Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer (Review)

  • Authors:
    • Qiao Peng
    • Hui Chen
    • Ji‑Rong Huo
  • View Affiliations

  • Published online on: April 1, 2016     https://doi.org/10.3892/ol.2016.4401
  • Pages: 3231-3239
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Esophageal cancer is the eighth most common type of cancer in the world, and the sixth most common cause of mortality from cancer. Alcohol consumption is the major risk factor for esophageal cancer, due to the worldwide prevalence and high carcinogenicity of the ethanol metabolite. In epidemiological studies, the efficiency of alcohol intake to enhance the risk of esophageal cancer is altered by daily ethanol consumption, type of alcoholic beverages ingested, time since quitting drinking, age of drinking initiation, differences in population and subtypes of esophageal cancer. Corresponding factors, including gene polymorphisms, tobacco smoking, oral microorganisms and folate deficiency, reveal a synergistic effect in concurrent alcohol users that may lead to an increased risk of developing esophageal cancer. Consequently, esophageal cancer prevention involves multiple aspects, including quitting drinking and smoking, maintaining an adequate oral health and ingesting adequate quantities of folate, particularly in genetically high‑risk populations.
View Figures
View References

Related Articles

Journal Cover

May-2016
Volume 11 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Peng Q, Chen H and Huo JR: Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer (Review). Oncol Lett 11: 3231-3239, 2016
APA
Peng, Q., Chen, H., & Huo, J. (2016). Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer (Review). Oncology Letters, 11, 3231-3239. https://doi.org/10.3892/ol.2016.4401
MLA
Peng, Q., Chen, H., Huo, J."Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer (Review)". Oncology Letters 11.5 (2016): 3231-3239.
Chicago
Peng, Q., Chen, H., Huo, J."Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer (Review)". Oncology Letters 11, no. 5 (2016): 3231-3239. https://doi.org/10.3892/ol.2016.4401