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Article

Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer

  • Authors:
    • Yunqin Liu
    • Jinming Yu
    • Liting Qian
    • Hongyan Zhang
    • Jun Ma
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Shandong Tumor Hospital, Shandong Medical University, Jinan, Shandong 250117, P.R. China, Department of Radiation Oncology, Anhui Cancer Hospital, Anhui Medical University, Hefei, Anhui 230001, P.R. China
  • Pages: 3421-3427
    |
    Published online on: April 6, 2016
       https://doi.org/10.3892/ol.2016.4416
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Abstract

The present study assessed the efficacy and toxicity of definitive extended-field intensity-modulated radiotherapy (EF-IMRT) plus concurrent chemotherapy in cervical cancer. A total of 48 patients with cervical cancer received the planning target volume between 39.6 and 50.4 Gy in 1.8‑2.0 Gy daily fractions, while the enlarged pelvic and/or para‑aortic nodes were treated with a total dose of 55‑60 Gy in 2.0‑2.4 Gy daily fractions using simultaneous integrated boost‑IMRT. All patients underwent high dose‑rate brachytherapy. Concurrent to EF‑IMRT, nedaplatin was administered weekly at a median dose of 30 mg/m2 (range, 25‑40 mg/m2) for 5 weeks with a total of 150 mg/m2. Of the 48 patients, 46 patients exhibited initial complete responses and 2 patients had partial responses, with a response rate of 100%. After 4‑24 months of treatment, 12 patients (27.08%) had local and/or distant failure and 39 patients (81.25%) were alive at the last follow‑up. The 12-month overall survival (OS) and disease‑free survival (DFS) were 87.5 and 75.8%, respectively, while the 24‑month OS and DFS were 69.7 and 49.7%, respectively. Grade ≥3 acute neutropenia and thrombcytopenia occurred in 20 (41.7%) and 4 (8.3%) patients, respectively, while 2 patients (4.2%) developed grade ≥3 diarrhea and 2 (4.2%) had grade ≥3 late toxicities. However, no patients exhibited grade ≥3 vomiting. Thus, concurrent nedaplatin chemotherapy with definitive EF‑IMRT was effective and relatively safe for treating patients with cervical cancer. Furthermore, EF-IMRT was able to deliver ≤60 Gy to enlarged para-aortic and/or pelvic nodes using simultaneous integrated boost without increased acute and late gastrointestinal toxicity.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Yu J, Qian L, Zhang H and Ma J: Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer. Oncol Lett 11: 3421-3427, 2016.
APA
Liu, Y., Yu, J., Qian, L., Zhang, H., & Ma, J. (2016). Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer. Oncology Letters, 11, 3421-3427. https://doi.org/10.3892/ol.2016.4416
MLA
Liu, Y., Yu, J., Qian, L., Zhang, H., Ma, J."Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer". Oncology Letters 11.5 (2016): 3421-3427.
Chicago
Liu, Y., Yu, J., Qian, L., Zhang, H., Ma, J."Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer". Oncology Letters 11, no. 5 (2016): 3421-3427. https://doi.org/10.3892/ol.2016.4416
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Yu J, Qian L, Zhang H and Ma J: Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer. Oncol Lett 11: 3421-3427, 2016.
APA
Liu, Y., Yu, J., Qian, L., Zhang, H., & Ma, J. (2016). Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer. Oncology Letters, 11, 3421-3427. https://doi.org/10.3892/ol.2016.4416
MLA
Liu, Y., Yu, J., Qian, L., Zhang, H., Ma, J."Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer". Oncology Letters 11.5 (2016): 3421-3427.
Chicago
Liu, Y., Yu, J., Qian, L., Zhang, H., Ma, J."Extended field intensity-modulated radiotherapy plus concurrent nedaplatin treatment in cervical cancer". Oncology Letters 11, no. 5 (2016): 3421-3427. https://doi.org/10.3892/ol.2016.4416
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