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Case Report

Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review

  • Authors:
    • Yang Yang
    • Jingyi Fang
    • Da Li
    • Liang Wang
    • Nan Ji
    • Junting Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China, Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, P.R. China
  • Pages: 3395-3402
    |
    Published online on: March 29, 2016
       https://doi.org/10.3892/ol.2016.4386
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Abstract

Neurenteric cysts (NCs) are uncommon congenital cystic lesions. Malignantly transformed NCs are extremely rare. The present study reports the case of a recurrent foramen magnum NC with a malignant transformation and reviews 8 previously reported cases. A 58‑year‑old woman with a 5‑month history of occasional headaches, dizziness and vomiting presented to the Beijing Tiantan Hospital (Beijing, China) with palsy of the left cranial IX and X nerves, decreased sensation in the limbs on the right side and an ataxic gait. Magnetic resonance imaging (MRI) scans revealed a cystic mass in the left side of the foramen magnum, positioned anteriolaterally to the medulla oblongata. Surgery using a left suboccipital retrosigmoid approach was performed. The lesion was partially resected and was histopathologically diagnosed as an NC with focal hyperplasia of the epithelial cells. Additional MRI scans that were performed 25 months later revealed a solid lesion posterior to the medullar oblongata. Therefore, surgery using a suboccipital midline approach was performed. The solid lesion was sub‑totally removed and was histopathologically diagnosed as a well‑differentiated papillary adenocarcinoma. At 1 month post‑surgery, the patient's condition worsened, eventually resulting in mortality due to respiratory failure. Based on the findings of the present case and previous literature, strict criteria for malignant‑transformed NCs were created. The location distribution of malignant‑transformed NCs does not coincide with the location distribution of all NCs, and malignantly transformed NCs usually occur in adult patients and present as atypical radiological features. Surgery is the optimal treatment for malignantly transformed NCs, and the effectiveness of adjuvant therapy requires additional studies.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Fang J, Li D, Wang L, Ji N and Zhang J: Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review. Oncol Lett 11: 3395-3402, 2016.
APA
Yang, Y., Fang, J., Li, D., Wang, L., Ji, N., & Zhang, J. (2016). Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review. Oncology Letters, 11, 3395-3402. https://doi.org/10.3892/ol.2016.4386
MLA
Yang, Y., Fang, J., Li, D., Wang, L., Ji, N., Zhang, J."Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review". Oncology Letters 11.5 (2016): 3395-3402.
Chicago
Yang, Y., Fang, J., Li, D., Wang, L., Ji, N., Zhang, J."Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review". Oncology Letters 11, no. 5 (2016): 3395-3402. https://doi.org/10.3892/ol.2016.4386
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Fang J, Li D, Wang L, Ji N and Zhang J: Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review. Oncol Lett 11: 3395-3402, 2016.
APA
Yang, Y., Fang, J., Li, D., Wang, L., Ji, N., & Zhang, J. (2016). Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review. Oncology Letters, 11, 3395-3402. https://doi.org/10.3892/ol.2016.4386
MLA
Yang, Y., Fang, J., Li, D., Wang, L., Ji, N., Zhang, J."Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review". Oncology Letters 11.5 (2016): 3395-3402.
Chicago
Yang, Y., Fang, J., Li, D., Wang, L., Ji, N., Zhang, J."Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review". Oncology Letters 11, no. 5 (2016): 3395-3402. https://doi.org/10.3892/ol.2016.4386
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