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FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer

  • Authors:
    • Yingying Liu
    • Tingting Xia
    • Chunhui Jin
    • Dongmei Gu
    • Jie Yu
    • Weiqiang Shi
    • Ke Zhang
    • Liping Zhang
    • Jianxin Ye
    • Ling Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Oncology, Wuxi Hospital of Traditional Chinese Medicine, Wuxi, Jiangsu 214000, P.R. China, Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Gastroenterology, The Second People's Hospital of Changshu, Changshu, Jiangsu 215500, P.R. China, Department of Gastroenterology, Suzhou Municipal Hospital (North), Suzhou, Jiangsu 215008, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3693-3701
    |
    Published online on: April 14, 2016
       https://doi.org/10.3892/ol.2016.4439
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Abstract

The transcription factor forkhead box P3 (FOXP3) is involved in immune cell regulation, and carcinoembryonic antigen‑related cell adhesion molecule 6 (CEACAM6) is an adhesion molecule of the immunoglobulin superfamily. These two genes are associated with cancer progression. In the current study, colon tissue specimens from 78 cases of colon cancer (including 40 of stage I‑II and 38 of stage III‑IV), 30 cases of colonic adenoma and 12 healthy controls were collected from the First Affiliated Hospital of Soochow University between January 2010 and December 2011. The expression of cluster of differentiation (CD) 3, CD4, CD8, CD45RO, CEACAM6 and FOXP3 in colon tissues was examined by immunohistochemical analysis. In addition, a reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) assay, based on SYBR Green I, was used to detect CD3, CD4, CD8, CD45RO, CEACAM6 and FOXP3 mRNA levels in the paraffin block specimens. CD3+, CD8+ and CD45RO+ T cell infiltrations in colonic adenoma were significantly higher than in normal colonic mucosa (P<0.001, P=0.001 and P<0.001, respectively). However, CD3+, CD8+ and CD45RO+ lymphocytes in stage III‑IV colon cancer tissues were lower than in normal control tissues (P=0.015, P=0.002 and P=0.041, respectively); consistently, CD3+, CD4+, CD8+ and CD45RO+ lymphocytes in stage III‑IV tissues were even more markedly lower compared with adenoma (P=0.001, P<0.001, P<0.001 and P<0.001, respectively). Similarly, CD3+, CD8+ and CD45RO+ T cell infiltration was lower in stage I‑II cancer tissues compared with adenoma (P=0.001, P<0.001 and P<0.001). CD3+, CD4+, CD8+ and CD45RO+ T cell infiltrations were also significantly higher in stage I‑II compared with stage III‑IV cancer tissues (P<0.001, P=0.045, P<0.001 and P<0.001, respectively). CEACAM6 was found to gradually increase from normal colon tissue to adenoma and cancer tissue. FOXP3 was expressed more highly in stage I‑II compared with normal tissues (P=0.014), and was even higher in stage III‑IV (P<0.001). These results were verified using RT-qPCR, which yielded almost identical results. In summary, the current study demonstrates that FOXP3, CEACAM6 and T cell infiltration are significantly associated with the occurrence and progression of colon cancer, and that immune reactions vary between different stages of colon cancer development.
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View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Tominaga O, Nita ME, Nagawa H, Fujii S, Tsuruo T and Muto T: Expressions of cell cycle regulators in human colorectal cancer cell lines. Jpn J Cancer Res. 88:855–860. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Rupnarain C, Dlamini Z, Naicker S and Bhoola K: Colon cancer: Genomics and apoptotic events. Biol Chem. 385:449–464. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Karin M: NF-kappaB and cancer: Mechanisms and targets. Mol Carcinog. 45:355–361. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Whisenant J and Bergsland E: Anti-angiogenic strategies in gastrointestinal malignancies. Curr Treat Options Oncol. 6:411–421. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Pancione M, Giordano G, Remo A, Febbraro A, Sabatino L, Manfrin E, Ceccarelli M and Colantuoni V: Immune escape mechanisms in colorectal cancer pathogenesis and liver metastasis. J Immunol Res. 2014:6868792014. View Article : Google Scholar : PubMed/NCBI

