Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study

Tatangelo,Fabiana; Cantile,Monica; Collina,Francesca; Belli,Andrea; De Franciscis,Silvia; Bianco,Franco; Botti,Gerardo

doi:10.3892/ol.2016.4281

April-2016 Volume 11 Issue 4

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April-2016 Volume 11 Issue 4

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Case Report

Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study

Authors:
- Fabiana Tatangelo
- Monica Cantile
- Francesca Collina
- Andrea Belli
- Silvia De Franciscis
- Franco Bianco
- Gerardo Botti
View Affiliations / Copyright

Affiliations: Pathology Unit, National Cancer Institute ‘G. Pascale’ Foundation, Naples, Campania 80131, Italy, Department of General and Hepato-Pancreato-Biliary Surgery, National Cancer Institute ‘G. Pascale’ Foundation, Naples, Campania 80131, Italy
Pages: 2497-2501
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Published online on: February 25, 2016

https://doi.org/10.3892/ol.2016.4281
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Abstract

Schwannomas are tumors derived from Schwann cells. Generally, they are benign and their typical site of origin is the subcutaneous tissue of the distal extremities or of the head and neck region. Gastrointestinal localization of schwannomas is extremely rare, and the stomach is the prevalent site. The present study describes the case of a gastric schwannoma in a 61-year-old male who underwent subtotal gastrectomy following a clinical diagnosis of a gastrointestinal stromal tumor (GIST). A histological, immunohistochemical and molecular study was performed to exclude the misdiagnosis of GIST. The histomorphological features of the lesion and absence of c-Kit and PDGFRA mutations indicated the diagnosis of gastric schwannoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study

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