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Article

Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing

  • Authors:
    • David Vrána
    • Hana Študentová
    • Marcel Matzenauer
    • Zuzana Vlachová
    • Karel Cwiertka
    • David Gremlica
    • Ondřej Kalita
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc 77900, Czech Republic, Department of Neurosurgery, Faculty of Medicine and Dentistry, Palacky University, Olomouc 77900, Czech Republic
  • Pages: 3777-3781
    |
    Published online on: April 15, 2016
       https://doi.org/10.3892/ol.2016.4440
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Abstract

Renal cell cancer patients with brain metastatic disease generally have poor prognosis. Treatment options include surgery, radiotherapy, targeted therapy or best supportive care with respect to disease burden, patient preference and performance status. In the present case report the radiotherapy technique combining whole brain radiotherapy with hippocampal sparing (hippocampal avoidance whole brain radiotherapy HA‑WBRT) and hypofractionated stereotactic radiotherapy (SRT) of the brain metastases is performed in a patient with metastatic renal cell carcinoma. HA‑WBRT was administered to 30 Gy in 10 fractions with sparing of the hippocampal structures and SRT of 21 Gy in 3 fractions to brain metastases which has preceded the HA‑WBRT. Two single arc volumetric modulated arc radiotherapy (VMAT) plans were prepared using Monaco planning software. The HA‑WBRT treatment plan achieved the following results: D2=33.91 Gy, D98=25.20 Gy, D100=14.18 Gy, D50=31.26 Gy. The homogeneity index was calculated as a deduction of the minimum dose in 2% and 98% of the planning target volume (PTV), divided by the minimum dose in 50% of the PTV. The maximum dose to the hippocampus was 17.50 Gy and mean dose was 11.59 Gy. The following doses to organs at risk (OAR) were achieved: Right opticus Dmax, 31.96 Gy; left opticus Dmax, 30.96 Gy; chiasma D max, 32,76 Gy. The volume of PTV for stereotactic radiotherapy was 3,736 cm3, with coverage D100=20.95 Gy and with only 0.11% of the PTV being irradiated to dose below the prescribed dose. HA‑WBRT with SRT represents a feasible technique for radiotherapy of brain metastatic disease, however this technique is considerably demanding on departmental equipment and staff time/experience.
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1 

Culine S, Bekradda M, Kramar A, Rey A, Escudier B and Droz JP: Prognostic factors for survival in patients with brain metastases from renal cell carcinoma. Cancer. 83:2548–2553. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Escudier B, Porta C, Schmidinger M, Algaba F, Patard JJ, Khoo V, Eisen T and Horwich A: ESMO Guidelines Working Group: Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 25(Suppl 3): iii49–iii56. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tsao MN, Rades D, Wirth A, Lo SS, Danielson BL, Gaspar LE, Sperduto PW, Vogelbaum MA, Radawski JD, Wang JZ, et al: Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline. Pract Radiat Oncol. 2:210–225. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Minniti G, D'Angelillo RM, Scaringi C, Trodella LE, Clarke E, Matteucci P, Osti MF, Ramella S, Enrici RM and Trodella L: Fractionated stereotactic radiosurgery for patients with brain metastases. J Neurooncol. 117:295–301. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Kim YJ, Cho KH, Kim JY, Lim YK, Min HS and Lee SH, Kim HJ, Gwak HS, Yoo H and Lee SH: Single-dose versus fractionated stereotactic radiotherapy for brain metastases. Int J Radiat Oncol Biol Phys. 81:483–489. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG and Byhardt R: Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 37:745–751. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Nieder C, Marienhagen K, Geinitz H and Molls M: Validation of the graded prognostic assessment index for patients with brain metastases. Acta Oncol. 48:457–459. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Villà S, Weber DC, Moretones C, Mañes A, Combescure C, Jové J, Puyalto P, Cuadras P, Bruna J, Verger E, et al: Validation of the new graded prognostic assessment scale for brain metastases: A multicenter prospective study. Radiat Oncol. 6:232011. View Article : Google Scholar : PubMed/NCBI

9 

Nieder C, Andratschke NH, Geinitz H and Grosu AL: Diagnosis-specific graded prognostic assessment score is valid in patients with brain metastases treated in routine clinical practice in two European countries. Med Sci Monit. 18:CR450–CR455. 2012. View Article : Google Scholar : PubMed/NCBI

10 

International Commission on Radiation Units and Measurements: Prescribing, Recording and Reporting Photon Beam Therapy (Report 50). Bethesda: 1993.

