Chronic myeloid leukaemia following repeated exposure to chest radiography and computed tomography in a patient with pneumothorax: A case report and literature review

Ju,Fang‑He; Gong,Xu‑Bo; Jiang,Li‑Bin; Hong,Hui‑Hua; Yang,Jun‑Chao; Xu,Ting‑Zhen; Chen,Yu; Wang,Zhen

doi:10.3892/ol.2016.4236

April-2016 Volume 11 Issue 4

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April-2016 Volume 11 Issue 4

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Case Report Open Access

Chronic myeloid leukaemia following repeated exposure to chest radiography and computed tomography in a patient with pneumothorax: A case report and literature review

Authors:
- Fang‑He Ju
- Xu‑Bo Gong
- Li‑Bin Jiang
- Hui‑Hua Hong
- Jun‑Chao Yang
- Ting‑Zhen Xu
- Yu Chen
- Zhen Wang
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang 310006, P.R. China, Department of Clinical Laboratory, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China

Copyright: © Ju et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2398-2402
|
Published online on: February 17, 2016

https://doi.org/10.3892/ol.2016.4236
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Abstract

It is well known that radioactive rays may cause damage to the human body. Progress in modern medicine has led to an increased risk of therapeutic and diagnostic radiation exposure of patients. Although clear evidence of a radiation dose‑dependent risk of chronic myeloid leukaemia, particularly for patients exposed to radiation at a young age, has been established, it is not known whether radiation exposure during diagnostic imaging also increases the risk of cancer. The present study reports the case of a patient who underwent several diagnostic imaging tests (including repeated chest radiography and computed tomography) for recurrent pneumothorax. At around one year subsequent to these tests, the patient was diagnosed with chronic myeloid leukaemia. The patient exhibited an increase in white blood cell count over time, and a bone marrow smear test showed a myeloid/erythroid ratio of 13.9:1. In addition, the qualitative breakpoint cluster region (BCR)/Abelson (ABL) gene test revealed positive results for BCR/ABL fusion (p210). Based on the data reported in the current case, research aimed at elucidating the potential risks associated with diagnostic radiation is urgently required. It is crucial that medical professionals consider the potential harmful side effects of diagnostic radiation when ordering radiation‑based diagnostic imaging examinations.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Chronic myeloid leukaemia following repeated exposure to chest radiography and computed tomography in a patient with pneumothorax: A case report and literature review

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