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Article

ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer

  • Authors:
    • Li Lu
    • Hao Zhang
    • Jun Pang
    • Guo‑Liang Hou
    • Min‑Hua Lu
    • Xin Gao
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China
  • Pages: 2532-2538
    |
    Published online on: February 25, 2016
       https://doi.org/10.3892/ol.2016.4282
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Abstract

Currently, there are no well-established preoperative clinicopathological parameters for predicting extra-prostatic extension (EPE) in patients with clinically localised prostate cancer (PCa). The transmembrane protease serine 2 (TMPRSS2)‑ETS‑related gene (ERG) fusion gene is a specific biomarker of PCa and is considered a prognostic predictor. The aim of the present study was to assess the value of this marker for predicting EPE in patients with clinically localised PCa. In total, 306 PCa patients with clinically localised disease, including 220 patients (71.9%) with organ‑confined disease and 86 EPE cases (28.1%), were included in the study. Receiver operating characteristic curves and logistic regression were employed to establish the optimal cut‑off value and to investigate whether ERG rearrangement was an independent predictor for the EPE of clinically localised PCa. A leave‑one‑out cross‑validation (LOOCV) model was implemented to validate the predictive power of ERG rearrangement. An increase in ERG rearrangements was identified to be associated with EPE, and the optimal cut‑off for predicting EPE was determined to be 2.25%, with a sensitivity of 70.24% [95% confidence interval (CI), 62.6‑78.9%], a specificity of 80.43% (95% CI, 75.4‑85.1%), and an area under the curve (AUC) of 0.781 (95% CI, 0.730‑0.826). In the LOOCV model, ERG rearrangement also demonstrated good performance for predicting EPE (sensitivity, 76.923%; specificity, 71.429%; 95% CI for AUC, 0.724-0.958). In addition, a high Gleason score (≥7) and a cT2c classification upon biopsy were independent factors for EPE.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Heidenreich A, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, Mottet N, Schmid HP, van der Kwast T, Wiegel T and Zattoni F: European Association of Urology: EAU guidelines on prostate cancer. Part 1: Screening, diagnosis and treatment of clinically localised disease. Eur Urol. 59:61–71. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Eifler JB, Feng Z, Lin BM, Partin MT, Humphreys EB, Han M, Epstein JI, Walsh PC, Trock BJ and Partin AW: An updated prostate cancer staging nomogram (Partin tables) based on cases from 2006 to 2011. BJU Int. 111:22–29. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Hull GW, Rabbani F, Abbas F, Wheeler TM, Kattan MW and Scardino PT: Cancer control with radical prostatectomy alone in 1,000 consecutive patients. J Urol. 167:528–534. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Masieri L, Minervini A, Vittori G, Lanciotti M, Lanzi F, Lapini A, Carini M and Serni S: The role of free to total PSA ratio in prediction of extracapsular tumor extension and biochemical recurrence after radical prostatectomy in patients with PSA between 4 and 10 ng/ml. Int Urol Nephrol. 44:1031–1038. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Magi-Galluzzi C, Evans AJ, Delahunt B, Epstein JI, Griffiths DF, van der Kwast TH, Montironi R, Wheeler TM, Srigley JR, Egevad LL and Humphrey PA: ISUP Prostate: International society of urological pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens. Working group 3: Extraprostatic extension, lymphovascular invasion and locally advanced disease. Mod Pathol. 24:26–38. 2011. View Article : Google Scholar : PubMed/NCBI

