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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2016 Volume 11 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Case Report

Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report

  • Authors:
    • Jing Zhang
    • Zhi‑Jun Wang
    • Bin Yang
    • You‑Ying Wei
    • Ling Yang
    • Yang Hu
    • Yan‑Ping Hu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Hubei Cancer Hospital, Wuhan, Hubei 430079, P.R. China
  • Pages: 2615-2618
    |
    Published online on: February 18, 2016
       https://doi.org/10.3892/ol.2016.4248
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Abstract

Primary mediastinal choriocarcinoma is a rare malignancy that is characterized by multiple metastases at the time of diagnosis, poor response to therapy and short survival times. There is no standard treatment for this disease. The present study described the case of a 25‑year‑old man with metastatic mediastinal choriocarcinoma. The patient completed 8 cycles of standard combination chemotherapy consisting of etoposide [100 mg/m2; intravenous (IV) drip on days 1-3], cisplatin (20 mg/m2; IV drip on days 1-5) and bleomycin (20 mg/m2; intramuscular injection on days 1, 8 and 15 every 21 days). The α‑fetoprotein level decreased to 2.36 ng/ml, the serum β‑human chorionic gonadotropin (β‑HCG) level markedly decreased to 8.69 IU/l, which was slightly higher than the normal upper limit, and the lactate dehydrogenase level decreased to a normal range. The computed tomography (CT) scan revealed that the number and size of the lung lesions was significantly reduced subsequent to 8 cycles of chemotherapy and the size of the mediastinal tumor was evidently reduced, with a less solid component and a more cystic component. The response assessment indicated partial remission. Following chemotherapy, a radiation dose of 50 Gy (2.0 Gy/fraction) was administered to the involved field of the mediastinum. Following radiotherapy, the β‑HCG level had also decreased to normal levels, and CT evaluation revealed that the size of the residual lung lesions demonstrated no evident change, and the mediastinal tumor was slightly reduced in size, with a less solid component. The patient refused to undergo surgery and did not receive additional treatment following radiotherapy. At present, the patient has survived >16 months of follow-up without any symptoms.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Wang ZJ, Yang B, Wei YY, Yang L, Hu Y and Hu YP: Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report. Oncol Lett 11: 2615-2618, 2016.
APA
Zhang, J., Wang, Z., Yang, B., Wei, Y., Yang, L., Hu, Y., & Hu, Y. (2016). Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report. Oncology Letters, 11, 2615-2618. https://doi.org/10.3892/ol.2016.4248
MLA
Zhang, J., Wang, Z., Yang, B., Wei, Y., Yang, L., Hu, Y., Hu, Y."Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report". Oncology Letters 11.4 (2016): 2615-2618.
Chicago
Zhang, J., Wang, Z., Yang, B., Wei, Y., Yang, L., Hu, Y., Hu, Y."Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report". Oncology Letters 11, no. 4 (2016): 2615-2618. https://doi.org/10.3892/ol.2016.4248
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Wang ZJ, Yang B, Wei YY, Yang L, Hu Y and Hu YP: Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report. Oncol Lett 11: 2615-2618, 2016.
APA
Zhang, J., Wang, Z., Yang, B., Wei, Y., Yang, L., Hu, Y., & Hu, Y. (2016). Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report. Oncology Letters, 11, 2615-2618. https://doi.org/10.3892/ol.2016.4248
MLA
Zhang, J., Wang, Z., Yang, B., Wei, Y., Yang, L., Hu, Y., Hu, Y."Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report". Oncology Letters 11.4 (2016): 2615-2618.
Chicago
Zhang, J., Wang, Z., Yang, B., Wei, Y., Yang, L., Hu, Y., Hu, Y."Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report". Oncology Letters 11, no. 4 (2016): 2615-2618. https://doi.org/10.3892/ol.2016.4248
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