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Article

Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma

  • Authors:
    • Shintaro Kawano
    • Yanqun Zheng
    • Kazunari Oobu
    • Ryota Matsubara
    • Yuichi Goto
    • Toru Chikui
    • Tadamasa Yoshitake
    • Tamotsu Kiyoshima
    • Teppei Jinno
    • Yasuyuki Maruse
    • Eiji Mitate
    • Ryoji Kitamura
    • Hideaki Tanaka
    • Takeshi Toyoshima
    • Tsuyoshi Sugiura
    • Seiji Nakamura
  • View Affiliations / Copyright

    Affiliations: Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Fukuoka 812‑8582, Japan, Section of Oral and Maxillofacial Radiology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Fukuoka 812‑8582, Japan, Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812‑8582, Japan, Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Fukuoka 812‑8582, Japan
  • Pages: 3369-3376
    |
    Published online on: April 5, 2016
       https://doi.org/10.3892/ol.2016.4411
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Abstract

The administration of pre-operative chemotherapy with S‑1 and concurrent radiotherapy at a total dose of 30 Gy was clinicopathologically evaluated as a treatment for locally advanced oral squamous cell carcinoma (OSCC) in the present study. The participants comprised 81 patients with OSCC, consisting of 29 patients with stage II disease, 12 patients with stage III disease and 40 patients with stage IV disease. All patients received a total radiation dose of 30 Gy in daily fractions of 2 Gy, 5 times a week, for 3 weeks, and the patients were concurrently administered S‑1 at a dose of 80‑120 mg, twice daily, over 4 consecutive weeks. Radical surgery was performed in all cases at 2‑6 weeks subsequent to the end of pre‑operative chemoradiotherapy. The most common adverse event was oropharyngeal mucositis, but this was transient in all patients. No severe hematological or non‑hematological toxicities were observed. The clinical and histopathological response rates were 70.4 and 75.3%, respectively. Post‑operatively, local failure developed in 6 patients (7.4%) and neck failure developed in 2 patients (2.5%). Distant metastases were found in 7 patients (8.6%). The overall survival rate, disease‑specific survival rate and locoregional control rate at 5 years were 87.7, 89.9 and 90.6%, respectively. Locoregional recurrence occurred more frequently in patients that demonstrated a poor histopathological response compared with patients that demonstrated a good response (P<0.01). These results indicate that pre-operative S-1 chemotherapy with radiotherapy at a total dose of 30 Gy is feasible and effective for patients with locally advanced OSCC, and that little or no histopathological response may be a risk factor for locoregional recurrence in this treatment.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Funk GF, Karnell LH, Robinson RA, Zhen WK, Trask DK and Hoffman HT: Presentation, treatment and outcome of oral cavity cancer: A national cancer data base report. Head Neck. 24:165–180. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Gowen GF and Desuto-Nagy G: The incidence and sites of distant metastases in head and neck carcinoma. Surg Gynecol Obstet. 116:603–607. 1963.PubMed/NCBI

4 

Fletcher GH and Evers WT: Radiotherapeutic management of surgical recurrences and postoperative residuals in tumors of the head and neck. Radiology. 95:185–188. 1970. View Article : Google Scholar : PubMed/NCBI

5 

Cohen EE, Lingen MW and Vokes EE: The expanding role of systemic therapy in head and neck cancer. J Clin Oncol. 22:1743–1752. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Kirita T, Ohgi K, Shimooka H, Yamanaka Y, Tatebayashi S, Yamamoto K, Mishima K and Sugimura M: Preoperative concurrent chemoradiotherapy plus radical surgery for advanced squamous cell carcinoma of the oral cavity: An analysis of long-term results. Oral Oncol. 35:597–606. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Freier K, Engel M, Lindel K, Flechtenmacher C, Mühling J, Hassfeld S and Hofele C: Neoadjuvant concurrent radiochemotherapy followed by surgery in advanced oral squamous cell carcinoma (OSCC): A retrospective analysis of 207 patients. Oral Oncol. 44:116–123. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Mohr C, Bohndorf W, Carstens J, Härle F, Hausamen JE, Hirche H, Kimmig H, Kutzner J, Mühling J and Reuther J: Preoperative radiochemotherapy and radical surgery in comparison with radical surgery alone. A prospective, multicentric, randomized DOSAK study of advanced squamous cell carcinoma of the oral cavity and the oropharynx (a 3-year follow-up). Int J Oral Maxillofac Surg. 23:140–148. 1994. View Article : Google Scholar : PubMed/NCBI

