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Article

Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity

  • Authors:
    • Ya‑Di Wang
    • Su‑Xian Chen
    • Li‑Qun Ren
  • View Affiliations / Copyright

    Affiliations: Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pathology, The Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121000, P.R. China
  • Pages: 3483-3492
    |
    Published online on: April 7, 2016
       https://doi.org/10.3892/ol.2016.4424
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Abstract

Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta‑analysis examined the association between serum BNP levels and AIC by using data from high quality studies published in peer‑reviewed journals. Relevant studies were identified through literature searches of China National Knowledge Infrastructure (CNKI), Web of Science, PubMed, Google Scolar and China BioMedicine (CBM). STATA software was used in this meta‑analysis for statistical analysis. In addition, the crude standardized mean difference (SMD) with 95% confidence interval (CI) for the highest vs. the lowest category of serum BNP levels was calculated. A total of 8 independent case‑control studies, containing 126 AIC patients and 569 healthy controls, were included for the current meta‑analysis. The results indicated a significant difference in serum BNP levels between the cardiotoxic group and normal group, with respect to post‑treatment and pretreatment with anthracyclines. Specifically, the serum levels of BNP increased remarkably after treatment with anthracyclines in the cardiotoxic group, compared with the normal group. No publication bias was detected in this meta-analysis. The findings of the present study provide strong evidence that serum BNP levels may be associated with AIC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang YD, Chen SX and Ren LQ: Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity. Oncol Lett 11: 3483-3492, 2016.
APA
Wang, Y., Chen, S., & Ren, L. (2016). Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity. Oncology Letters, 11, 3483-3492. https://doi.org/10.3892/ol.2016.4424
MLA
Wang, Y., Chen, S., Ren, L."Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity". Oncology Letters 11.5 (2016): 3483-3492.
Chicago
Wang, Y., Chen, S., Ren, L."Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity". Oncology Letters 11, no. 5 (2016): 3483-3492. https://doi.org/10.3892/ol.2016.4424
Copy and paste a formatted citation
x
Spandidos Publications style
Wang YD, Chen SX and Ren LQ: Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity. Oncol Lett 11: 3483-3492, 2016.
APA
Wang, Y., Chen, S., & Ren, L. (2016). Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity. Oncology Letters, 11, 3483-3492. https://doi.org/10.3892/ol.2016.4424
MLA
Wang, Y., Chen, S., Ren, L."Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity". Oncology Letters 11.5 (2016): 3483-3492.
Chicago
Wang, Y., Chen, S., Ren, L."Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity". Oncology Letters 11, no. 5 (2016): 3483-3492. https://doi.org/10.3892/ol.2016.4424
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