Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study

  • Authors:
    • Fabiana Tatangelo
    • Monica Cantile
    • Francesca Collina
    • Andrea Belli
    • Silvia De Franciscis
    • Franco Bianco
    • Gerardo Botti
  • View Affiliations

  • Published online on: February 25, 2016     https://doi.org/10.3892/ol.2016.4281
  • Pages: 2497-2501
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Abstract

Schwannomas are tumors derived from Schwann cells. Generally, they are benign and their typical site of origin is the subcutaneous tissue of the distal extremities or of the head and neck region. Gastrointestinal localization of schwannomas is extremely rare, and the stomach is the prevalent site. The present study describes the case of a gastric schwannoma in a 61-year-old male who underwent subtotal gastrectomy following a clinical diagnosis of a gastrointestinal stromal tumor (GIST). A histological, immunohistochemical and molecular study was performed to exclude the misdiagnosis of GIST. The histomorphological features of the lesion and absence of c-Kit and PDGFRA mutations indicated the diagnosis of gastric schwannoma.
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April-2016
Volume 11 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tatangelo F, Cantile M, Collina F, Belli A, De Franciscis S, Bianco F and Botti G: Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study. Oncol Lett 11: 2497-2501, 2016
APA
Tatangelo, F., Cantile, M., Collina, F., Belli, A., De Franciscis, S., Bianco, F., & Botti, G. (2016). Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study. Oncology Letters, 11, 2497-2501. https://doi.org/10.3892/ol.2016.4281
MLA
Tatangelo, F., Cantile, M., Collina, F., Belli, A., De Franciscis, S., Bianco, F., Botti, G."Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study". Oncology Letters 11.4 (2016): 2497-2501.
Chicago
Tatangelo, F., Cantile, M., Collina, F., Belli, A., De Franciscis, S., Bianco, F., Botti, G."Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study". Oncology Letters 11, no. 4 (2016): 2497-2501. https://doi.org/10.3892/ol.2016.4281