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Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization

  • Authors:
    • Dongsheng Zhou
    • Jianzhong Liang
    • Li Xu
    • Fengying He
    • Zhongguo Zhou
    • Yaojun Zhang
    • Minshan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2987-2994
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    Published online on: March 21, 2016
       https://doi.org/10.3892/ol.2016.4359
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Abstract

The derived neutrophil to lymphocyte ratio (dNLR) has been proposed as an easily determinable prognostic factor for cancer patients, but the prognostic significance of the dNLR in hepatocellular carcinoma (HCC) has not been investigated. The present study aimed to validate the prognostic power of the NLR and dNLR in HCC patients undergoing transarterial chemoembolization (TACE). The data of 279 consecutive patients who underwent TACE for unresectable HBV‑associated HCC between September 2009 and November 2011 at the Department of Hepatobiliary Surgery, Sun Yat‑sen University Cancer Center (Guangzhou, China) were retrieved from a prospective database. The cut‑off values for the NLR and dNLR were determined by receiver operating characteristic (ROC) analysis. The association between the NLR and dNLR and the clinicopathological characteristics and overall survival (OS) rates and times of patients was analyzed. The area under the curve (AUC) was calculated to evaluate the discriminatory ability of the NLR and dNLR. The median follow‑up period was 446 days, the 1, 2 and 3‑year OS rates were 38.8, 18.5 and 11.1% respectively, and the median OS time was 264 days. The cut‑off values were determined as 2.6 and 1.8 for the NLR and dNLR, respectively. The NLR and dNLR were each associated with patient age, presence of vascular invasion, tumor size, AST level and ALP level. Multivariate analysis showed that the NLR, dNLR, ALT level and AFP level were independent prognostic factors for OS. An elevated NLR or dNLR was associated with a poor prognosis (P=0.001 and P=0.002, respectively). The prognostic power of NLR [AUC=0.539; 95% confidence interval (CI), 0.423‑0.656] and dNLR (AUC=0.522; 95% CI, 0.406‑0.638) was similar. Elevated dNLR predicted poor prognosis for patients with HBV‑associated HCC undergoing TACE, with similar prognostic power to NLR. The dNLR may be used as an alternative to the NLR, as it is easily available and inexpensive.
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1 

Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 24:2137–2150. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Farazi PA and DePinho RA: Hepatocellular carcinoma pathogenesis: From genes to environment. Nat Rev Cancer. 6:674–687. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Chalasani N, Horlander JC Sr, Said A, Hoen H, Kopecky KK, Stockberger SM Jr, Manam R, Kwo PY and Lumeng L: Screening for hepatocellular carcinoma in patients with advanced cirrhosis. Am J Gastroenterol. 94:2988–2993. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Tsukuma H, Hiyama T, Tanaka S, Nakao M, Yabuuchi T, Kitamura T, Nakanishi K, Fujimoto I, Inoue A, Yamazaki H, et al: Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med. 328:1797–1801. 1993. View Article : Google Scholar : PubMed/NCBI