9 

Klug C, Berzaczy D, Voracek M and Millesi W: Preoperative chemoradiotherapy in the management of oral cancer: A review. J Craniomaxillofac Surg. 36:75–88. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Kirita T, Yamanaka Y, Imai Y, Yamakawa N, Aoki K, Nakagawa Y, Yagyuu T and Hasegawa M: Preoperative concurrent chemoradiotherapy for stages II–IV oral squamous cell carcinoma: A retrospective analysis and the future possibility of this treatment strategy. Int J Oral Maxillofac Surg. 41:421–428. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Shirasaka T, Shimamoto Y, Ohshimo H, Yamaguchi M, Kato T, Yonekura K and Fukushima M: Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs. 7:548–557. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Harada K, Kawaguchi S, Supriatno S, Onoue T, Yoshida Ha and Sato M: Combined effects of the oral fluoropyrimidine anticancer agent, S-1 and radiation on human oral cancer cells. Oral Oncol. 40:713–719. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Harada H and Omura K: Preoperative concurrent chemotherapy with S-1 and radiotherapy for locally advanced squamous cell carcinoma of the oral cavity: Phase I trial. J Exp Clin Cancer Res. 29:332010. View Article : Google Scholar : PubMed/NCBI

14 

National Cancer Institute: Common Terminology Criteria for Adverse Events v4.0 (CTCAE). http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdfAccessed. March 08–2016

15 

Sobin LH and Wittekind C: TNM classification of malignant tumours (6th). Wiley-Liss, Inc. New York: 2002.

16 

Yuasa K, Kawazu T, Nagata T, Kanda S, Ohishi M and Shirasuna K: Computed tomography and ultrasonography of metastatic cervical lymph nodes in oral squamous cell carcinoma. Dentomaxillofac Radiol. 29:238–244. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Yuasa K, Kawazu T, Kunitake N, Uehara S, Omagari J, Yoshiura K, Nakayama E and Kanda S: Sonography for the detection of cervical lymph node metastases among patients with tongue cancer: Criteria for early detection and assessment of follow-up examination intervals. Am J Neuroradiol. 21:1127–1132. 2000.PubMed/NCBI

18 

Gale N, Pilch BZ, Sindransky D, El Naggar A, Westra W, Califano J, Johnson N and MacDonald DG: Epithelial precursor lesions. In: World Health Organization Classification of Tumors. Pathology and Genetics of Head and Neck Tumors. Barnes L, Eveson JW, Reichart P and Sidransky D: IARC Press. (Lyon). 177–179. 2005.

19 

Yamamoto E, Miyakawa A and Kohama G: Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity. Head Neck Surg. 6:938–947. 1984. View Article : Google Scholar : PubMed/NCBI

20 

Eisenhauera EA, Therasseb P, Bogaertsc J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S and Mooney M: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Shimosato Y, Oboshi S and Baba K: Histological evaluation of effects of radiotherapy and chemotherapy for carcinomas. Jpn J Clin Oncol. 1:19–35. 1971.

22 

Slotman GJ, Doolittle CH and Glicksman AS: Preoperative combined chemotherapy and radiation therapy plus radical surgery in advanced head and neck cancer. Five-year results with impressive complete response rates and high survival. Cancer. 69:2736–2743. 1992. View Article : Google Scholar : PubMed/NCBI

23 

Giralt JL, Gonzalez J, del Campo JM, Maldonado J, Sanz X, Pamias J, Eraso A, Bescos S and Raspall G: Preoperative induction chemotherapy followed by concurrent chemoradiotherapy in advanced carcinoma of the oral cavity and oropharynx. Cancer. 89:939–945. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Mücke T, Konen M, Wagenpfeil S, Kesting MR, Wolff KD and Hölzle F: Low-dose preoperative chemoradiation therapy compared with surgery alone with or without postoperative radiotherapy in patients with head and neck carcinoma. Ann Surg Oncol. 18:2739–2747. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Iguchi H, Kusuki M, Nakamura A, Nishiura H, Kanazawa A, Takayama M, Sunami K and Yamane H: Concurrent chemoradiotherapy with pirarubicin and 5-fluorouracil for resectable oral and maxillary carcinoma. Acta Otolaryngol Suppl. 554:55–61. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Numico G, Benasso M, Vannozzi MO, Merlano M, Rosso R, Viale M and Esposito M: Hydration regimen and hematological toxicity of a cisplatin-based chemotherapy regimen. Clinical observations and pharmacokinetic analysis. Anticancer Res. 18:1313–1318. 1998.PubMed/NCBI

