Association between FBP1 and hypoxia‑related gene expression in clear cell renal cell carcinoma

  • Authors:
    • Xiang‑Hui Ning
    • Teng Li
    • Yan‑Qing Gong
    • Qun He
    • Qi Shen
    • Shuang‑He Peng
    • Jiang‑Yi Wang
    • Jin‑Chao Chen
    • Ying‑Lu Guo
    • Kan Gong
  • View Affiliations

  • Published online on: April 27, 2016     https://doi.org/10.3892/ol.2016.4504
  • Pages: 4095-4098
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Abstract

Fructose-1,6-bisphosphatase 1 (FBP1) is a rate-limiting enzyme in gluconeogenesis. Recently, the catalytic activity‑independent function of FBP1, hypoxia‑induced factor (HIF) repression in the nucleus, was identified. The aim of the present study was to investigate the association between FBP1 and hypoxia‑related gene expression in clear cell renal cell carcinoma (ccRCC). The protein expression levels of FBP1, HIF‑1α, HIF‑2α, erythropoietin (EPO) and carbonic anhydrase IX (CA9) were assessed by immunohistochemical staining of ccRCC paraffin blocks from 123 patients using the tissue microarray technique. The expression level of FBP1 was then correlated with various clinicopathological factors, and the protein expression levels of HIF‑1α, HIF‑2α, EPO and CA9. Clinicopathological factors, including age, gender, T stage and Fuhrman grade, were not significantly different between patients with low and high FBP1 expression in ccRCC (P>0.05). FBP1 protein expression level was significantly correlated with the expression levels of HIF‑1α (P=0.005) and EPO (P=0.010), but not significantly correlated with the expression levels of HIF‑2α (P=0.123) and CA9 (P=0.513) in ccRCC tissues. The current findings confirm the association between FBP1 and hypoxia‑related gene expression, and may facilitate understanding of the mechanisms of ccRCC tumorigenesis.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ning XH, Li T, Gong YQ, He Q, Shen Q, Peng SH, Wang JY, Chen JC, Guo YL, Gong K, Gong K, et al: Association between FBP1 and hypoxia‑related gene expression in clear cell renal cell carcinoma. Oncol Lett 11: 4095-4098, 2016
APA
Ning, X., Li, T., Gong, Y., He, Q., Shen, Q., Peng, S. ... Gong, K. (2016). Association between FBP1 and hypoxia‑related gene expression in clear cell renal cell carcinoma. Oncology Letters, 11, 4095-4098. https://doi.org/10.3892/ol.2016.4504
MLA
Ning, X., Li, T., Gong, Y., He, Q., Shen, Q., Peng, S., Wang, J., Chen, J., Guo, Y., Gong, K."Association between FBP1 and hypoxia‑related gene expression in clear cell renal cell carcinoma". Oncology Letters 11.6 (2016): 4095-4098.
Chicago
Ning, X., Li, T., Gong, Y., He, Q., Shen, Q., Peng, S., Wang, J., Chen, J., Guo, Y., Gong, K."Association between FBP1 and hypoxia‑related gene expression in clear cell renal cell carcinoma". Oncology Letters 11, no. 6 (2016): 4095-4098. https://doi.org/10.3892/ol.2016.4504