Primary thyroid leiomyosarcoma: A case report and literature review

Zou,Zhen‑Yu; Ning,Ning; Li,Song‑Yan; Li,Jie; Du,Xiao‑Hui; Li,Rong

doi:10.3892/ol.2016.4496

Primary thyroid leiomyosarcoma: A case report and literature review

Authors:
- Zhen‑Yu Zou
- Ning Ning
- Song‑Yan Li
- Jie Li
- Xiao‑Hui Du
- Rong Li
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Affiliations: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China, Department of Gastrointestinal Surgery, Peking University International Hospital, Beijing 102206, P.R. China, Department of Pathology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China
Published online on: April 26, 2016 https://doi.org/10.3892/ol.2016.4496
Pages: 3982-3986
Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary thyroid leiomyosarcoma (LMS) is an extremely rare soft tissue cancer; only 22 cases have been reported in the literature to date. In the current study, the case of an 83‑year‑old male patient who presented with a neck mass that had grown rapidly over the previous 3 months is reported. The patient underwent thyroid lobectomy twice and two cycles of immunotherapy for the treatment of primary thyroid LMS; however, he succumbed to the disease 5 months after the second surgery. An accurate diagnosis of primary thyroid LMS is difficult, as the disease is often misdiagnosed as anaplastic carcinoma, and requires the combined assessment of clinical, imaging and pathological data. Diagnosis of the current patient with primary thyroid LMS and a comprehensive review of the relevant literature are presented herein.

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1	Adachi M, Wellmann KF and Garcia R: Metastatic leiomyosarcoma in brain and heart. J Pathol. 98:294–296. 1969. View Article : Google Scholar : PubMed/NCBI
2	Kawahara E, Nakanishi I, Terahata S and Ikegaki S: Leiomyosarcoma of the thyroid gland. A case report with a comparative study of five cases of anaplastic carcinoma. Cancer. 62:2558–2563. 1988. View Article : Google Scholar : PubMed/NCBI
3	Kaur A and Jayaram G: Thyroid tumors: Cytomorphology of medullary, clinically anaplastic and miscellaneous thyroid neoplasms. Diagn Cytopathol. 6:383–389. 1990. View Article : Google Scholar : PubMed/NCBI
4	Chetty R, Clark SP and Dowling JP: Leiomyosarcoma of the thyroid: Immunohistochemical and ultrastructural study. Pathology. 25:203–205. 1993. View Article : Google Scholar : PubMed/NCBI
5	Iida Y, Katoh R, Yoshioka M, Oyama T and Kawaoi A: Primary leiomyosarcoma of the thyroid gland. Acta Pathol Jpn. 43:71–75. 1993.PubMed/NCBI
6	Ozaki O, Sugino K, Mimura T, Ito K, Tamai S and Hosoda Y: Primary leiomyosarcoma of the thyroid gland. Surg Today. 27:177–180. 1997. View Article : Google Scholar : PubMed/NCBI
7	Thompson LD, Wenig BM, Adair CF, Shmookler BM and Heffess CS: Primary smooth muscle tumors of the thyroid gland. Cancer. 79:579–587. 1997. View Article : Google Scholar : PubMed/NCBI
8	Tsugawa K, Koyanagi N, Nakanishi K, Wada H, Tanoue K, Hashizume M and Sugimachi K: Leiomyosarcoma of the thyroid gland with rapid growth and tracheal obstruction: A partial thyroidectomy and tracheostomy using an ultrasonically activated scalpel can be safely performed with less bleeding. Eur J Med Res. 4:483–487. 1999.PubMed/NCBI
9	Tulbah A, Al-Dayel F, Fawaz I and Rosai J: Epstein-Barr virus-associated leiomyosarcoma of the thyroid in a child with congenital immunodeficiency: A case report. Am J Surg Pathol. 23:473–476. 1999. View Article : Google Scholar : PubMed/NCBI
10	Takayama F, Takashima S, Matsuba H, Kobayashi S, Ito N and Sone S: MR imaging of primary leiomyosarcoma of the thyroid gland. Eur J Radiol. 37:36–41. 2001. View Article : Google Scholar : PubMed/NCBI
11	Day AS, Lou PJ, Lin WC and Chou CC: Over-expression of c-kit in a primary leiomyosarcoma of the thyroid gland. Eur Arch Otorhinolaryngol. 264:705–708. 2007. View Article : Google Scholar : PubMed/NCBI
12	Just PA, Guillevin R, Capron F, Le Charpentier M, Le Naour G, Menegaux F, Leenhardt L, Simon JM and Hoang C: An unusual clinical presentation of a rare tumor of the thyroid gland: Report on one case of leiomyosarcoma and review of literature. Ann Diagn Pathol. 12:50–56. 2008. View Article : Google Scholar : PubMed/NCBI
13	Mansouri H, Gaye M, Errihani H, Kettani F and Gueddari BE: Leiomyosarcoma of the thyroid gland. Acta Otolaryngol. 128:335–336. 2008. View Article : Google Scholar : PubMed/NCBI
14	Wang TS, Ocal IT, Oxley K and Sosa JA: Primary leiomyosarcoma of the thyroid gland. Thyroid. 18:425–428. 2008. View Article : Google Scholar : PubMed/NCBI
15	Bertelli AA, Massarollo LC, Volpi EM, Ueda RY and Barreto E: Thyroid gland primary leiomyosarcoma. Arq Bras Endocrinol Metabol. 54:326–330. 2010.(In Portuguese). View Article : Google Scholar : PubMed/NCBI
16	Amal B, El Fatemi H, Souaf I, Moumna K and Affaf A: A rare primary tumor of the thyroid gland: Report a new case of leiomyosarcoma and literature review. Diagn Pathol. 8:362013. View Article : Google Scholar : PubMed/NCBI
17	Ege B and Leventoğlu S: Primary leiomyosarcoma of the thyroid. J Korean Surg Soc. 85:43–46. 2013. View Article : Google Scholar : PubMed/NCBI
18	Mouaqit O, Belkacem Z, Ifrine L, Mohsine R and Belkouchi A: A rare tumor of the thyroid gland: Report on one case of leiomyosarcoma and review of literature. Updates Surg. 66:165–167. 2014. View Article : Google Scholar : PubMed/NCBI
19	Tanboon J and Keskool P: Leiomyosarcoma: A rare tumor of the thyroid. Endocr Pathol. 24:136–143. 2013. View Article : Google Scholar : PubMed/NCBI
20	Bathan AJ, Constantinidou A, Pollack SM and Jones RL: Diagnosis, prognosis, and management of leiomyosarcoma: recognition of anatomic variants. Curr Opin Oncol. 25:384–389. 2013. View Article : Google Scholar : PubMed/NCBI
21	Agrawal M, Uppin SG, Challa S and Prayaga AK: Carcinosarcoma thyroid: An unusual morphology with a review of the literature. South Asian J Cancer. 2:2262013. View Article : Google Scholar : PubMed/NCBI
22	Naqiyah I, Zulkarnaen AN, Rohaizak M and Das S: Carcinosarcoma of the thyroid: A case report. Hippokratia. 14:141–142. 2010.PubMed/NCBI
23	Edris B, Weiskopf K, Volkmer AK, Volkmer JP, Willingham SB, Contreras-Trujillo H, Liu J, Majeti R, West RB, Fletcher JA, et al: Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc Natl Acad Sci USA. 109:6656–6661. 2012. View Article : Google Scholar : PubMed/NCBI