5 

Saraswat VA, Pandey G and Shetty S: Treatment algorithms for managing hepatocellular carcinoma. J Clin Exp Hepatol. 4:S80–S89. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Llovet JM, Burroughs A and Bruix J: Hepatocellular carcinoma. Lancet. 362:1907–1917. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Llovet JM and Bruix J: Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology. 37:429–442. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Colotta F, Allavena P, Sica A, Garlanda C and Mantovani A: Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability. Carcinogenesis. 30:1073–1081. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Forrest LM, McMillan DC, McArdle CS, Angerson WJ, Dagg K and Scott HR: A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer. Br J Cancer. 92:1834–1836. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Hashimoto K, Ikeda Y, Korenaga D, Tanoue K, Hamatake M, Kawasaki K, Yamaoka T, Iwatani Y, Akazawa K and Takenaka K: The impact of preoperative serum C-reactive protein on the prognosis of patients with hepatocellular carcinoma. Cancer. 103:1856–1864. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Ishizuka M, Kubota K, Kita J, Shimoda M, Kato M and Sawada T: Usefulness of a modified inflammation-based prognostic system for predicting postoperative mortality of patients undergoing surgery for primary hepatocellular carcinoma. J Surg Oncol. 103:801–806. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Fushiya N, Koike K, Nishino H and Tajiri H: Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma. Br J Cancer. 107:988–993. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Gomez D, Farid S, Malik HZ, Young AL, Toogood GJ, Lodge JP and Prasad KR: Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg. 32:1757–1762. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Halazun KJ, Hardy MA, Rana AA, Woodland DC IV, Luyten EJ, Mahadev S, Witkowski P, Siegel AB, Brown RS Jr and Emond JC: Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg. 250:141–151. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Huang ZL, Luo J, Chen MS, Li JQ and Shi M: Blood neutrophil-to-lymphocyte ratio predicts survival in patients with unresectable hepatocellular carcinoma undergoing transarterial chemoembolization. J Vasc Interv Radiol. 22:702–709. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Chen TM, Lin CC, Huang PT and Wen CF: Neutrophil-to-lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation. J Gastroenterol Hepatol. 27:553–561. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Pinato DJ, North BV and Sharma R: A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: The prognostic nutritional index (PNI). Br J Cancer. 106:1439–1445. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R and Small D: The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer. Curr Oncol. 17:52–58. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Smith RA, Bosonnet L, Raraty M, Sutton R, Neoptolemos JP, Campbell F and Ghaneh P: Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma. Am J Surg. 197:466–472. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Proctor MJ, McMillan DC, Morrison DS, Fletcher CD, Horgan PG and Clarke SJ: A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer. Br J Cancer. 107:695–699. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Kusumanto YH, Dam WA, Hospers GA, Meijer C and Mulder NH: Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis. 6:283–287. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Chen MS, Li JQ, Zhang YQ, Lu LX, Zhang WZ, Yuan YF, Guo YP, Lin XJ and Li GH: High-dose iodized oil transcatheter arterial chemoembolization for patients with large hepatocellular carcinoma. World J Gastroenterol. 8:74–78. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Proctor MJ, Morrison DS, Talwar D, Balmer SM, Fletcher CD, O'Reilly DS, Foulis AK, Horgan PG and McMillan DC: A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer. 47:2633–2641. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Dan J, Zhang Y, Peng Z, Huang J, Gao H, Xu L and Chen M: Postoperative neutrophil-to-lymphocyte ratio change predicts survival of patients with small hepatocellular carcinoma undergoing radiofrequency ablation. PloS One. 8:e581842013. View Article : Google Scholar : PubMed/NCBI

26 

Mantovani A, Allavena P, Sica A and Balkwill F: Cancer-related inflammation. Nature. 454:436–444. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Ulich TR, del Castillo J, Keys M, Granger GA and Ni RX: Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes. J Immunol. 139:3406–3415. 1987.PubMed/NCBI

29 

Ulich TR, del Castillo J and Guo KZ: In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs. Blood. 73:108–110. 1989.PubMed/NCBI

30 

Teramukai S, Kitano T, Kishida Y, Kawahara M, Kubota K, Komuta K, Minato K, Mio T, Fujita Y, Yonei T, et al: Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: An analysis of Japan multinational trial organisation LC00-03. Eur J Cancer. 45:1950–1958. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation and cancer. Cell. 140:883–899. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Dunn GP, Old LJ and Schreiber RD: The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 21:137–148. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Dunn GP, Ikeda H, Bruce AT, Koebel C, Uppaluri R, Bui J, Chan R, Diamond M, White JM, Sheehan KC and Schreiber RD: Interferon-gamma and cancer immunoediting. Immunol Res. 32:231–245. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Rabinowich H, Cohen R, Bruderman I, Steiner Z and Klajman A: Functional analysis of mononuclear cells infiltrating into tumors: Lysis of autologous human tumor cells by cultured infiltrating lymphocytes. Cancer Res. 47:173–177. 1987.PubMed/NCBI

35 

Hoffmann TK, Dworacki G, Tsukihiro T, Meidenbauer N, Gooding W, Johnson JT and Whiteside TL: Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance. Clin Cancer Res. 8:2553–2562. 2002.PubMed/NCBI

