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Case Report

Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature

  • Authors:
    • Chuangzhi Zhu
    • Aiping Zheng
    • Xiangming Mao
    • Bentao Shi
    • Xianxin Li
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China
  • Pages: 3117-3122
    |
    Published online on: March 17, 2016
       https://doi.org/10.3892/ol.2016.4342
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Abstract

Adrenal sarcomatoid carcinoma is a rare adrenal carcinoma. To the best of our knowledge, only 11 cases have been reported since 1987. Adrenal sarcomatoid carcinoma presents a diagnostic challenge due to its atypical symptoms and histological patterns. At the time of diagnosis, a large percentage of patients are already at the metastatic stage and succumb within a few months. The present study reports a case of a 59‑year‑old man presenting with asthenia and weight loss with adrenal sarcomatoid carcinoma metastatic to the lung. A computed tomography (CT) scan and ultrasonography of the patient's abdomen suggested a large homogeneous mass in the right adrenal gland, and a CT scan of his chest suggested lung metastasis. Right adrenalectomy was performed. Histological examination revealed that the tumor was composed of sarcomatous and carcinomatous differentiation elements. Immunohistochemical examination revealed tumor cell positivity for vimentin and cytokeratin. At the 6‑month follow‑up the patient exhibited no disease progression and refused further proposed treatment. The patient was alive at the time of writing the current report. The present case report additionally reviews the literature, for the purpose of raising awareness of these rare lesions and assisting in achieving accurate diagnoses and effective treatment.
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1 

Roman S: Adrenocortical carcinoma. Curr Opin Oncol. 18:36–42. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Ng L and Libertino JM: Adrenocortical carcinoma: Diagnosis, evaluation and treatment. J Urol. 169:5–11. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Weidner N: Sarcomatoid carcinoma of the upper aerodigestive tract. Semin Diagn Pathol. 4:157–168. 1987.PubMed/NCBI

4 

Zarbo RJ, Crissman JD, Venkat H and Weiss MA: Spindle-cell carcinoma of the upper aerodigestive tract mucosa. An immunohistologic and ultrastructural study of 18 biphasic tumors and comparison with seven monophasic spindle-cell tumors. Am J Surg Pathol. 10:741–753. 1986. View Article : Google Scholar : PubMed/NCBI

5 

Oberman HA: Metaplastic carcinoma of the breast. A clinicopathologic study of 29 patients. Am J Surg Pathol. 11:918–929. 1987. View Article : Google Scholar : PubMed/NCBI

6 

Collina G, Maldarizzi F, Betts CM and Eusebi V: Primary sarcomatoid carcinoma of the adrenal gland. First case report. Virchows Arch A Pathol Anat Histopathol. 415:161–167. 1989. View Article : Google Scholar : PubMed/NCBI

7 

DeLellis RA, Lloyd RV, Heitz PU and Eng C: World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Endocrine Organs. 8:IARC Press. (Lyon, France). 2004.

8 

Tauchmanovà L, Colao A, Marzano LA, Sparano L, Camera L, Rossi A, Palmieri G, Marzano E, Salvatore M, Pettinato G, et al: Andrenocortical carcinomas: Twelve-year prospective experience. World J Surg. 28:896–903. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Okazumi S, Asano T, Ryu M, Nagashima T, Odaka M, Isono K and Nishizawa T: Surgical resection of adrenal carcinoma extending into the vena cava, right atrium and ventricle: Case report and review of the literature. Nihon Geka Gakkai Zasshi. 88:231–238. 1987.(In Japanese). PubMed/NCBI

10 

Decorato JW, Gruber H, Petti M and Levowitz BS: Adrenal carcinosarcoma. J Surg Oncol. 45:134–136. 1990. View Article : Google Scholar : PubMed/NCBI

11 

Fischler DF, Nunez C, Levin HS, McMahon JT, Sheeler LR and Adelstein DJ: Adrenal carcinosarcoma presenting in a woman with clinical signs of virilization. A case report with immunohistochemical and ultrastructural findings. Am J Surg Pathol. 16:626–631. 1992. View Article : Google Scholar : PubMed/NCBI

12 

Barksdale SK, Marincola FM and Jaffe G: Carcinosarcoma of the adrenal cortex presenting with mineralocorticoid excess. Am J Surg Pathol. 17:941–945. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Lee MS, Park IA, Chi JG, Ham EK, Lee KC and Lee CW: Adrenal carcinosarcoma-a case report. J Korean Med Sci. 12:374–377. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Sturm N, Moulai N, Laverrière MH, Chabre O, Descotes JL and Brambilla E: Primary adrenocortical sarcomatoid carcinoma: Case report and review of literature. Virchows Arch. 452:215–219. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Sasaki K, Desimone M, Rao HR, Huang GJ and Seethala RR: Adrenocortical carcinosarcoma: A case report and review of the literature. Diagn Pathol. 5:512010.PubMed/NCBI

16 

Coli A, Di Giorgio A, Castri F, Destito C, Marin AW and Bigotti G: Sarcomatoid carcinoma of the adrenal gland: A case report and review of literature. Pathol Res Pract. 206:59–65. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Yan JJ, Sun AJ, Ren Y and Hou C: Primary adrenocortical sarcomatoid carcinoma: Report of a case. Can Urol Assoc J. 6:E189–E191. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Shaikh AS, Bakhshi GD, Khan AS, Jamadar NM, Nirmala AK and Raza AA: Primary adrenal sarcomatoid carcinoma. Clin Pract. 4:6042014. View Article : Google Scholar : PubMed/NCBI