7 

van Veggel BA, van Oort IM, Witjes JA, Kiemeney LA and de Hulsbergen-van Kaa CA: Quantification of extraprostatic extension in prostate cancer: Different parameters correlated to biochemical recurrence after radical prostatectomy. Histopathology. 59:692–702. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Roethke MC, Lichy MP, Kniess M, Werner MK, Claussen CD, Stenzl A, Schlemmer HP and Schilling D: Accuracy of preoperative endorectal MRI in predicting extracapsular extension and influence on neurovascular bundle sparing in radical prostatectomy. World J Urol. 31:1111–1116. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Eisenberg ML, Cowan JE, Davies BJ, Carroll PR and Shinohara K: The importance of tumor palpability and transrectal ultrasonographic appearance in the contemporary clinical staging of prostate cancer. Urol Oncol. 29:171–176. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Schwartz DJ, Sengupta S, Hillman DW, Sargent DJ, Cheville JC, Wilson TM, Mynderse LA, Choo R and Davis BJ: Prediction of radial distance of extraprostatic extension from pretherapy factors. Int J Radiat Oncol Biol Phys. 69:411–418. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Brassell SA, Kao TC, Sun L and Moul JW: Prostate-specific antigen versus prostate-specific antigen density as predictor of tumor volume, margin status, pathologic stage and biochemical recurrence of prostate cancer. Urology. 66:1229–1233. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Magheli A, Rais-Bahrami S, Trock BJ, Humphreys EB, Partin AW, Han M and Gonzalgo ML: Prostate specific antigen versus prostate specific antigen density as a prognosticator of pathological characteristics and biochemical recurrence following radical prostatectomy. J Urol. 179:1780–1784, 1784; discussion. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Kumar-Sinha C, Tomlins SA and Chinnaiyan AM: Recurrent gene fusions in prostate cancer. Nat Rev Cancer. 8:497–511. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Tomlins SA, Bjartell A, Chinnaiyan AM, Jenster G, Nam RK, Rubin MA and Schalken JA: ETS gene fusions in prostate cancer: From discovery to daily clinical practice. Eur Urol. 56:275–286. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Clark JP and Cooper CS: ETS gene fusions in prostate cancer. Nat Rev Urol. 6:429–439. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Sun QP, Li LY, Chen Z, Pang J, Yang WJ, Zhou XF, Qiu JG, Su ZL, He D and Gao X: Detection of TMPRSS2-ETS fusions by a multiprobe fluorescence in situ hybridization assay for the early diagnosis of prostate cancer: A pilot study. J Mol Diagn. 12:718–724. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Gao X, Li LY, Zhou FJ, Xie KJ, Shao CK, Su ZL, Sun QP, Chen MK, Pang J, Zhou XF, et al: ERG rearrangement for predicting subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia and lymph node metastasis. Clin Cancer Res. 18:4163–4172. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, et al: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 310:644–648. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumours (7th). Wiley-Blackwell. Hoboken, NJ: 2010.

20 

Epstein JI: An update of the Gleason grading system. J Urol. 183:433–440. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Epstein JI, Partin AW, Sauvageot J and Walsh PC: Prediction of progression following radical prostatectomy. A multivariate analysis of 721 men with long-term follow-up. Am J Surg Pathol. 20:286–292. 1996. View Article : Google Scholar : PubMed/NCBI

