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Case Report

Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature

  • Authors:
    • Hua‑Ping Du
    • Qian‑Qian Yang
    • Ye Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China
  • Pages: 2310-2314
    |
    Published online on: February 9, 2016
       https://doi.org/10.3892/ol.2016.4213
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Abstract

The peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive neoplasms that account for <15% of all non‑Hodgkin's lymphoma cases in adults. Angioimmunoblastic T-cell lymphoma (AITL) is a specific subtype of PTCL. The tumor is frequently aggressive and there is currently no general consensus regarding an effective treatment strategy. The present study reports a case in which bortezomib combined with dexamethasone was used to treat refractory AITL. A 63‑year‑old woman was admitted to Sir Run Run Shaw Hospital, Zhejiang University School of Medicine (Zhejiang, China) on August 17, 2013. The patient had been diagnosed with AITL for 4 months and had experienced a relapse of symptoms for the 4 days prior to admission. The patient demonstrated fever and dyspnea, accompanied by severe edema in the face and lower limbs, which later spread to the right upper limb. The patient was treated with bortezomib plus dexamethasone, which rapidly relieved the symptoms. The patient was subsequently administered an additional 2 cycles of bortezomib‑based chemotherapy and survived for an additional 4 months, prior to succumbing to the disease. Only a small number of studies have reported the use of bortezomib in the treatment of T‑cell lymphoma. The present study suggested that bortezomib‑based treatment may be a reliable, safe and effective alternative for the treatment of relapsed/refractory PTCL. The efficacy of bortezomib as a treatment for PTCL requires additional evaluation in future studies.
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Copy and paste a formatted citation
Spandidos Publications style
Du HP, Yang QQ and Zhang Y: Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature. Oncol Lett 11: 2310-2314, 2016.
APA
Du, H., Yang, Q., & Zhang, Y. (2016). Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature. Oncology Letters, 11, 2310-2314. https://doi.org/10.3892/ol.2016.4213
MLA
Du, H., Yang, Q., Zhang, Y."Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature". Oncology Letters 11.3 (2016): 2310-2314.
Chicago
Du, H., Yang, Q., Zhang, Y."Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature". Oncology Letters 11, no. 3 (2016): 2310-2314. https://doi.org/10.3892/ol.2016.4213
Copy and paste a formatted citation
x
Spandidos Publications style
Du HP, Yang QQ and Zhang Y: Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature. Oncol Lett 11: 2310-2314, 2016.
APA
Du, H., Yang, Q., & Zhang, Y. (2016). Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature. Oncology Letters, 11, 2310-2314. https://doi.org/10.3892/ol.2016.4213
MLA
Du, H., Yang, Q., Zhang, Y."Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature". Oncology Letters 11.3 (2016): 2310-2314.
Chicago
Du, H., Yang, Q., Zhang, Y."Bortezomib-based chemotherapy to treat refractory angioimmunoblastic T-cell lymphoma: A case report and review of the literature". Oncology Letters 11, no. 3 (2016): 2310-2314. https://doi.org/10.3892/ol.2016.4213
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