian serous tumors and 34 patients with borderline and benign serous tumors) were retrospectively analyzed. Differences in the expression levels of EMP1 between the malignant and non‑malignant tumor groups were evaluated by immunohistochemical staining. In addition, the association between EMP1 expression and prognostic factors in malignant ovarian serous tumors was investigated. The expression levels of EMP1 were significantly reduced in all the 50 malignant ovarian serous tumors, compared with the 34 non‑malignant ovarian serous tumors (P<0.000). Reduced expression of EMP1 was correlated with high grade (P=0.009) and stage (P<0.000) of malignant tumors. EMP1 expression was not observed to be correlated with any other investigated parameters, including surgery, type of operation and chemotherapy response (P>0.005). These results indicated that EMP1 may have a significant role as a negative regulator in ovarian serous tumors, and reduced EMP1 expression in serous tumors may be associated with increased disease severity.
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March-2016
Volume 11 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Demirag GG, Kefeli M, Kemal Y and Yucel I: Epithelial membrane protein 1 expression in ovarian serous tumors. Oncol Lett 11: 2140-2144, 2016
APA
Demirag, G.G., Kefeli, M., Kemal, Y., & Yucel, I. (2016). Epithelial membrane protein 1 expression in ovarian serous tumors. Oncology Letters, 11, 2140-2144. https://doi.org/10.3892/ol.2016.4202
MLA
Demirag, G. G., Kefeli, M., Kemal, Y., Yucel, I."Epithelial membrane protein 1 expression in ovarian serous tumors". Oncology Letters 11.3 (2016): 2140-2144.
Chicago
Demirag, G. G., Kefeli, M., Kemal, Y., Yucel, I."Epithelial membrane protein 1 expression in ovarian serous tumors". Oncology Letters 11, no. 3 (2016): 2140-2144. https://doi.org/10.3892/ol.2016.4202