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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June-2016 Volume 11 Issue 6

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Case Report

Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report

  • Authors:
    • Atsuto Katano
    • Hideomi Yamashita
    • Kae Okuma
    • Keiichi Nakagawa
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, University of Tokyo Hospital, Tokyo 113‑8655, Japan
  • Pages: 3901-3903
    |
    Published online on: April 19, 2016
       https://doi.org/10.3892/ol.2016.4462
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Abstract

Esophageal cancer is a highly lethal malignancy of the upper gastrointestinal tract. The recurrence of the cancer indicates a poor prognosis, and even salvage therapy using multi‑agent combination chemotherapy, which is considered more effective than single‑agent chemotherapy, is not able to achieve a sufficient response. The present study reports the case of a 74‑year‑old male who presented to a local hospital with dysphagia in February 2006. Upon radiographic and pathological examination, the patient was diagnosed with squamous cell carcinoma of esophagus that was clinically staged as T3N1M1. The patient was referred to the University of Tokyo Hospital (Tokyo, Japan) for concurrent chemoradiotherapy using a radiation dose of 50.4 Gy in 28 fractions, and subsequently achieved a complete response (CR). At 8 years after the initial diagnosis and subsequent treatment, the patient presented with abdominal swollen lymph nodes that were 38 mm and 22 mm in diameter. Recurrent metastasis was diagnosed. A single‑agent regimen was selected due to the patient's poor performance status. This consisted of 2 cycles of oral S‑1 administration twice a day for 2 consecutive weeks, followed by 2 weeks of rest (80 mg/day for 14 days/cycle). A CR was achieved following the use of S‑1 administration as salvage therapy. The patient exhibited no signs of recurrence subsequent to 9 months of follow‑up. Overall, the present study reports that S‑1 administration shows marked effectiveness in the treatment of huge recurrent lesions. S‑1 is considered as a good treatment option in patients with poor a performance status who require salvage therapy.
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1 

Pennathur A, Gibson MK, Jobe BA and Luketich JD: Oesophageal carcinoma. Lancet. 381:400–412. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Zhang Y: Epidemiology of esophageal cancer. World J Gastroenterol. 19:5598–5606. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Enzinger PC and Mayer RJ: Esophageal Cancer. N Engl J Med. 349:2241–2252. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Quint LE, Hepburn LM, Francis IR, Whyte RI and Orringer MB: Incidence and distribution of distant metastases from newly diagnosed esophageal carcinoma. Cancer. 76:1120–1125. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Ilson DH: Esophageal cancer chemotherapy: Recent advances. Gastrointest Cancer Res. 2:85–92. 2008.PubMed/NCBI

6 

Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG and Morrow M: Esophagus. American Joint Committee on Cancer (AJCC) Cancer Staging Manual (6th). Springer. (New York, NY). 90–95. 2002.

7 

Trotti A, Colevas AD, Setser A, Rusch V, Jaques D, Budach V, Langer C, Murphy B, Cumberlin R, Coleman CN and Rubin P: CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 13:176–181. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Iizuka T, Kakegawa T, Ide H, Ando N, Watanabe H, Tanaka O, Takagi I, Isono K, Ishida K, Arimori M, et al: Phase II evaluation of cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of the esophagus: A Japanese esophageal oncology group trial. Jpn J Clin Oncol. 22:172–176. 1992.PubMed/NCBI

9 

The National Comprehensive Cancer Network (NCCN) Guidelines Version 1.2014: Esophageal and Esophagogastric Junction Cancers. http://www.nccn.org/professionals/physician_gls/pdf/esophageal.pdfAccessed. March 01–2015

10 

Cunningham D, Okines AF and Ashley S: Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 362:858–859. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Shirasaka T, Shimamato Y, Ohshimo H, Yamaguchi M, Kato T, Yonekura K and Fukushima M: Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs. 7:548–557. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Akutsu Y, Kono T, Uesato M, Hoshino I, Narushima K, Hanaoka T, Tochigi T, Semba Y, Qin W and Matsubara H: S-1 monotherapy as second- or third-line chemotherapy for unresectable and recurrent esophageal squamous cell carcinoma. Oncology. 84:305–310. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, Miyashita K, Nishizaki T, Kobayashi O, Takiyama W, et al: S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): A phase III trial. Lancet Oncol. 9:215–221. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Hiraki M, Yunotani S, Noguchi R, Shinozaki Y, Tani H, Sakai M, Ishimitsu T and Tabuchi M: Recurrence of esophageal cancer treated by combination TS-1/CDDP therapy. Gan To Kagaku Ryoho. 32:219–221. 2005.(In Japanese). PubMed/NCBI

15 

Kanamori N, Fujii M, Takahashi T, Wakabayashi K, Kochi M, Sou K and Takayama T: A patient with esophageal cancer recurrence responding to S-1 combined with cisplatin (CDDP). Gan To Kagaku Ryoho. 34:1459–1461. 2007.(In Japanese). PubMed/NCBI

16 

Kubota K, Mafune K, Yamada K, Yamashita H, Kuroda J, Aikou S and Kaminishi M: Complete regression of advanced esophageal cancer with abdominal bulky lymph node metastasis treated by concurrent chemoradiotherapy using docetaxel, cisplatin and 5-fluorouracil. Esophagus. 6:183–187. 2009. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Katano A, Yamashita H, Okuma K and Nakagawa K: Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report. Oncol Lett 11: 3901-3903, 2016.
APA
Katano, A., Yamashita, H., Okuma, K., & Nakagawa, K. (2016). Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report. Oncology Letters, 11, 3901-3903. https://doi.org/10.3892/ol.2016.4462
MLA
Katano, A., Yamashita, H., Okuma, K., Nakagawa, K."Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report". Oncology Letters 11.6 (2016): 3901-3903.
Chicago
Katano, A., Yamashita, H., Okuma, K., Nakagawa, K."Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report". Oncology Letters 11, no. 6 (2016): 3901-3903. https://doi.org/10.3892/ol.2016.4462
Copy and paste a formatted citation
x
Spandidos Publications style
Katano A, Yamashita H, Okuma K and Nakagawa K: Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report. Oncol Lett 11: 3901-3903, 2016.
APA
Katano, A., Yamashita, H., Okuma, K., & Nakagawa, K. (2016). Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report. Oncology Letters, 11, 3901-3903. https://doi.org/10.3892/ol.2016.4462
MLA
Katano, A., Yamashita, H., Okuma, K., Nakagawa, K."Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report". Oncology Letters 11.6 (2016): 3901-3903.
Chicago
Katano, A., Yamashita, H., Okuma, K., Nakagawa, K."Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report". Oncology Letters 11, no. 6 (2016): 3901-3903. https://doi.org/10.3892/ol.2016.4462
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