Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma

  • Authors:
    • Shintaro Kawano
    • Yanqun Zheng
    • Kazunari Oobu
    • Ryota Matsubara
    • Yuichi Goto
    • Toru Chikui
    • Tadamasa Yoshitake
    • Tamotsu Kiyoshima
    • Teppei Jinno
    • Yasuyuki Maruse
    • Eiji Mitate
    • Ryoji Kitamura
    • Hideaki Tanaka
    • Takeshi Toyoshima
    • Tsuyoshi Sugiura
    • Seiji Nakamura
  • View Affiliations

  • Published online on: April 5, 2016     https://doi.org/10.3892/ol.2016.4411
  • Pages: 3369-3376
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Abstract

The administration of pre-operative chemotherapy with S‑1 and concurrent radiotherapy at a total dose of 30 Gy was clinicopathologically evaluated as a treatment for locally advanced oral squamous cell carcinoma (OSCC) in the present study. The participants comprised 81 patients with OSCC, consisting of 29 patients with stage II disease, 12 patients with stage III disease and 40 patients with stage IV disease. All patients received a total radiation dose of 30 Gy in daily fractions of 2 Gy, 5 times a week, for 3 weeks, and the patients were concurrently administered S‑1 at a dose of 80‑120 mg, twice daily, over 4 consecutive weeks. Radical surgery was performed in all cases at 2‑6 weeks subsequent to the end of pre‑operative chemoradiotherapy. The most common adverse event was oropharyngeal mucositis, but this was transient in all patients. No severe hematological or non‑hematological toxicities were observed. The clinical and histopathological response rates were 70.4 and 75.3%, respectively. Post‑operatively, local failure developed in 6 patients (7.4%) and neck failure developed in 2 patients (2.5%). Distant metastases were found in 7 patients (8.6%). The overall survival rate, disease‑specific survival rate and locoregional control rate at 5 years were 87.7, 89.9 and 90.6%, respectively. Locoregional recurrence occurred more frequently in patients that demonstrated a poor histopathological response compared with patients that demonstrated a good response (P<0.01). These results indicate that pre-operative S-1 chemotherapy with radiotherapy at a total dose of 30 Gy is feasible and effective for patients with locally advanced OSCC, and that little or no histopathological response may be a risk factor for locoregional recurrence in this treatment.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kawano S, Zheng Y, Oobu K, Matsubara R, Goto Y, Chikui T, Yoshitake T, Kiyoshima T, Jinno T, Maruse Y, Maruse Y, et al: Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma. Oncol Lett 11: 3369-3376, 2016
APA
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T. ... Nakamura, S. (2016). Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma. Oncology Letters, 11, 3369-3376. https://doi.org/10.3892/ol.2016.4411
MLA
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T., Yoshitake, T., Kiyoshima, T., Jinno, T., Maruse, Y., Mitate, E., Kitamura, R., Tanaka, H., Toyoshima, T., Sugiura, T., Nakamura, S."Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma". Oncology Letters 11.5 (2016): 3369-3376.
Chicago
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T., Yoshitake, T., Kiyoshima, T., Jinno, T., Maruse, Y., Mitate, E., Kitamura, R., Tanaka, H., Toyoshima, T., Sugiura, T., Nakamura, S."Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma". Oncology Letters 11, no. 5 (2016): 3369-3376. https://doi.org/10.3892/ol.2016.4411