Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2016 Volume 11 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2016 Volume 11 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis

  • Authors:
    • Zhitao Jing
    • Long Li
    • Xin Wang
    • Minghao Wang
    • Ying Cai
    • Zi Jin
    • Ye Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Jing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2787-2791
    |
    Published online on: March 9, 2016
       https://doi.org/10.3892/ol.2016.4318
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Casitas B-lineage lymphoma (c-Cbl) expression has been linked to the development of several types of cancer. However, no studies on the association of c-Cbl and glioma have been published thus far. The present study examined glioma samples obtained from 136 patients treated at The First Hospital of China Medical University (Shenyang, China) from January 2007 to December 2009, and the expression levels of c‑Cbl in the samples were evaluated by reverse transcription‑quantitative polymerase chain reaction, immunohistochemistry and western blotting. Kaplan‑Meier survival curves were generated and subjected to Cox regression analysis. The messenger RNA and protein levels of c‑Cbl were observed to be upregulated in high‑grade glioma, compared with low‑grade glioma. A multivariate analysis revealed that the protein levels of c‑Cbl were independently associated with overall survival [hazard ratio (HR)=4.923, 95% confidence interval (CI)=3.163‑7.662; P<0.001]. Furthermore, the grade of the glioma (according to the World Health Organization criteria) was observed to be independent prognostic factors for progression‑free survival and overall survival time (HR=8.842, 95% CI=7.827‑9.989; P<0.001, and HR=10.247, 95% CI=9.009‑11.655; P<0.001, respectively). Kaplan‑Meier analysis and log‑rank test indicated that high protein expression levels of c‑Cbl were significantly associated with overall and progression‑free survival (P<0.001). To the best of our knowledge, these results provide the first evidence that the overexpression of c-Cbl is correlated with advanced clinicopathological features and poor prognosis in patients with glioma.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ma R, de Pennington N, Hofer M, Blesing C and Stacey R: Diagnostic and prognostic markers in gliomas - an update. Br J Neurosurg. 27:311–315. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Hentschel SJ and Lang FF: Current surgical management of glioblastoma. Cancer J. 9:113–125. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Diamond EL, Corner GW, De Rosa A, Breitbart W and Applebaum AJ: Prognostic awareness and communication of prognostic information in malignant glioma: A systematic review. J Neurooncol. 119:227–234. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Clarke J, Butowski N and Chang S: Recent advances in therapy for glioblastoma. Arch Neurol. 67:279–283. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Andoniou CE, Thien CB and Langdon WY: Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J. 13:4515–4523. 1994.PubMed/NCBI

6 

Thien CB and Langdon WY: Cbl: Many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol. 2:294–307. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Di Fiore PP and De Camilli P: Endocytosis and signaling. An inseparable partnership. Cell. 106:1–4. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Joazeiro CA and Hunter T: Biochemistry. Ubiquitination - more than two to tango. Science. 289:2061–2062. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Waterman H and Yarden Y: Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett. 490:142–152. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Mohapatra B, Ahmad G, Nadeau S, Zutshi N, An W, Scheffe S, Dong L, Feng D, Goetz B, Arya P, et al: Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases. Biochim Biophys Acta. 1833:122–139. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Ito R, Nakayama H, Yoshida K, Matsumura S, Oda N and Yasui W: Expression of Cbl linking with the epidermal growth factor receptor system is associated with tumor progression and poor prognosis of human gastric carcinoma. Virchows Arch. 444:324–331. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Cristóbal I, Manso R, Rincón R, Caramés C, Madoz-Gúrpide J, Rojo F and García-Foncillas J: Up-regulation of c-Cbl suggests its potential role as oncogene in primary colorectal cancer. Int J Colorectal Dis. 29:6412014. View Article : Google Scholar : PubMed/NCBI

13 

Knight JF, Shepherd CJ, Rizzo S, Brewer D, Jhavar S, Dodson AR, Cooper CS, Eeles R, Falconer A, Kovacs G, et al: TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer. Br J Cancer. 99:1849–1858. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Tan YH, Krishnaswamy S, Nandi S, Kanteti R, Vora S, Onel K, Hasina R, Lo FY, El-Hashani E, Cervantes G, et al: CBL is frequently altered in lung cancers: Its relationship to mutations in MET and EGFR tyrosine kinases. PLoS One. 5:e89722010.Hsu HH [added]. View Article : Google Scholar : PubMed/NCBI

15 

Shibuya N, Inoue K, Tanaka G, Akimoto K and Kubota K: Augmented pentose phosphate pathway plays critical roles in colorectal carcinomas. Oncology. 88:309–319. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Makishima H, Cazzolli H, Szpurka H, Dunbar A, Tiu R, Huh J, Muramatsu H, O'Keefe C, Hsi E, Paquette RL, et al: Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. J Clin Oncol. 27:6109–6116. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Nam JM, Onodera Y, Mazaki Y, Miyoshi H, Hashimoto S and Sabe H: CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery. EMBO J. 26:647–656. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Chiusaroli R, Sanjay A, Henriksen K, Engsig MT, Horne WC, Gu H and Baron R: Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones. Dev Biol. 261:537–547. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Caveggion E, Continolo S, Pixley FJ, Stanley ER, Bowtell DD, Lowell CA and Berton G: Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. J Cell Physiol. 195:276–289. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Lee H and Tsygankov AY: c-Cbl regulates glioma invasion through matrix metalloproteinase 2. J Cell Biochem. 111:1169–1178. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jing Z, Li L, Wang X, Wang M, Cai Y, Jin Z and Zhang Y: High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis. Oncol Lett 11: 2787-2791, 2016.
APA
Jing, Z., Li, L., Wang, X., Wang, M., Cai, Y., Jin, Z., & Zhang, Y. (2016). High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis. Oncology Letters, 11, 2787-2791. https://doi.org/10.3892/ol.2016.4318
MLA
Jing, Z., Li, L., Wang, X., Wang, M., Cai, Y., Jin, Z., Zhang, Y."High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis". Oncology Letters 11.4 (2016): 2787-2791.
Chicago
Jing, Z., Li, L., Wang, X., Wang, M., Cai, Y., Jin, Z., Zhang, Y."High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis". Oncology Letters 11, no. 4 (2016): 2787-2791. https://doi.org/10.3892/ol.2016.4318
Copy and paste a formatted citation
x
Spandidos Publications style
Jing Z, Li L, Wang X, Wang M, Cai Y, Jin Z and Zhang Y: High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis. Oncol Lett 11: 2787-2791, 2016.
APA
Jing, Z., Li, L., Wang, X., Wang, M., Cai, Y., Jin, Z., & Zhang, Y. (2016). High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis. Oncology Letters, 11, 2787-2791. https://doi.org/10.3892/ol.2016.4318
MLA
Jing, Z., Li, L., Wang, X., Wang, M., Cai, Y., Jin, Z., Zhang, Y."High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis". Oncology Letters 11.4 (2016): 2787-2791.
Chicago
Jing, Z., Li, L., Wang, X., Wang, M., Cai, Y., Jin, Z., Zhang, Y."High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis". Oncology Letters 11, no. 4 (2016): 2787-2791. https://doi.org/10.3892/ol.2016.4318
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team