27 

Harada H, Omura K, Tomioka H, Nakayama H, Hiraki A, Shinohara M, Yoshihama Y and Shintani S: Multicenter phase II trial of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma. Cancer Chemother Pharmacol. 71:1059–1064. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Tsukuda M, Ishitoya J, Mikami Y, Matsuda H, Horiuchi C, Taguchi T, Satake K, Kawano T, Takahashi M and Nishimura G: Analysis of feasibility and toxicity of concurrent chemoradiotherapy with S-1 for locally advanced squamous cell carcinoma of the head and neck in elderly and/or cases with comorbidity. Cancer Chemother Pharmacol. 64:945–952. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Tsukuda M, Kida A, Fujii M, Kono N, Yoshihara T, Hasegawa Y and Sugita M: Chemotherapy Study Group of Head and Neck Cancer: Randomized scheduling feasibility study of S-1 for adjuvant chemotherapy in advanced head and neck cancer. Br J Cancer. 93:884–889. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Miyawaki A, Hijioka H, Ikeda R, Ishida T, Nozoe E and Nakamura N: Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma. Oncol Lett. 3:995–1001. 2012.PubMed/NCBI

31 

Nomura T, Murakami R, Toya R, Teshima K, Nakahara A, Hirai T, Hiraki A, Nakayama H, Yoshitake Y and Ota K: Phase II study of preoperative concurrent chemoradiation therapy with S-1 in patients with T4 oral squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 76:1347–1352. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Bernier J, Domenge C, Ozashin M, Matuszewska K, Lefèbvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, et al: Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 350:1945–1952. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Pignon JP, Bourhis J, Domenge C and Designé L: Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data. MACH-NC collaborative group. Meta-analysis of chemotherapy on head and neck cancer. Lancet. 355:949–955. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Licitra L, Grandi C, Guzzo M, Mariani L, Lo Vullo S, Valvo F, Quattrone P, Valagussa P, Bonadonna G, Molinari R and Cantù G: Primary chemotherapy in resectable oral cavity squamous cell cancer: A randomized controlled trial. J Clin Oncol. 21:327–333. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Yanamoto S, Yamada S, Takahashi H, Yoshitomi I, Kawasaki G, Ikeda H, Minamizato T, Shiraishi T, Fujita S and Ikeda T: Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma. Int J oral Maxillofac Surg. 41:1195–1200. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kawano S, Zheng Y, Oobu K, Matsubara R, Goto Y, Chikui T, Yoshitake T, Kiyoshima T, Jinno T, Maruse Y, Maruse Y, et al: Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma. Oncol Lett 11: 3369-3376, 2016.
APA
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T. ... Nakamura, S. (2016). Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma. Oncology Letters, 11, 3369-3376. https://doi.org/10.3892/ol.2016.4411
MLA
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T., Yoshitake, T., Kiyoshima, T., Jinno, T., Maruse, Y., Mitate, E., Kitamura, R., Tanaka, H., Toyoshima, T., Sugiura, T., Nakamura, S."Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma". Oncology Letters 11.5 (2016): 3369-3376.
Chicago
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T., Yoshitake, T., Kiyoshima, T., Jinno, T., Maruse, Y., Mitate, E., Kitamura, R., Tanaka, H., Toyoshima, T., Sugiura, T., Nakamura, S."Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma". Oncology Letters 11, no. 5 (2016): 3369-3376. https://doi.org/10.3892/ol.2016.4411
Copy and paste a formatted citation
x
Spandidos Publications style
Kawano S, Zheng Y, Oobu K, Matsubara R, Goto Y, Chikui T, Yoshitake T, Kiyoshima T, Jinno T, Maruse Y, Maruse Y, et al: Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma. Oncol Lett 11: 3369-3376, 2016.
APA
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T. ... Nakamura, S. (2016). Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma. Oncology Letters, 11, 3369-3376. https://doi.org/10.3892/ol.2016.4411
MLA
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T., Yoshitake, T., Kiyoshima, T., Jinno, T., Maruse, Y., Mitate, E., Kitamura, R., Tanaka, H., Toyoshima, T., Sugiura, T., Nakamura, S."Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma". Oncology Letters 11.5 (2016): 3369-3376.
Chicago
Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T., Yoshitake, T., Kiyoshima, T., Jinno, T., Maruse, Y., Mitate, E., Kitamura, R., Tanaka, H., Toyoshima, T., Sugiura, T., Nakamura, S."Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma". Oncology Letters 11, no. 5 (2016): 3369-3376. https://doi.org/10.3892/ol.2016.4411
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