8 

Yamauchi M, Lochhead P, Morikawa T, Huttenhower C, Chan AT, Giovannucci E, Fuchs C and Ogino S: Colorectal cancer: A tale of two sides or a continuum? Gut. 61:794–797. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Deschoolmeester V, Baay M, Van Marck E, Weyler J, Vermeulen P, Lardon F and Vermorken JB: Tumor infiltrating lymphocytes: An intriguing player in the survival of colorectal cancer patients. BMC Immunol. 11:192010. View Article : Google Scholar : PubMed/NCBI

10 

Pagès F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, Mlecnik B, Kirilovsky A, Nilsson M, Damotte D, et al: Effector memory T cells, early metastasis and survival in colorectal cancer. N Engl J Med. 353:2654–2666. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Titu LV, Monson JR and Greenman J: The role of CD8(+) T cells in immune responses to colorectal cancer. Cancer Immunol Immunother. 51:235–247. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Chew A, Salama P, Robbshaw A, Klopcic B, Zeps N, Platell C and Lawrance IC: SPARC, FOXP3, CD8 and CD45 correlation with disease recurrence and long-term disease-free survival in colorectal cancer. PLoS One. 6:e220472011. View Article : Google Scholar : PubMed/NCBI

13 

Shevach EM: Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity. 30:636–645. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Xia M, Zhao MQ, Wu K, Lin XY, Liu Y and Qin YJ: Investigations on the clinical significance of FOXP3 protein expression in cervical oesophageal cancer and the number of FOXP3+ tumour-infiltrating lymphocytes. J Int Med Res. 41:1002–1008. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Kobayashi N, Kubota K, Kato S, Watanabe S, Shimamura T, Kirikoshi H, Saito S, Ueda M, Endo I, Inayama Y, et al: FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas. Pancreatology. 10:631–640. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Matsuura K, Yamaguchi Y, Osaki A, Ohara M, Okita R, Emi A, Murakami S and Arihiro K: FOXP3 expression of micrometastasis-positive sentinel nodes in breast cancer patients. Oncol Rep. 22:1181–1187. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Kobayashi N, Hiraoka N, Yamagami W, Ojima H, Kanai Y, Kosuge T, Nakajima A and Hirohashi S: FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res. 13:902–911. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 10:942–949. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Gemei M, Mirabelli P, Di Noto R, Corbo C, Iaccarino A, Zamboli A, Troncone G, Galizia G, Lieto E, Del Vecchio L and Salvatore F: CD66c is a novel marker for colorectal cancer stem cell isolation and its silencing halts tumor growth in vivo. Cancer. 119:729–738. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Duxbury MS, Ito H, Zinner MJ, Ashley SW and Whang EE: CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene. 23:465–473. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Kim KS, Kim JT, Lee SJ, Kang MA, Choe IS, Kang YH, Kim SY, Yeom YI, Lee YH, Kim JH, et al: Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer. Clin Chim Acta. 415:12–19. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Blumenthal RD, Hansen HJ and Goldenberg DM: Inhibition of adhesion, invasion and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen). Cancer Res. 65:8809–8817. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW and Whang EE: A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer Res. 64:3987–3993. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Kobayashi M, Miki Y, Ebina M, Abe K, Mori K, Narumi S, Suzuki T, Sato I, Maemondo M, Endo C, et al: Carcinoembryonic antigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma. Br J Cancer. 107:1745–1753. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Litkouhi B, Litkouhi B, Fleming E, Welch WR, Berkowitz RS, Birrer MJ and Mok SC: Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasms. Gynecol Oncol. 109:234–239. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, Aung PP, Kuraoka K, Nakayama H and Yasui W: Gene expression profile of gastric carcinoma: Identification of genes and tags potentially involved in invasion, metastasis and carcinogenesis by serial analysis of gene expression. Cancer Res. 64:2397–2405. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Jantscheff P, Terracciano L, Lowy A, Glatz-Krieger K, Grunert F, Micheel B, Brümmer J, Laffer U, Metzger U, Herrmann R and Rochlitz C: Expression of CEACAM6 in resectable colorectal cancer: A factor of independent prognostic significance. J Clin Oncol. 21:3638–3646. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Maraqa L, Cummings M, Peter MB, Shaaban AM, Horgan K, Hanby AM and Speirs V: Carcinoembryonic antigen cell adhesion molecule 6 predicts breast cancer recurrence following adjuvant tamoxifen. Clin Cancer Res. 14:405–411. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual (7th). Springer. New York, NY: 2010.