22 

Sakr WA, Wheeler TM, Blute M, Bodo M, Calle-Rodrigue R, Henson DE, Mostofi FK, Seiffert J, Wojno K and Zincke H: Staging and reporting of prostate cancer-sampling of the radical prostatectomy specimen. Cancer. 78:366–368. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Yu JB, Makarov DV, Sharma R, Peschel RE, Partin AW and Gross CP: Validation of the partin nomogram for prostate cancer in a national sample. J Urol. 183:105–111. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Karakiewicz PI, Bhojani N, Capitanio U, Reuther AM, Suardi N, Jeldres C, Pharand D, Péloquin F, Perrotte P, Shariat SF and Klein EA: External validation of the updated Partin tables in a cohort of North American men. J Urol. 180:898–902; discussion 902–903. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Pepe P, Fraggetta F, Galia A and Aragona F: Is PCA3 score useful in preoperative staging of a single microfocus of prostate cancer diagnosed at saturation biopsy? Urol Int. 89:143–147. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Xu B, Chevarie-Davis M, Chevalier S, Scarlata E, Zeizafoun N, Dragomir A, Tanguay S, Kassouf W, Aprikian A and Brimo F: The prognostic role of ERG immunopositivity in prostatic acinar adenocarcinoma: A study including 454 cases and review of the literature. Hum Pathol. 45:488–497. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Hermans KG, van Marion R, van Dekken H, Jenster G, van Weerden WM and Trapman J: TMPRSS2: ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer. Cancer Res. 66:10658–10663. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Perner S, Demichelis F, Beroukhim R, Schmidt FH, Mosquera JM, Setlur S, Tchinda J, Tomlins SA, Hofer MD, Pienta KG, et al: TMPRSS2: ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res. 66:8337–8341. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Attard G, Clark J, Ambroisine L, Fisher G, Kovacs G, Flohr P, Berney D, Foster CS, Fletcher A, Gerald WL, et al: Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. Oncogene. 27:253–263. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Hofer MD, Kuefer R, Maier C, Herkommer K, Perner S, Demichelis F, Paiss T, Vogel W, Rubin MA and Hoegel J: Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer. Cancer Res. 69:640–646. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Rajput AB, Miller MA, De Luca A, Boyd N, Leung S, Hurtado-Coll A, Fazli L, Jones EC, Palmer JB, Gleave ME, et al: Frequency of the TMPRSS2: ERG gene fusion is increased in moderate to poorly differentiated prostate cancers. J Clin Pathol. 60:1238–1243. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Pettersson A, Graff RE, Bauer SR, Pitt MJ, Lis RT, Stack EC, Martin NE, Kunz L, Penney KL, Ligon AH, et al: The TMPRSS2: ERG rearrangement, ERG expression and prostate cancer outcomes: A cohort study and meta-analysis. Cancer Epidemiol Biomarkers Prev. 21:1497–1509. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Furusato B, van Leenders GJ, Trapman J, Kimura T, Egawa S, Takahashi H, Furusato M, Visakorpi T and Hano H: Immunohistochemical ETS-related gene detection in a Japanese prostate cancer cohort: Diagnostic use in Japanese prostate cancer patients. Pathol Int. 61:409–414. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA and Teixeira MR: FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer. Genes Chromosomes Cancer. 51:240–249. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Minner S, Enodien M, Sirma H, Luebke AM, Krohn A, Mayer PS, Simon R, Tennstedt P, Müller J, Scholz L, et al: ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy. Clin Cancer Res. 17:5878–5888. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Partin AW, Kattan MW, Subong EN, Walsh PC, Wojno KJ, Oesterling JE, Scardino PT and Pearson JD: Combination of prostate-specific antigen, clinical stage and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update. JAMA. 277:1445–1451. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Huang Y, Isharwal S, Haese A, Chun FK, Makarov DV, Feng Z, Han M, Humphreys E, Epstein JI, Partin AW and Veltri RW: Prediction of patient-specific risk and percentile cohort risk of pathological stage outcome using continuous prostate-specific antigen measurement, clinical stage and biopsy Gleason score. BJU Int. 107:1562–1569. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Paquette EL, Connelly RR, Sun L, Paquette LR and Moul JW: Predictors of extracapsular extension and positive margins in African American and white men. Urol Oncol. 21:33–38. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Nishimoto K, Nakashima J, Hashiguchi A, Kikuchi E, Miyajima A, Nakagawa K, Ohigashi T, Oya M and Murai M: Prediction of extraprostatic extension by prostate specific antigen velocity, endorectal MRI and biopsy Gleason score in clinically localized prostate cancer. Int J Urol. 15:520–523. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Giannarini G, Scott CA, Moro U, Pertoldi B, Beltrami CA and Selli C: Are PSA density and PSA density of the transition zone more accurate than PSA in predicting the pathological stage of clinically localized prostate cancer? Urol Oncol. 26:353–360. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Lin S, Zhang Q, Li P, Li Z, Sun Y, Shao Y, Zhang X and Fu S: Prediction of extraprostatic extension in patients with clinically organ-confined prostate cancer. Urol Int. 92:282–8. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu L, Zhang H, Pang J, Hou GL, Lu MH and Gao X: ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer. Oncol Lett 11: 2532-2538, 2016.
APA
Lu, L., Zhang, H., Pang, J., Hou, G., Lu, M., & Gao, X. (2016). ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer. Oncology Letters, 11, 2532-2538. https://doi.org/10.3892/ol.2016.4282
MLA
Lu, L., Zhang, H., Pang, J., Hou, G., Lu, M., Gao, X."ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer". Oncology Letters 11.4 (2016): 2532-2538.
Chicago
Lu, L., Zhang, H., Pang, J., Hou, G., Lu, M., Gao, X."ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer". Oncology Letters 11, no. 4 (2016): 2532-2538. https://doi.org/10.3892/ol.2016.4282
Copy and paste a formatted citation
x
Spandidos Publications style
Lu L, Zhang H, Pang J, Hou GL, Lu MH and Gao X: ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer. Oncol Lett 11: 2532-2538, 2016.
APA
Lu, L., Zhang, H., Pang, J., Hou, G., Lu, M., & Gao, X. (2016). ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer. Oncology Letters, 11, 2532-2538. https://doi.org/10.3892/ol.2016.4282
MLA
Lu, L., Zhang, H., Pang, J., Hou, G., Lu, M., Gao, X."ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer". Oncology Letters 11.4 (2016): 2532-2538.
Chicago
Lu, L., Zhang, H., Pang, J., Hou, G., Lu, M., Gao, X."ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer". Oncology Letters 11, no. 4 (2016): 2532-2538. https://doi.org/10.3892/ol.2016.4282
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