36 

Schmidt H, Bastholt L, Geertsen P, Christensen IJ, Larsen S, Gehl J and von der Maase H: Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: A prognostic model. Br J Cancer. 93:273–278. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Cho H and Kim JH: Multiplication of neutrophil and monocyte counts (MNM) as an easily obtainable tumour marker for cervical cancer. Biomarkers. 14:161–170. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Millrud CR, Kvarnhammar Månsson A, Uddman R, Björnsson S, Riesbeck K and Cardell LO: The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival. PloS One. 7:e511202012. View Article : Google Scholar : PubMed/NCBI

39 

Leitch EF, Chakrabarti M, Crozier JE, McKee RF, Anderson JH, Horgan PG and McMillan DC: Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer. Br J Cancer. 97:1266–1270. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Hernaez R, Yeh HC, Lazo M, Chung HM, Hamilton JP, Koteish A, Potter JJ, Brancati FL and Clark JM: Elevated ALT and GGT predict all-cause mortality and hepatocellular carcinoma in Taiwanese male: A case-cohort study. Hepatol Int. 7:1040–1049. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Tarao K, Rino Y, Takemiya S, Tamai S, Ohkawa S, Sugimasa Y, Miyakawa K, Morinaga S, Yoshida M, Shibuya A, et al: Close association between high serum ALT and more rapid recurrence of hepatocellular carcinoma in hepatectomized patients with HCV-associated liver cirrhosis and hepatocellular carcinoma. Intervirology. 43:20–26. 2000. View Article : Google Scholar : PubMed/NCBI

42 

El-Serag HB, Kramer JR, Chen GJ, Duan Z, Richardson PA and Davila JA: Effectiveness of AFP and ultrasound tests on hepatocellular carcinoma mortality in HCV-infected patients in the USA. Gut. 60:992–997. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Giannini E, Botta F, Fasoli A, Ceppa P, Risso D, Lantieri PB, Celle G and Testa R: Progressive liver functional impairment is associated with an increase in AST/ALT ratio. Dig Dis Sci. 44:1249–1253. 1999. View Article : Google Scholar : PubMed/NCBI

44 

Giannini E, Risso D, Botta F, Chiarbonello B, Fasoli A, Malfatti F, Romagnoli P, Testa E, Ceppa P and Testa R: Validity and clinical utility of the aspartate aminotransferase-alanine aminotransferase ratio in assessing disease severity and prognosis in patients with hepatitis C virus-related chronic liver disease. Arch Intern Med. 163:218–224. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Carr BI, Guerra V, Giannini EG, Farinati F, Ciccarese F, Rapaccini GL, Di Marco M, Benvegnù L, Zoli M, Borzio F, et al: Significance of platelet and AFP levels and liver function parameters for HCC size and survival. Int J Biol Markers. 29:e215–e223. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou D, Liang J, Xu L, He F, Zhou Z, Zhang Y and Chen M: Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization. Oncol Lett 11: 2987-2994, 2016.
APA
Zhou, D., Liang, J., Xu, L., He, F., Zhou, Z., Zhang, Y., & Chen, M. (2016). Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization. Oncology Letters, 11, 2987-2994. https://doi.org/10.3892/ol.2016.4359
MLA
Zhou, D., Liang, J., Xu, L., He, F., Zhou, Z., Zhang, Y., Chen, M."Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization". Oncology Letters 11.5 (2016): 2987-2994.
Chicago
Zhou, D., Liang, J., Xu, L., He, F., Zhou, Z., Zhang, Y., Chen, M."Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization". Oncology Letters 11, no. 5 (2016): 2987-2994. https://doi.org/10.3892/ol.2016.4359
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou D, Liang J, Xu L, He F, Zhou Z, Zhang Y and Chen M: Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization. Oncol Lett 11: 2987-2994, 2016.
APA
Zhou, D., Liang, J., Xu, L., He, F., Zhou, Z., Zhang, Y., & Chen, M. (2016). Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization. Oncology Letters, 11, 2987-2994. https://doi.org/10.3892/ol.2016.4359
MLA
Zhou, D., Liang, J., Xu, L., He, F., Zhou, Z., Zhang, Y., Chen, M."Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization". Oncology Letters 11.5 (2016): 2987-2994.
Chicago
Zhou, D., Liang, J., Xu, L., He, F., Zhou, Z., Zhang, Y., Chen, M."Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization". Oncology Letters 11, no. 5 (2016): 2987-2994. https://doi.org/10.3892/ol.2016.4359
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