Bellini's duct carcinoma: A report of two cases and a review of the literature

Li,Yifan; Jin,Lu; Liu,Jiaju; Chen,Duqun; Su,Zhengming; Zhou,Liqun; Shi,Bentao; Lai,Yongqing

doi:10.3892/ol.2016.4454

June-2016 Volume 11 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

June-2016 Volume 11 Issue 6

Full Size Image

Article

Bellini's duct carcinoma: A report of two cases and a review of the literature

Authors:
- Yifan Li
- Lu Jin
- Jiaju Liu
- Duqun Chen
- Zhengming Su
- Liqun Zhou
- Bentao Shi
- Yongqing Lai
View Affiliations / Copyright

Affiliations: Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing 100034, P.R. China
Pages: 3839-3841
|
Published online on: April 18, 2016

https://doi.org/10.3892/ol.2016.4454
Expand metrics +

Abstract

Bellini's duct carcinoma (BDC) is a rare and aggressive variant of renal cell carcinoma that possesses an extremely poor prognosis. The greater the grade or stage of disease, the poorer the prognosis tends to be. This study presents two cases of BDC; one case of low grade BDC and one case of high grade BDC in a 47‑year‑old male and 74‑year‑old female, respectively. The 47-year-old male patient presented with painless gross hematuria, which had lasted for 3 weeks and subsequently underwent purely laparoscopic nephroureterectomy. After 4‑years of follow‑up, the patient remained disease‑free. By contrast, a right renal tumor was identified in the 74‑year‑old female patient during a routine examination. Radical right nephrectomy and lymph node dissection were performed, however, 10 months after surgery the patient succumbed due to wide‑spread metastasis. The two cases reported in the present study not only represent excellent examples of the disease spectrum, but also act as a reminder of the possibility of detecting BDC in an early stage of disease. Therefore, the epidemiology of BDC has been discussed, and the aggressive growth pattern of BDC has been presented in terms of signs, symptoms and imaging examinations, including ultrasonography, computed tomography (CT), angiography and single photon emission CT, in the early stage of disease.

View Figures

View References

1	Cohen HT and McGovern FJ: Renal-cell carcinoma. N Engl J Med. 353:2477–2490. 2005. View Article : Google Scholar : PubMed/NCBI
2	Miyake H, Haraguchi T, Takenaka A and Fujisawa M: Metastatic collecting duct carcinoma of the kidney responded to sunitinib. Int J Clin Oncol. 16:153–155. 2011. View Article : Google Scholar : PubMed/NCBI
3	Otani M, Shimizu T, Serizawa H, Ebihara Y and Nagashima Y: Low-grade renal cell carcinoma arising from the lower nephron: A case report with immunohistochemical, histochemical and ultrastructural studies. Pathol Int. 51:954–960. 2001. View Article : Google Scholar : PubMed/NCBI
4	Farah R, Ben-Izhak O, Munichor M and Cohen H: Low-grade renal collecting duct carcinoma. A case report with histochemical, immunohistochemical, and ultrastructural study. Ann Diagn Pathol. 9:46–48. 2005. View Article : Google Scholar : PubMed/NCBI
5	Vázquez-Lavista LG, Uribe-Uribe N and Gabilondo-Navarro F: Collecting duct renal cell carcinoma: Two different clinical stages, two different clinical outcomes. Urol Int. 81:116–118. 2008. View Article : Google Scholar : PubMed/NCBI
6	Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: Kidney. AJCC Cancer Staging Manual (7th). Springer Verlag. (New York, NY). 479–489. 2010.
7	Tokuda N, Naito S, Matsuzaki O, Nagashima Y, Ozono S and Igarashi T: Japanese Society of Renal Cancer: Collecting duct (Bellini duct) renal cell carcinoma: A nationwide survey in Japan. J Urol. 176:40–43. 2006. View Article : Google Scholar : PubMed/NCBI
8	Antonelli A, Portesi E, Cozzoli A, Zanotelli T, Tardanico R, Balzarini P, Grigolato PG and Cosciani Cunico S: The collecting duct carcinoma of the kidney: A cytogenetical study. Eur Urol. 43:680–685. 2003. View Article : Google Scholar : PubMed/NCBI
9	Amin MB, Amin MB, Tamboli P, Javidan J, Stricker H, de-Peralta Venturina M, Deshpande A and Menon M: Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: An experience of 405 cases. Am J Surg Pathol. 26:281–291. 2002. View Article : Google Scholar : PubMed/NCBI
10	Auguet T, Molina JC, Lorenzo A, Vila J, Sirvent JJ and Richart C: Synchronus renal cell carcinoma and Bellini duct carcinoma: A case report on a rare coincidence. World J Urol. 18:449–451. 2000. View Article : Google Scholar : PubMed/NCBI
11	Motzer RJ, Bander NH and Nanus DM: Renal-cell carcinoma. N Engl J Med. 335:865–875. 1996. View Article : Google Scholar : PubMed/NCBI
12	Hennessey DB, Thomas AZ and Lynch TH: Mixed collecting duct and renal cell carcinoma presenting with spinal cord compression. BMJ Case Rep. 19:bcr20130089872013.
13	Ockrim J, Tsiriopoulos I, Rees H, Mendoza N and Christmas TJ: Collecting duct carcinoma of the renal medulla presenting with paraplegia. Int Urol Nephrol. 37:465–466. 2005. View Article : Google Scholar : PubMed/NCBI
14	Schubert PT, Louw M, Scubert C, Eedes C and Theron J: A uncommon cause of haemoptysis: Metastatic collecting duct renal carcinoma. Diagn Cytopathol. 39:938–940. 2011. View Article : Google Scholar : PubMed/NCBI
15	Pickhardt PJ, Siegel CL and McLarney JK: Collecting duct carcinoma of the kidney: Are imaging findings suggestive of the diagnosis? AJR Am J Roentgenol. 176:627–633. 2001. View Article : Google Scholar : PubMed/NCBI
16	Wang L, Peng L, Hou T and Shi Y: Renal collecting duct carcinoma: Report of a case with unusual imaging findings regarding renal function. J Cancer Res Ther. 9:331–333. 2013. View Article : Google Scholar : PubMed/NCBI
17	Zhang J, Lefkowitz RA, Ishill NM, Wang L, Moskowitz CS, Russo P, Eisenberg H and Hricak H: Solid renal cortical tumors: Differentiation with CT. Radiology. 244:494–504. 2007. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Bellini's duct carcinoma: A report of two cases and a review of the literature

This article is mentioned in:

Abstract

Related Articles