30 

Ma Y, Ma L, Guo Q and Zhang S: Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients. J Exp Clin Cancer Res. 29:852010. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Canna K, McArdle PA, McMillan DC, McNicol AM, Smith GW, McKee RF and McArdle CS: The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Br J Cancer. 92:651–654. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Nosho K, Baba Y, Tanaka N, Shima K, Hayashi M, Meyerhardt JA, Giovannucci E, Dranoff G, Fuchs CS and Ogino S: Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer and prognosis: Cohort study and literature review. J Pathol. 222:350–366. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Pagès F, Kirilovsky A, Mlecnik B, et al: In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol. 27:5944–5951. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Xu W, Liu H, Song J, Fu HX, Qiu L, Zhang BF, Li HZ, Bai J and Zheng JN: The appearance of Tregs in cancer nest is a promising independent risk factor in colon cancer. J Cancer Res Clin Oncol. 139:1845–1852. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Zhuo C, Li Z, Xu Y, et al: Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival. Mol Cancer. 13:1532014. View Article : Google Scholar : PubMed/NCBI

37 

Svensson H, Olofsson V, Lundin S, Yakkala C, Björck S, Börjesson L, Gustavsson B and Quiding-Järbrink M: Accumulation of CCR4+CTLA-4 FOXP3+CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells. PLoS One. 7:e306952012. View Article : Google Scholar : PubMed/NCBI

38 

Deschoolmeester V, Baay M, Lardon F, Pauwels P and Peeters M: Immune cells in colorectal cancer: Prognostic relevance and role of MSI. Cancer Microenviron. 4:377–392. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Viguier M, Lemaître F, Verola O, Cho MS, Gorochov G, Dubertret L, Bachelez H, Kourilsky P and Ferradini L: Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J Immunol. 173:1444–1453. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Stefan Schölzel, Wolfgang Zimmermann, Georg Schwarzkopf, Fritz Grunert, Brigitta Rogaczewski and John Thompson: Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol. 156:595–605. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Witzens-Harig M, Hose D, Jünger S, Pfirschke C, Khandelwal N, Umansky L, Seckinger A, Conrad H, Brackertz B, Rème T, et al: Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6. Blood. 121:4493–4503. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Xia T, Jin C, Gu D, Yu J, Shi W, Zhang K, Zhang L, Ye J, Li L, Li L, et al: FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer. Oncol Lett 11: 3693-3701, 2016.
APA
Liu, Y., Xia, T., Jin, C., Gu, D., Yu, J., Shi, W. ... Li, L. (2016). FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer. Oncology Letters, 11, 3693-3701. https://doi.org/10.3892/ol.2016.4439
MLA
Liu, Y., Xia, T., Jin, C., Gu, D., Yu, J., Shi, W., Zhang, K., Zhang, L., Ye, J., Li, L."FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer". Oncology Letters 11.6 (2016): 3693-3701.
Chicago
Liu, Y., Xia, T., Jin, C., Gu, D., Yu, J., Shi, W., Zhang, K., Zhang, L., Ye, J., Li, L."FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer". Oncology Letters 11, no. 6 (2016): 3693-3701. https://doi.org/10.3892/ol.2016.4439
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Xia T, Jin C, Gu D, Yu J, Shi W, Zhang K, Zhang L, Ye J, Li L, Li L, et al: FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer. Oncol Lett 11: 3693-3701, 2016.
APA
Liu, Y., Xia, T., Jin, C., Gu, D., Yu, J., Shi, W. ... Li, L. (2016). FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer. Oncology Letters, 11, 3693-3701. https://doi.org/10.3892/ol.2016.4439
MLA
Liu, Y., Xia, T., Jin, C., Gu, D., Yu, J., Shi, W., Zhang, K., Zhang, L., Ye, J., Li, L."FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer". Oncology Letters 11.6 (2016): 3693-3701.
Chicago
Liu, Y., Xia, T., Jin, C., Gu, D., Yu, J., Shi, W., Zhang, K., Zhang, L., Ye, J., Li, L."FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer". Oncology Letters 11, no. 6 (2016): 3693-3701. https://doi.org/10.3892/ol.2016.4439
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