11 

International Commission on Radiation Units and Measurements: Prescribing, Recording and Reporting Photon Beam Therapy (Report 62). Bethesda: 1999.

12 

International Commission on Radiation Units and Measurements: Prescribing, Recording and Reporting Intensity-Modulated Photon-Beam Therapy (IMRT) (ICRU Report 83). Washington: 2010.

13 

Gondi V, Pugh SL, Tome WA, Caine C, Corn B, Kanner A, Rowley H, Kundapur V, DeNittis A, Greenspoon JN, et al: Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): A phase II multi-institutional trial. J Clin Oncol. 32:3810–3816. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Rades D, Bohlen G, Pluemer A, Veninga T, Hanssens P, Dunst J and Schild SE: Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients. Cancer. 109:2515–2521. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Karlovits BJ, Quigley MR, Karlovits SM, Miller L, Johnson M, Gayou O and Fuhrer R: Stereotactic radiosurgery boost to the resection bed for oligometastatic brain disease: Challenging the tradition of adjuvant whole-brain radiotherapy. Neurosurg Focus. 27:E72009. View Article : Google Scholar : PubMed/NCBI

16 

Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, et al: Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952–26001 study. J Clin Oncol. 29:134–141. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Iwadate Y, Namba H and Yamaura A: Whole-brain radiation therapy is not beneficial as an adjuvant therapy for brain metastases compared with localized irradiation. Anticancer Res. 22:325–330. 2002.PubMed/NCBI

18 

Mintz A, Perry J, Spithoff K, Chambers A and Laperriere N: Management of single brain metastasis: A practice guideline. Curr Oncol. 14:131–143. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, et al: Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial. JAMA. 295:2483–2491. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Tsao MN, Lloyd NS and Wong RK: Supportive Care Guidelines Group of Cancer Care Ontario's Program in Evidence-based Care: Clinical practice guideline on the optimal radiotherapeutic management of brain metastases. BMC Cancer. 5:342005. View Article : Google Scholar : PubMed/NCBI

21 

Khuntia D, Brown P, Li J and Mehta MP: Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol. 24:1295–1304. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Soon YY, Tham IW, Lim KH, Koh WY and Lu JJ: Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases. Cochrane Database Syst Rev. 3:CD0094542014.PubMed/NCBI

23 

Kocher M, Maarouf M, Bendel M, Voges J, Müller RP and Sturm V: Linac radiosurgery versus whole brain radiotherapy for brain metastases. A survival comparison based on the RTOG recursive partitioning analysis. Strahlenther Onkol. 180:263–267. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Rades D and Schild SE: Do patients with a limited number of brain metastases need whole-brain radiotherapy in addition to radiosurgery? Strahlenther Onkol. 188:702–706. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Golden DW, Lamborn KR, McDermott MW, Kunwar S, Wara WM, Nakamura JL and Sneed PK: Prognostic factors and grading systems for overall survival in patients treated with radiosurgery for brain metastases: Variation by primary site. J Neurosurg. 109(Suppl): S77–S86. 2008.

26 

Kocher M, Wittig A, Piroth MD, Treuer H, Seegenschmiedt H, Ruge M, Grosu AL and Guckenberger M: Stereotactic radiosurgery for treatment of brain metastases. A report of the DEGRO working group on stereotactic radiotherapy. Strahlenther Onkol. 190:521–532. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Bates JE, Youn P, Peterson CR III, Usuki KY, Walter KA, Okunieff P and Milano MT: Radiotherapy for brain metastases from renal cell carcinoma in the targeted therapy Era: The university of Rochester experience. Am J Clin Oncol. 2015 Feb 26;(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

28 

Fokas E, Henzel M, Hamm K, Surber G, Kleinert G and Engenhart-Cabillic R: Radiotherapy for brain metastases from renal cell cancer: Should whole-brain radiotherapy be added to stereotactic radiosurgery? Analysis of 88 patients. Strahlenther Onkol. 186:210–217. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Rades D, Kueter JD, Hornung D, Veninga T, Hanssens P, Schild SE and Dunst J: Comparison of stereotactic radiosurgery (SRS) alone and whole brain radiotherapy (WBRT) plus a stereotactic boost (WBRT+SRS) for one to three brain metastases. Strahlenther Onkol. 184:655–662. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH and Meyers CA: Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial. Lancet Oncol. 10:1037–1044. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Mizumatsu S, Monje ML, Morhardt DR, Rola R, Palmer TD and Fike JR: Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 63:4021–4027. 2003.PubMed/NCBI

