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April-2016 Volume 11 Issue 4

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Article

MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma

  • Authors:
    • Tingyan Ruan
    • Xiaoting He
    • Jun Yu
    • Zhiqiang Hang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China, Department of Thoracic Surgery, The Second People's Hospital of Wuxi, Wuxi, Jiangsu 214002, P.R. China
  • Pages: 2941-2945
    |
    Published online on: March 8, 2016
       https://doi.org/10.3892/ol.2016.4312
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Abstract

Liver cancer, particularly hepatocellular carcinoma (HCC), is one of leading causes of cancer-related mortality worldwide. Upregulation of the evolutionary conserved Hippo signaling pathway has been observed in HCC patients, and Yes‑associated protein 1 (YAP1) has been reported to play a key role in HCC tumorigenesis. microRNAs (miRNAs) are a family of small non-coding RNAs, usually 21-25 nucleotides in length, and are essential in the regulation of gene expression. Abnormal miRNA expression has been implicated in the initiation and progression of numerous forms of cancers, including liver cancer. Here, we report the identification of a novel miRNA, miR‑186, and its functions as an HCC tumor suppressor. We observed that miR‑186 was downregulated in several HCC cell lines, and that it directly targets YAP1 mRNA. Overexpression of miR‑186 in HCC cells significantly downregulates YAP1 mRNA and protein levels, leading to downregulation of the Hippo signaling pathway, which in turn severely inhibits HCC cell migration, invasion and proliferation. Our study is the first to report the direct involvement of miR-186 in downregulating YAP1 and, more significantly, inhibiting HCC tumorigenesis, and supports the role miR-186 as a potential therapeutic target in treating liver cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ruan T, He X, Yu J and Hang Z: MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma. Oncol Lett 11: 2941-2945, 2016.
APA
Ruan, T., He, X., Yu, J., & Hang, Z. (2016). MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma. Oncology Letters, 11, 2941-2945. https://doi.org/10.3892/ol.2016.4312
MLA
Ruan, T., He, X., Yu, J., Hang, Z."MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma". Oncology Letters 11.4 (2016): 2941-2945.
Chicago
Ruan, T., He, X., Yu, J., Hang, Z."MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma". Oncology Letters 11, no. 4 (2016): 2941-2945. https://doi.org/10.3892/ol.2016.4312
Copy and paste a formatted citation
x
Spandidos Publications style
Ruan T, He X, Yu J and Hang Z: MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma. Oncol Lett 11: 2941-2945, 2016.
APA
Ruan, T., He, X., Yu, J., & Hang, Z. (2016). MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma. Oncology Letters, 11, 2941-2945. https://doi.org/10.3892/ol.2016.4312
MLA
Ruan, T., He, X., Yu, J., Hang, Z."MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma". Oncology Letters 11.4 (2016): 2941-2945.
Chicago
Ruan, T., He, X., Yu, J., Hang, Z."MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma". Oncology Letters 11, no. 4 (2016): 2941-2945. https://doi.org/10.3892/ol.2016.4312
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