19 

Fassnacht M, Libé R, Kroiss M and Allolio B: Adrenocortical carcinoma: A clinician's update. Nat Rev Endocrinol. 7:323–335. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Jin Z, Ogata S, Tamura G, Katayama Y, Fukase M, Yajima M and Motoyama T: Carcinosarcomas (malignant mullerian mixed tumors) of the uterus and ovary: A genetic study with special reference to histogenesis. Int J Gynecol Pathol. 22:368–373. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Icard P, Goudet P, Charpenay C, Andreassian B, Carnaille B, Chapuis Y, Cougard P, Henry JF and Proye C: Adrenocortical carcinomas: Surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons study group. World J Surg. 25:891–897. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Hutter AM Jr and Kayhoe DE: Adrenal cortical carcinoma. Clinical features of 138 patients. Am J Med. 41:572–580. 1966. View Article : Google Scholar : PubMed/NCBI

23 

Bourdeau I, MacKenzie-Feder J and Lacroix A: Recent advances in adrenocortical carcinoma in adults. Curr Opin Endocrinol Diabetes Obes. 20:192–197. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Fleming S: Carcinosarcoma (mixed mesodermal tumor) of the ureter. J Urol. 138:1234–1235. 1987.PubMed/NCBI

25 

Beasley MB, Brambilla E and Travis WD: The 2004 World Health Organization classification of lung tumors. Semin Roentgenol. 40:90–97. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Craig JR, Peters RL and Edmondson HA: Tumors of the Liver and Intrahepatic Bile Ducts. Armed Forces Institute of Pathology (Washington, DC). 185–186. 1989.

27 

Koss MN, Hochholzer L and Frommelt RA: Carcinosarcomas of the lung: A clinicopathologic study of 66 patients. Am J Surg Pathol. 23:1514–1526. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Dackiw AP, Lee JE, Gagel RF and Evans DB: Adrenal cortical carcinoma. World J Surg. 25:914–926. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Feng YC, Yang ZG, Chen TW, Su XY, Deng W and Wang QL: Adrenal sarcomatoid carcinoma: A rare case depicted on multi-detector row computed tomography. Indian J Med Sci. 64:37–40. 2010. View Article : Google Scholar : PubMed/NCBI

30 

van't Sant HP, Bouvy ND, Kazemier G, Bonjer HJ, Hop WCJ, Feelders RA, de Herder WW and de Krijger RR: The prognostic value of two different histopathological scoring systems for adrenocortical carcinomas. Histopathology. 51:239–245. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Kendrick ML, Lloyd R, Erickson L, Farley DR, Grant CS, Thompson GB, Rowland C, Young WF Jr and van Heerden JA: Adrenocortical carcinoma: Surgical progress or status quo? Arch Surg. 136:543–549. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Schteingart DE, Doherty GM, Gauger PG, Giordano TJ, Hammer GD, Korobkin M and Worden FP: Management of patients with adrenal cancer: Recommendations of an international consensus conference. Endocr Relat Cancer. 12:667–680. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Terzolo M, Daffara F, Ardito A, Zaggia B, Basile V, Ferrari L and Berruti A: Management of adrenal cancer: A 2013 update. J Endocrinol Invest. 37:207–217. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Kamio T, Shigematsu K, Sou H, Kawai K and Tsuchiyama H: Immunohistochemical expression of epidermal growth factor receptors in human adrenocortical carcinoma. Hum Pathol. 21:277–282. 1990. View Article : Google Scholar : PubMed/NCBI

35 

Wang X, MacLennan GT, Zhang S, Montironi R, Lopez-Beltran A, Tan PH, Foster S, Baldridge LA and Cheng L: Sarcomatoid carcinoma of the upper urinary tract: Clinical outcome and molecular characterization. Hum Pathol. 40:211–217. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Italiano A, Cortot AB, Ilie M, Martel-Planche G, Fabas T, Pop D, Mouroux J, Hofman V, Hofman P and Pedeutour F: EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: Implications for anti-EGFR treatment of a rare lung malignancy. Int J Cancer. 125:2479–2482. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu C, Zheng A, Mao X, Shi B and Li X: Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature. Oncol Lett 11: 3117-3122, 2016.
APA
Zhu, C., Zheng, A., Mao, X., Shi, B., & Li, X. (2016). Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature. Oncology Letters, 11, 3117-3122. https://doi.org/10.3892/ol.2016.4342
MLA
Zhu, C., Zheng, A., Mao, X., Shi, B., Li, X."Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature". Oncology Letters 11.5 (2016): 3117-3122.
Chicago
Zhu, C., Zheng, A., Mao, X., Shi, B., Li, X."Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature". Oncology Letters 11, no. 5 (2016): 3117-3122. https://doi.org/10.3892/ol.2016.4342
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu C, Zheng A, Mao X, Shi B and Li X: Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature. Oncol Lett 11: 3117-3122, 2016.
APA
Zhu, C., Zheng, A., Mao, X., Shi, B., & Li, X. (2016). Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature. Oncology Letters, 11, 3117-3122. https://doi.org/10.3892/ol.2016.4342
MLA
Zhu, C., Zheng, A., Mao, X., Shi, B., Li, X."Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature". Oncology Letters 11.5 (2016): 3117-3122.
Chicago
Zhu, C., Zheng, A., Mao, X., Shi, B., Li, X."Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature". Oncology Letters 11, no. 5 (2016): 3117-3122. https://doi.org/10.3892/ol.2016.4342
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