32 

Collier TJ, Quirk GJ and Routtenberg A: Separable roles of hippocampal granule cells in forgetting and pyramidal cells in remembering spatial information. Brain Res. 409:316–328. 1987. View Article : Google Scholar : PubMed/NCBI

33 

Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, VandenBerg SR and Fike JR: Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res. 162:39–47. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Rades D, Kueter JD, Pluemer A, Veninga T and Schild SE: A matched-pair analysis comparing whole-brain radiotherapy plus stereotactic radiosurgery versus surgery plus whole-brain radiotherapy and a boost to the metastatic site for one or two brain metastases. Int J Radiat Oncol Biol Phys. 73:1077–1081. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Suh JH: Hippocampal-avoidance whole-brain radiation therapy: A new standard for patients with brain metastases? J Clin Oncol. 32:3789–3791. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Sahgal A, Larson D and Knisely J: Stereotactic radiosurgery alone for brain metastases. Lancet Oncol. 16:249–250. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Langley RE, Stephens RJ, Nankivell M, Pugh C, Moore B, Navani N, Wilson P, Faivre-Finn C, Barton R, Parmar MK and Mulvenna PM: QUARTZ Investigators: Interim data from the Medical Research Council QUARTZ Trial: does whole brain radiotherapy affect the survival and quality of life of patients with brain metastases from non-small cell lung cancer? Clin Oncol (R Coll Radiol). 25:e23–e30. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Prokic V, Wiedenmann N, Fels F, Schmucker M, Nieder C and Grosu AL: Whole brain irradiation with hippocampal sparing and dose escalation on multiple brain metastases: A planning study on treatment concepts. Int J Radiat Oncol Biol Phys. 85:264–270. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Ghia A, Tomé WA, Thomas S, Cannon G, Khuntia D, Kuo JS and Mehta MP: Distribution of brain metastases in relation to the hippocampus: Implications for neurocognitive functional preservation. Int J Radiat Oncol Biol Phys. 68:971–977. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Antonadou D, Coliarakis N, Paraskevaidis M, Athanasiou H, Sarris G, Synodinou M, Skarlatos I, Sagriotis A, Georgakopoulos G, Beroukas C, et al: Whole brain radiotherapy alone or in combination with temazolamide for brain metastases. A phase III study. Int J Radiat Oncol Biol Phys. 54:932002. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Vrána D, Študentová H, Matzenauer M, Vlachová Z, Cwiertka K, Gremlica D and Kalita O: Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing. Oncol Lett 11: 3777-3781, 2016.
APA
Vrána, D., Študentová, H., Matzenauer, M., Vlachová, Z., Cwiertka, K., Gremlica, D., & Kalita, O. (2016). Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing. Oncology Letters, 11, 3777-3781. https://doi.org/10.3892/ol.2016.4440
MLA
Vrána, D., Študentová, H., Matzenauer, M., Vlachová, Z., Cwiertka, K., Gremlica, D., Kalita, O."Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing". Oncology Letters 11.6 (2016): 3777-3781.
Chicago
Vrána, D., Študentová, H., Matzenauer, M., Vlachová, Z., Cwiertka, K., Gremlica, D., Kalita, O."Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing". Oncology Letters 11, no. 6 (2016): 3777-3781. https://doi.org/10.3892/ol.2016.4440
Copy and paste a formatted citation
x
Spandidos Publications style
Vrána D, Študentová H, Matzenauer M, Vlachová Z, Cwiertka K, Gremlica D and Kalita O: Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing. Oncol Lett 11: 3777-3781, 2016.
APA
Vrána, D., Študentová, H., Matzenauer, M., Vlachová, Z., Cwiertka, K., Gremlica, D., & Kalita, O. (2016). Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing. Oncology Letters, 11, 3777-3781. https://doi.org/10.3892/ol.2016.4440
MLA
Vrána, D., Študentová, H., Matzenauer, M., Vlachová, Z., Cwiertka, K., Gremlica, D., Kalita, O."Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing". Oncology Letters 11.6 (2016): 3777-3781.
Chicago
Vrána, D., Študentová, H., Matzenauer, M., Vlachová, Z., Cwiertka, K., Gremlica, D., Kalita, O."Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing". Oncology Letters 11, no. 6 (2016): 3777-3781. https://doi.org/10.3892/ol.2016.4440
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